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Home › Research › Topics › mice

mice

1,163 studies tagged mice, dated 1986-01-01 to 2026-09-25. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. What Do Sugar, Gila Monsters, and the Therapeutic Dance Have in Common With GLP-1RA, Stroke, and Dementia? 2026-09-25
  2. Myo-inositol as a spectroscopic marker of neuroinflammation in frontotemporal lobar degeneration 2026-09-20
  3. Laromestrocel preserves brain volume and cognitive function in Alzheimers disease by inhibiting neuroinflammation 2026-09-17

Studies

1,163 studies carry this tag.

Date range

1986 to 2026

Top journals

  • The Journal of biological chemistry 109
  • The Journal of neuroscience : the official journal of the Society for Neuroscience 42
  • Proceedings of the National Academy of Sciences of the United States of America 39
  • Neuron 28
  • Nature 23

365 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Human TBK1: A Gatekeeper of Neuroinflammation

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Trends in molecular medicine 2016-06-01 Inflammation and the immune system

    The importance of TANK binding kinase-1 (TBK1), a multimeric kinase that modulates inflammation and autophagy, in human health has been highlighted for the first time by the recent discoveries of mutations in TBK1 that underlie amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), normal tension glaucoma (NTG) or childhood herpes simplex encephalitis (HSE).

  2. Orexin-A is Associated with Increases in Cerebrospinal Fluid Phosphorylated-Tau in Cognitively Normal Elderly Subjects

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Sleep 2016-06-01 Tau biomarkers

    Study objectives To evaluate the role of orexin-A with respect to cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers, and explore its relationship to cognition and sleep characteristics in a group of cognitively normal elderly individuals.

  3. Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Neurobiology of aging 2016-05-17 Drug development

    Currently, several immunotherapies and BACE (Beta Site APP Cleaving Enzyme) inhibitor approaches are being tested in the clinic for the treatment of Alzheimer's disease.

  4. BIN1 regulates BACE1 intracellular trafficking and amyloid-β production

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Human molecular genetics 2016-05-14 Genetics

    BIN1 is a genetic risk factor of late-onset Alzheimer disease (AD), which was identified in multiple genome-wide association studies.

  5. Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neurotrauma 2016-05-09 TREM2 and immune genetics

    Traumatic brain injury (TBI) affects 1.7 million persons annually in the United States (Centers for Disease Control and Prevention).

  6. Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Scientific reports 2016-04-22 Disease mechanisms

    The incidence of dementia is higher in diabetic patients, but no effective treatment has been developed.

  7. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neuron 2016-04-21 Lewy body dementia

    Hexanucleotide expansions in C9ORF72 are the most frequent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia.

  8. Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. The EMBO journal 2016-04-21 Lewy body dementia

    An intronic expansion of GGGGCC repeats within the C9ORF72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD).

  9. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Cell 2016-04-21 Lewy body dementia

    Microglia maintain homeostasis in the brain, but whether aberrant microglial activation can cause neurodegeneration remains controversial.

  10. Green-Fluorescent Protein(+) Astrocytes Attach to Beta-Amyloid Plaques in an Alzheimer Mouse Model and Are Sensitive for Clasmatodendrosis

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Frontiers in aging neuroscience 2016-04-08 Biomarkers

    Alzheimer's disease (AD) is pathologically characterized by beta-amyloid (Aβ) plaques and Tau pathology.

  11. Dopa-responsive akinesia: Homozygous GCH1 mutation (P5.150)

    ✓ Peer-reviewed alzhub usefulness score 31 out of 100. Neurology 2016-04-05 Health systems and care delivery

    This individual had childhood-onset progressive motor impairment.

  12. Complement and microglia mediate early synapse loss in Alzheimer mouse models

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Science (New York, N.Y.) 2016-03-31 Brain tissue and pathology

    Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline.

  13. C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Nature neuroscience 2016-03-21 Brain tissue and pathology

    Neuronal inclusions of poly(GA), a protein unconventionally translated from G4C2 repeat expansions in C9ORF72, are abundant in patients with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) caused by this mutation.

  14. Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Acta neuropathologica communications 2016-03-16 TREM2 and immune genetics

    Alzheimer's disease (AD) is associated with the accumulation of β-amyloid (Aβ) as senile plaques in the brain, thus leading to neurodegeneration and cognitive impairment.

  15. Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neuropharmacology 2016-03-16 Getting a diagnosis

    The kynurenine pathway (KP) of tryptophan metabolism has emerged in recent years as a key regulator of the production of both neuroprotective (e.g. kynurenic and picolinic acid, and the essential cofactor NAD+) and neurotoxic metabolites (e.g. quinolinic acid, 3-hydroxykynurenine).

  16. C9orf72 is required for proper macrophage and microglial function in mice

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Science (New York, N.Y.) 2016-03-01 Lewy body dementia

    Expansions of a hexanucleotide repeat (GGGGCC) in the noncoding region of the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.

  17. CCR5 deficiency accelerates lipopolysaccharide-induced astrogliosis, amyloid-beta deposit and impaired memory function

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Oncotarget 2016-03-01 Biomarkers

    Chemokine receptors are implicated in inflammation and immune responses.

  18. Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. American journal of human genetics 2016-03-01 Lewy body dementia

    Autosomal-recessive early-onset parkinsonism is clinically and genetically heterogeneous.

  19. Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Acta neuropathologica communications 2016-02-25 Biomarkers

    The hTau40(AT) mice mimic pathological hallmarks of tauopathies including a cognitive phenotype combined with pronounced neuroinflammation visible by bioluminescence.

  20. Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Scientific reports 2016-02-18 TREM2 and immune genetics

    Studies have assessed individual components of a western diet, but no study has assessed the long-term, cumulative effects of a western diet on aging and Alzheimer's disease (AD).

  21. Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2016-02-18 Brain scans and imaging

    SUVR at 60-90 min after injection gave robust quantitation of (18)F-GE180, which correlated well with distribution volume ratios calculated from the entire recording and using a white matter reference region.

  22. Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Molecular neurodegeneration 2016-02-09 Disease mechanisms

    These findings indicate that metformin pro-aggregation effects mitigate the potential benefits arising from its dephosphorylating action, possibly leading to an overall increase of the risk of tauopathy in elderly diabetic patients.

  23. Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2016-01-01 Disease mechanisms

    The formation and deposition of tau protein aggregates is proposed to contribute to cognitive impairments in dementia by disrupting neuronal function in brain regions, including the hippocampus.

  24. Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. CNS & neurological disorders drug targets 2016-01-01 Inflammation and the immune system

    Chronic inflammation is characterized by longstanding microglial activation followed by sustained release of inflammatory mediators, which aid in enhanced nitrosative and oxidative stress.

  25. LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Current neuropharmacology 2016-01-01 Inflammation and the immune system

    Neuroinflammation is an important feature in the pathogenesis and progression of neurodegenerative diseases such as Alzheimer´s disease (AD), Parkinson´s disease (PD), frontotemporal dementia and amyotrophic lateral sclerosis.

  26. Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Alzheimer's research & therapy 2015-12-24 Cognitive tests and assessment

    Neuroinflammation and synaptic degeneration are major neuropathological hallmarks in Alzheimer's disease (AD).

  27. The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. The Journal of biological chemistry 2015-12-22 TREM2 and immune genetics

    The triggering receptor expressed on myeloid cells (TREM) 2 is a member of the immunoglobulin superfamily of receptors and mediates signaling in immune cells via engagement of its co-receptor DNAX-activating protein of 12 kDa (DAP12).

  28. Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular neurodegeneration 2015-12-21 Down syndrome and Alzheimer's

    In Alzheimer Disease (AD), the mechanistic connection of the two major pathological hallmarks, namely deposition of Amyloid-beta (Aβ) in the form of extracellular plaques, and the pathological changes of the intracellular protein Tau (such as phosphorylation, missorting, aggregation), is not well understood.

  29. Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The Journal of biological chemistry 2015-12-09 Risk genes beyond APOE

    Amyloid β (Aβ) damages neurons and triggers microglial inflammatory activation in the Alzheimer disease (AD) brain.

  30. A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. The Journal of biological chemistry 2015-11-09 Genetics

    Inflammasomes are high molecular weight protein complexes that assemble in the cytosol upon pathogen encounter.

  31. The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PloS one 2015-11-05 Disease mechanisms

    The perforant pathway projection from layer II of the entorhinal cortex to the hippocampal dentate gyrus is especially important for long-term memory formation, and is preferentially vulnerable to developing a degenerative tauopathy early in Alzheimer's disease (AD) that may spread over time trans-synaptically.

  32. The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Progress in neurobiology 2015-10-29 Risk genes beyond APOE

    Proteins belonging to the 'A Disintegrin And Metalloproteinase' (ADAM) family are membrane-anchored proteases that are able to cleave the extracellular domains of several membrane-bound proteins in a process known as 'ectodomain shedding'.

  33. Alterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Frontiers in cellular neuroscience 2015-10-23 Brain tissue and pathology

    Stress granules (SGs) are RNA-containing cytoplasmic foci formed in response to stress exposure.

  34. Astrocytic estrogen receptors and impaired neurotrophic responses in a rat model of perimenopause

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Frontiers in aging neuroscience 2015-09-29 Biomarkers

    In a perimenopausal model of middle-aged rats, the astrocyte estrogen receptor-alpha (ERa): ER-beta (ERb) ratio increased with the onset of acyclicity (constant estrus, CE) in association with impaired neurotrophic responses to estradiol (E2).

  35. The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. The Journal of biological chemistry 2015-09-15 Genetics

    The triggering receptor expressed on myeloid cells 2 (TREM2) is an Ig-like V-type receptor expressed by populations of myeloid cells in the central nervous system and periphery.

  36. Monomeric C-reactive protein--a key molecule driving development of Alzheimer's disease associated with brain ischaemia?

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Scientific reports 2015-09-03 Clinical safety

    Alzheimer's disease (AD) increases dramatically in patients with ischaemic stroke.

  37. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Nature neuroscience 2015-09-01 Lewy body dementia

    C9orf72 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

  38. Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Cell 2015-09-01 Lewy body dementia

    Stress granules are membrane-less organelles composed of RNA-binding proteins (RBPs) and RNA.

  39. Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cold Spring Harbor perspectives in biology 2015-09-01 Prevention and risk

    Exposure to stress is one of the best-known negative regulators of adult neurogenesis (AN).

  40. η-Secretase processing of APP inhibits neuronal activity in the hippocampus

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Nature 2015-08-31 Risk genes beyond APOE

    Alzheimer disease (AD) is characterized by the accumulation of amyloid plaques, which are predominantly composed of amyloid-β peptide.

  41. GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Nature 2015-08-26 Lewy body dementia

    The GGGGCC (G4C2) repeat expansion in a noncoding region of C9orf72 is the most common cause of sporadic and familial forms of amyotrophic lateral sclerosis and frontotemporal dementia.

  42. The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Nature 2015-08-26 Lewy body dementia

    The hexanucleotide repeat expansion (HRE) GGGGCC (G4C2) in C9orf72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

  43. TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Science (New York, N.Y.) 2015-08-01 Lewy body dementia

    Cytoplasmic aggregation of TDP-43, accompanied by its nuclear clearance, is a key common pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD).

  44. Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Biochemical pharmacology 2015-07-29 Inflammation and the immune system

    Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central nervous system, being expressed in neurons and non-neuronal cells, where they participate in a variety of physiological responses like memory, learning, locomotion, attention, among others.

  45. Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Antioxidants & redox signaling 2015-07-29 Inflammation and the immune system

    These data reveal a link between reduced glucocerebrosidase and the development of α-synucleinopathy and pathophysiological abnormalities in mice, and support the development of GCase therapeutics to reduce α-synucleinopathy in PD and related disorders.

  46. Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer's disease dementia: A phase 1 clinical trial

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia (New York, N. Y.) 2015-07-26 Clinical safety

    Administration of hUCB-MSCs into the hippocampus and precuneus by stereotactic injection was feasible, safe, and well tolerated.

  47. Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. The Journal of biological chemistry 2015-07-10 Genetics

    Alzheimer disease (AD) is characterized by the extracellular accumulation of amyloid β (Aβ), which is accompanied by a robust inflammatory response in the brain.

  48. Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cell death & disease 2015-06-18 Disease mechanisms

    Synaptic loss is one of the major features of Alzheimer's disease (AD) and correlates with the degree of dementia.

  49. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Neurobiology of disease 2015-06-17 Lewy body dementia

    Previous studies demonstrate that intrastriatal injections of fibrillar alpha-synuclein (α-syn) into mice induce Parkinson's disease (PD)-like Lewy body (LB) pathology formed by aggregated α-syn in anatomically interconnected regions and significant nigrostriatal degeneration.

  50. The function of RNA-binding proteins at the synapse: implications for neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cellular and molecular life sciences : CMLS 2015-06-06 Disease mechanisms

    The loss of synapses is a central event in neurodegenerative diseases.

From across this tag

9 of the 1,159 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts