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Newest in this topic

  1. What Do Sugar, Gila Monsters, and the Therapeutic Dance Have in Common With GLP-1RA, Stroke, and Dementia? 2026-09-25
  2. Myo-inositol as a spectroscopic marker of neuroinflammation in frontotemporal lobar degeneration 2026-09-20
  3. Laromestrocel preserves brain volume and cognitive function in Alzheimers disease by inhibiting neuroinflammation 2026-09-17

Studies

1,163 studies carry this tag.

Date range

1986 to 2026

Top journals

  • The Journal of biological chemistry 109
  • The Journal of neuroscience : the official journal of the Society for Neuroscience 42
  • Proceedings of the National Academy of Sciences of the United States of America 39
  • Neuron 28
  • Nature 23

365 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience 1995-01-01 Disease mechanisms

    We studied a synatophysin-like immunoreactivity in the hippocampal formation of patients with definite Alzheimer's disease, multi-infarct dementia, patients with no evidence of clinical dementia with neuropathological findings fulfilling the criteria of possible Alzheimer's disease, and age-matched nondemented controls.

  2. Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1994-07-01 Risk genes beyond APOE

    Biological effects related to cell growth, as well as a role in the pathogenesis of Alzheimer disease, have been ascribed to the beta-amyloid precursor protein (beta-APP).

  3. Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1993-10-01 Risk genes beyond APOE

    The beta-amyloid or beta/A4 peptides that accumulate as filamentous aggregates in the extracellular space of Alzheimer disease (AD) brains are derived from one or more alternatively spliced amyloid precursor proteins (APPs).

  4. Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1992-03-01 Risk genes beyond APOE

    The metabolic fate of the Alzheimer beta/A4 amyloid precursor protein (APP) includes intraamyloid proteolysis that leads to the production of secreted N-terminal and cell-associated C-terminal fragments.

  5. Reactive microglia/macrophages phagocytose amyloid precursor protein produced by neurons following neural damage

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of neuroscience research 1992-03-01 Biomarkers

    Kainic acid lesions of rat striatum caused an elevation of amyloid precursor protein (APP) immunoreactivity in neurons and neurites, some of which were then phagocytosed by reactive microglia/macrophages.

  6. Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain : a journal of neurology 1991-04-01 Disparities

    Antibodies to ubiquitin have been used to search for evidence of abnormal protein degradation in amyotrophic lateral sclerosis--motor neuron disease (ALS).

  7. Induction and regulation of interleukin-6 gene expression in rat astrocytes

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroimmunology 1990-12-01 Inflammation and the immune system

    Cells that produce interleukin-6 (IL-6) require the presence of signaling molecules since this cytokine is not normally constitutively expressed.

  8. Ammonia induced decrease in glial fibrillary acidic protein in cultured astrocytes

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neuropathology and experimental neurology 1990-07-01 Biomarkers

    Previous studies of human hepatic encephalopathy (HE) have shown decreased levels of glial fibrillary acidic protein (GFAP) in Alzheimer type II astrocytes.

  9. Astrocytic pathology of methionine sulfoximine-induced encephalopathy

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. Acta neuropathologica 1989-01-01 Biomarkers

    To investigate the roles imposed on astrocytes for glutamate metabolism, a specific inhibitor of glutamine synthetase (GS), methionine sulfoximine (MSO), was repeatedly administered to rats and histopathological changes were correlated with glycogen accumulation and the immunocytochemistry of GS and glial fibrillary acidic protein (GFAP).

  10. Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1988-12-01 Down syndrome and Alzheimer's

    Deposition of amyloid filaments serves as a pathologic hallmark for some neurodegenerative disorders.

  11. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Neurology 1988-08-01 Getting a diagnosis

    We detected large numbers of HLA-DR-positive reactive microglia (macrophages), along with Lewy bodies and free melanin, in the substantia nigra of all cases studied with Parkinson's disease (5) and parkinsonism with dementia (PD) (5).

  12. The role of astrocytes in hepatic encephalopathy

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neurochemical pathology 1987-02-01 Inflammation and the immune system

    The Alzheimer type II astrocyte change is the distinctive morphologic alteration in brain of humans and experimental animals succumbing to hepatic encephalopathy (HE).

  13. Glial fibrillary acidic protein and S-100 protein in human hepatic encephalopathy: immunocytochemical demonstration of dissociation of two glia-associated proteins

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Acta neuropathologica 1986-01-01 Biomarkers

    Immunocytochemical staining patterns for glial fibrillary acidic protein (GFAP) and S-100 protein (S100P) were compared in cerebral cortex, basal ganglia and white matter of eight cases with hepatic encephalopathy (HE), including four cases of Wilson's disease and four of liver cirrhosis, and of eight age-matched controls, using the peroxidase-antiperoxidase method on adjacent paraffin sections.

From across this tag

10 of the 1,159 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts