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Home › Research › Topic

Disease mechanisms in lab and animal studies

1,352 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer's Disease Mutant of APP

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Scientific reports 2019-03-29 Biomarkers

    Cleavage of the amyloid precursor protein's (APP) transmembrane domain (TMD) by γ-secretase is a crucial step in the aetiology of Alzheimer's Disease (AD).

  2. Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesis

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neuroscience letters 2019-03-16 Disease mechanisms

    Several lines of evidence have shown that defects in the endo-lysosomal autophagy degradation pathway and the ubiquitin-proteasome system play a role in Alzheimer's Disease (AD) pathogenesis and pathophysiology.

  3. Presenilins and γ-Secretase in Membrane Proteostasis

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Cells 2019-03-01 Disease mechanisms

    The presenilin (PS) proteins exert a crucial role in the pathogenesis of Alzheimer disease (AD) by mediating the intramembranous cleavage of amyloid precursor protein (APP) and the generation of amyloid β-protein (Aβ).

  4. Iron treatment inhibits Aβ42 deposition in vivo and reduces Aβ42/Aβ40 ratio

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Biochemical and biophysical research communications 2019-02-18 Biomarkers

    Alzheimer's disease (AD) is characterized by the formation of extracellular amyloid plaques containing the amyloid β-protein (Aβ) within the parenchyma of the brain.

  5. Synergistic Effect of Amyloid-β and Tau Disrupts Neural Circuits

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. ACS chemical neuroscience 2019-01-31 Drug development

    Alzheimer's disease (AD) is characterized by the coexistence of amyloid-β (Aβ) plaques and tau-based neurofibrillary tangles.

  6. Dendritic spines: Revisiting the physiological role

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Progress in neuro-psychopharmacology & biological psychiatry 2019-01-15 Disease mechanisms

    Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily localized in the excitatory synapses.

  7. Anti-Tau Trials for Alzheimer's Disease: A Report from the EU/US/CTAD Task Force

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. The journal of prevention of Alzheimer's disease 2019 Drug development

    Efforts to develop effective disease-modifying treatments for Alzheimer's disease (AD) have mostly targeted the amyloid β (Aβ) protein; however, there has recently been increased interest in other targets including phosphorylated tau and other forms of tau.

  8. The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Cells 2018-12-20 Disease mechanisms

    In normal physiological condition, the maintenance of cellular proteostasis is a prerequisite for cell growth, functioning, adapting to changing micro-environments, and responding to extracellular stress.

  9. Proteomic analysis of protein homeostasis and aggregation

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of proteomics 2018-12-06 Disease mechanisms

    Protein homeostasis (proteostasis) refers to the ability of cells to preserve the correct balance between protein synthesis, folding and degradation.

  10. Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2018-12-05 Disease mechanisms

    Dozens of genes have been implicated in late onset Alzheimer's disease (AD) risk, but none has a defined mechanism of action in neurons.

  11. Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Cell death and differentiation 2018-11-15 Disease mechanisms

    Imbalance of neuronal proteostasis associated with misfolding and aggregation of Tau protein is a common neurodegenerative feature in Alzheimer's disease (AD) and other Tauopathies.

  12. Prolonged Drug-Releasing Fibers Attenuate Alzheimer's Disease-like Pathogenesis

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. ACS applied materials & interfaces 2018-10-22 Drug development

    Delivering drugs and agents to the brain is a huge challenge, especially for chronic neurodegenerative disorders, such as Alzheimer's disease (AD).

  13. Fighting the Cause of Alzheimer's and GNE Myopathy

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Frontiers in neuroscience 2018-10-15 Disease mechanisms

    Age is the common risk factor for both neurodegenerative and neuromuscular diseases.

  14. Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neurobiology of aging 2018-09-05 Risk factors

    Mutations in fused in sarcoma (Fus) cause familial amyotrophic lateral sclerosis (ALS) and occasionally frontotemporal dementia.

  15. Cellular Proteostasis in Neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Molecular neurobiology 2018-09-04 Disease mechanisms

    The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated through a vast network of biochemical pathways.

  16. Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Acta neuropathologica communications 2018-08-22 Drug development

    Tau, the main component of the neurofibrillary tangles (NFTs), is an attractive target for immunotherapy in Alzheimer's disease (AD) and other tauopathies.

  17. Epileptic seizures in autosomal dominant forms of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Seizure 2018-07-19 Risk genes beyond APOE

    Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder and represents the most common form of dementia in the elderly.

  18. Klotho at the Edge of Alzheimer's Disease and Senile Depression

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Molecular neurobiology 2018-07-05 Risk factors

    Klotho, encoded by the KL gene, is a single-pass transmembrane protein and a circulating factor that plays a key role in cellular metabolism and body homeostasis and has been associated with age-related diseases.

  19. Benzofuran and Indole: Promising Scaffolds for Drug Development in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. ChemMedChem 2018-06-19 Treatments

    Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically accepted treatment to cure or halt its progression.

  20. CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Cell reports 2018-06-12 Disease mechanisms

    Alzheimer's disease (AD) is emerging as a synaptopathology driven by metaplasticity.

  21. SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Cell death & disease 2018-05-01 Disease mechanisms

    Neutral sphingomyelinase smpd3 is most abundantly expressed in neurons of brain.

  22. Protein aggregates and proteostasis in aging: Amylin and β-cell function

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Mechanisms of ageing and development 2018-03-23 Disease mechanisms

    The ubiquitin-proteasomal-system (UPS) and the autophagy-lysosomal-system (ALS) are both highly susceptible for disturbances leading to the accumulation of cellular damage.

  23. Pin1 mediates Aβ42-induced dendritic spine loss

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Science signaling 2018-03-20 Disease mechanisms

    Early-stage Alzheimer's disease is characterized by the loss of dendritic spines in the neocortex of the brain.

  24. TDP-43 Prions

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Cold Spring Harbor perspectives in medicine 2018-03-01 Brain tissue and pathology

    The most common neurodegenerative diseases, such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis, are all protein-misfolding diseases and are characterized by the presence of disease-specific protein aggregates in affected neuronal cells.

  25. Synaptic plasticity modulation by circulating peptides and metaplasticity: Involvement in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Pharmacological research 2018-02-06 Disease mechanisms

    Synaptic plasticity is a cellular process involved in learning and memory whose alteration in its two main forms (Long Term Depression (LTD) and Long Term Potentiation (LTP)), is observed in most brain pathologies, including neurodegenerative disorders such as Alzheimer's disease (AD).

From across this topic

10 of the 1,352 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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