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Home › Research › Topic

Disease mechanisms in lab and animal studies

1,352 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Development of LNA Gapmer Oligonucleotide-Based Therapy for ALS/FTD Caused by the C9orf72 Repeat Expansion

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Methods in molecular biology (Clifton, N.J.) 2020 Drug development

    Several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), have a complex genetic background, in addition to cases where the disease appears to manifest sporadically.

  2. Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current Alzheimer research 2020 Drug development

    LMTM given alone increased hippocampal Acetylcholine (ACh) levels, glutamate release from synaptosomal preparations, synaptophysin levels in multiple brain regions and mitochondrial complex IV activity, reduced tau pathology, partially restored ChAT immunoreactivity in the basal forebrain and reversed deficits in spatial learning.

  3. Muscone Ameliorates Synaptic Dysfunction and Cognitive Deficits in APP/PS1 Mice

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of Alzheimer's disease : JAD 2020 Disease mechanisms

    Mus treatment attenuated memory dysfunction, reduced Aβ level, and enhanced synaptic plasticity in APP/PS1 mice.

  4. The Ubiquitin System in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Advances in experimental medicine and biology 2020 Disease mechanisms

    Alzheimer's disease (AD) is the most common form of dementia, most prevalent in the elderly population and has a significant impact on individuals and their family as well as the health care system and the economy.

  5. Altered Proteostasis in Neurodegenerative Tauopathies

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Advances in experimental medicine and biology 2020 Disease mechanisms

    Tauopathies are a heterogeneous group of neurodegenerative dementias involving perturbations in the levels, phosphorylation or mutations of the neuronal microtubule-binding protein Tau.

  6. Reduced expression of dMyc mitigates TauV337M mediated neurotoxicity by preventing the Tau hyperphosphorylation and inducing autophagy in Drosophila

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neuroscience letters 2019-11-09 Disease mechanisms

    Tauopathies such as Alzheimer's disease (AD), Pick's disease (PiD), Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) etc. represent a group of age-related neurodegenerative disorders in which tau protein loses its normal conformation mostly due to hyperphosphorylation and subsequent formation of the aggregates of defined shapes, known as Neurofibrillary Tangles (NFTs).

  7. From EST to structure models for functional inference of APP, BACE1, PSEN1, PSEN2 genes

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Bioinformation 2019-10-31 Risk genes beyond APOE

    Successive oxidative stress and biochemical changes results in neuronal death and neuritic plaques growth in Alzheimer's disease (AD).

  8. Autophagy and synaptic plasticity: epigenetic regulation

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current opinion in neurobiology 2019-10-18 Disease mechanisms

    In neurons, autophagy is crucial to proper axon guidance, vesicular release, dendritic spine architecture, spine pruning and synaptic plasticity and, when dysregulated, is associated with brain disorders, including autism spectrum disorders, and neurodegenerative diseases such as Parkinson's and Alzheimer's disease.

  9. Pathogenic Mechanisms and Therapy Development for C9orf72 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2019-10 Drug development

    In 2011, a hexanucleotide repeat expansion in the first intron of the C9orf72 gene was identified as the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

  10. Modeling α-Synuclein Propagation with Preformed Fibril Injections

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of movement disorders 2019-09-30 Brain tissue and pathology

    The aggregation of α-synuclein (α-syn) has been implicated in the pathogenesis of many neurodegenerative disorders, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).

  11. Microbiome Influence in the Pathogenesis of Prion and Alzheimer's Diseases

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. International journal of molecular sciences 2019-09-23 Disease mechanisms

    Misfolded and abnormal β-sheets forms of wild-type proteins, such as cellular prion protein (PrPC) and amyloid beta (Aβ), are believed to be the vectors of neurodegenerative diseases, prion and Alzheimer's disease (AD), respectively.

  12. [Anti-tau therapies-what can be expected?]

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Der Nervenarzt 2019-09 Drug development

    Alzheimer's disease is histopathologically characterized by aggregation of two proteins, namely amyloid-beta peptide and tau protein.

  13. Disease-modifying therapy for proteinopathies: Can the exception become the rule?

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Progress in molecular biology and translational science 2019-08-07 Drug development

    Disease-modifying therapies for proteinopathies are urgently needed yet clinical trials for the major neurodegenerative diseases, Alzheimer's and Parkinson's, have been failing at an alarming rate leaving patients and caregivers scrambling for any sign of hope.

  14. Identification of AV-1451 as a Weak, Nonselective Inhibitor of Monoamine Oxidase

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. ACS chemical neuroscience 2019-08-05 Brain scans and imaging

    [18F]AV-1451 is one of the most widely used radiotracers for positron emission tomography (PET) imaging of tau protein aggregates in neurodegenerative disorders.

  15. [Antisense therapies for neurological diseases]

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Der Nervenarzt 2019-08 Drug development

    Despite identification of many genes causing neurodegenerative diseases in the last decades, development of disease-modifying treatments has been slow.

  16. Targeting Synaptic Plasticity in Experimental Models of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Frontiers in pharmacology 2019-07-16 Disease mechanisms

    Long-term potentiation (LTP) and long-term depression (LTD) of hippocampal synaptic transmission represent the principal experimental models underlying learning and memory.

  17. In search of pathogenic amyloid β-peptide in familial Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Progress in molecular biology and translational science 2019-07-13 Risk genes beyond APOE

    Early-onset familial Alzheimer's disease (FAD) is pathologically and clinically similar to the more common late-onset sporadic form of the disease.

  18. Glia-specific autophagy dysfunction in ALS

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Seminars in cell & developmental biology 2019-05-28 Disease mechanisms

    Neuronal cell death is the main pathological feature of chronic neurodegenerative diseases (NDs) such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

  19. Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. FEBS letters 2019-05-27 Genetics

    Apolipoprotein E (APOE) genotype determines Alzheimer's disease (AD) susceptibility, with the APOE ε4 allele being an established risk factor for late-onset AD.

  20. Emerging drugs for progressive supranuclear palsy

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Expert opinion on emerging drugs 2019-05-20 Drug development

    Progressive supranuclear palsy (PSP) is a common cause of atypical parkinsonism and a rapidly progressive disease that greatly burdens both patients and caregivers.

  21. Autophagy Dysfunction in Alzheimer's Disease: Mechanistic Insights and New Therapeutic Opportunities

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Biological psychiatry 2019-05-20 Disease mechanisms

    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory loss due to aberrant accumulation of misfolded proteins inside and outside neurons and glial cells, leading to a loss of cellular protein homeostasis.

  22. LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Biochemical Society transactions 2019-05-13 Prevention trials

    The identification of genetic forms of Parkinson's disease (PD) has tremendously expanded our understanding of the players and mechanisms involved.

  23. Loss of proteins associated with amyotrophic lateral sclerosis affects lysosomal acidification via different routes

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Autophagy 2019-04-28 Disease mechanisms

    Abnormal accumulation of proteins is a hallmark of a variety of neurological diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

  24. Formaldehyde, Epigenetics, and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Chemical research in toxicology 2019-04-19 Drug development

    Alzheimer's disease (AD) is the most common form of dementia.

  25. Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Free radical biology & medicine 2019-04-17 Disease mechanisms

    In recent years, a particular interest has focused on the accumulation of fatty acids with very long chains (VLCFA) in the occurrence of neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis or dementia.

From across this topic

10 of the 1,352 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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