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Home › Research › Topic

Disease mechanisms in lab and animal studies

1,352 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of cell biology 2005-10-03 Risk genes beyond APOE

    Macroautophagy, which is a lysosomal pathway for the turnover of organelles and long-lived proteins, is a key determinant of cell survival and longevity.

  2. Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 2005-09-15 How common it is

    Several epidemiological studies indicate that moderate consumption of wine is associated with a lower incidence of Alzheimer's disease.

  3. MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of cell biology 2004-10-04 Brain scans and imaging

    Microtubule-dependent transport of vesicles and organelles appears saltatory because particles switch between periods of rest, random Brownian motion, and active transport.

  4. Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2004-09-01 Drug development

    Alzheimer's disease (AD) is a progressive amnestic dementia that involves post-translational hyperphosphorylation, enzymatic cleavage, and conformational alterations of the microtubule-associated protein tau.

  5. Hsp70 Reduces α-Synuclein Aggregation and Toxicity

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 2004-06-01 Brain tissue and pathology

    Aggregation and cytotoxicity of misfolded alpha-synuclein is postulated to be crucial in the disease process of neurodegenerative disorders such as Parkinson's disease and DLB (dementia with Lewy bodies).

  6. Axonal mitochondrial transport and potential are correlated

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Cell Science 2004-05-24 Disease mechanisms

    Disruption of axonal transport leads to a disorganized distribution of mitochondria and other organelles and is thought to be responsible for some types of neuronal disease.

  7. GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Molecular psychiatry 2004-05-01 Drug development

    The tauopathies are a group of disorders characterised by aggregation of the microtubule-associated protein tau and include Alzheimer's disease (AD) and the fronto-temporal dementias (FTD).

  8. Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Neuroscience 2004-04-07 Disease mechanisms

    Multiple lines of evidence implicate beta-amyloid (Abeta) in the pathogenesis of Alzheimer's disease (AD), but the mechanisms whereby Abeta is involved remain unclear.

  9. Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of neurology 2004-02-01 Risk genes beyond APOE

    Genomic triplication of the alpha-synuclein gene recently has been associated with familial Parkinson's disease in the Spellman-Muenter kindred.

  10. β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Neuroscience 2004-01-14 Disease mechanisms

    Beta-amyloid (betaA) peptide is strongly implicated in the neurodegeneration underlying Alzheimer's disease, but the mechanisms of neurotoxicity remain controversial.

  11. Structural Insights and Biological Effects of Glycogen Synthase Kinase 3-specific Inhibitor AR-A014418

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 2003-11-01 Risk factors

    Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer's disease.

  12. Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of Cell Biology 2003-04-14 Disease mechanisms

    Alzheimer's amyloid precursor protein 695 (APP) is a plasma membrane protein, which is known to be the source of the toxic amyloid beta (Abeta) peptide associated with the pathogenesis of Alzheimer's disease (AD).

  13. A Broken α-Helix in Folded α-Synuclein

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 2003-04-01 Brain tissue and pathology

    alpha-Synuclein is a small cytosolic protein of presynaptic nerve terminals composed of seven 11-residue repeats and a hydrophilic tail. alpha-Synuclein misfolding and dysfunction may contribute to the pathogenesis of Parkinson's disease and neurodegenerative dementias, but its normal folding and function are unknown.

  14. Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Molecular psychiatry 2003-02-01 Drug development

    Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which is probably caused by the cytotoxic effect of the amyloid beta-peptide (Abeta).

  15. Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 2002-10-01 Risk factors

    Beta-amyloid (Abeta) 1-42, implicated in the pathogenesis of Alzheimer's disease, forms an oligomeric complex that binds copper at a CuZn superoxide dismutase-like binding site.

  16. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature neuroscience 2002-05-01 Tau biomarkers

    We have previously shown that chronic treatment with the monoclonal antibody m266, which is specific for amyloid beta-peptide (Abeta), increases plasma concentrations of Abeta and reduces Abeta burden in the PDAPP transgenic mouse model of Alzheimer's disease (AD).

  17. Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of cell biology 2002-03-18 Risk genes beyond APOE

    We studied the effect of microtubule-associated tau protein on trafficking of vesicles and organelles in primary cortical neurons, retinal ganglion cells, and neuroblastoma cells.

  18. The synucleins

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Genome biology 2001-12-20 Brain scans and imaging

    Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors.

  19. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature neuroscience 2001-09-01 Risk genes beyond APOE

    Several pathogenic Alzheimer's disease (AD) mutations have been described, all of which cause increased amyloid beta-protein (Abeta) levels.

  20. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neuron 2001-06-01 Biomarkers

    Inhibition of neocortical beta-amyloid (Abeta) accumulation may be essential in an effective therapeutic intervention for Alzheimer's disease (AD).

  21. Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurology 2001-01-01 Cognitive tests and assessment

    The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed.

  22. α-Synuclein Membrane Interactions and Lipid Specificity

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 2000-11-01 Risk genes beyond APOE

    With the discovery of missense mutations (A53T and A30P) in alpha-synuclein (alpha-Syn) in several families with early onset familial Parkinson's disease, alpha-Syn aggregation and fibril formation have been thought to play a role in the pathogenesis of alpha-synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

  23. Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain research 2000-10-01 Biomarkers

    HIV-associated dementia complex is a serious disabling disease characterized by cognitive, behavioral and motor dysfunction.

  24. Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of neurology 2000-02-01 Treatments

    Human immunodeficiency virus type 1 (HIV-1) proteins Tat and gp120 have been implicated in the pathogenesis of dementia associated with HIV infection.

  25. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Proceedings of the National Academy of Sciences 1999-11-23 Vascular contributions

    Transgenic mice that overexpress mutant human amyloid precursor protein (APP) exhibit one hallmark of Alzheimer's disease pathology, namely the extracellular deposition of amyloid plaques.

From across this topic

10 of the 1,352 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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