Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
-
The reduction of tau or hyperphosphorylated tau (p-tau) has been proposed as a therapeutic strategy for Alzheimer's disease (AD) and frontotemporal dementia (FTD).
-
Accumulation of phosphorylated tau (p-tau) has long been an underappreciated hallmark of Alzheimer's disease.
-
As the population ages, Alzheimer's disease (AD), the most common neurodegenerative disease in elderly people, will impose social and economic burdens to the world.
-
The synaptic regulator, kalirin, plays a key role in synaptic plasticity and formation of dendritic arbors and spines.
-
Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson's disease (PD).
-
The aberrant accumulation of disease-specific protein aggregates accompanying cognitive decline is a pathological hallmark of age-associated neurological disorders, also termed as proteinopathies, including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and multiple sclerosis.
-
41/100
Protein prenylation is a post-translational lipid modification that governs a variety of important cellular signaling pathways, including those regulating synaptic functions and cognition in the nervous system.
-
Accumulation of phosphorylated tau is a key pathological feature of Alzheimer's disease.
-
Senolytics are a class of drugs that selectively clear senescent cells (SC).
-
Recent studies have revealed a correlation between aging-related hearing loss and the likelihood of developing Alzheimer Disease.
-
Our findings identify CatD as the principal intracellular Aβ-degrading protease identified to date, one that regulates Aβ42/40 ratios via differential degradation of Aβ42 vs. Aβ40.
-
Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by severe cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary tangles.
-
The hippocampus is important for memory formation and is severely affected in the brain with Alzheimer disease (AD).
-
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by impaired cognitive function due to progressive loss of neurons in the brain.
-
Our findings highlight sexual dimorphism in the behavior, neuropathology, and plasma proteins in tau P301S transgenic AD mice, indicating that the use of male P301S transgenic mice may be more suitable for assessing anti-phosphorylated tau therapeutic strategies for AD and related tauopathies, and the MIP-3α may be a new potential plasma biomarker.
-
Alzheimer's disease (AD) is a debilitating neurodegenerative disease that causes a progressive decline in memory, language and problem solving.
-
Cellular senescence is a homeostatic biological process characterized by a permanent state of cell cycle arrest that can contribute to the decline of the regenerative potential and function of tissues.
-
Tau deposition in the brain is a pathological hallmark of many neurodegenerative disorders, including Alzheimer's disease (AD).
-
Lipids play a more significant role in Parkinson's disease and its related brain disorders than is currently recognized, supporting a "lipid cascade".
-
The postsynaptic density (PSD) is a complex subcellular domain important for postsynaptic signaling, function, and plasticity.
-
Protein misfolding into amyloid fibrils is linked to more than 40 as yet incurable cell- and neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and type 2 diabetes.
-
Alzheimer's disease (AD) is the most frequent cause of dementia in the elderly.
-
41/100
Mitochondria vary in morphology and function in different tissues; however, little is known about their molecular diversity among cell types.
-
Curli amyloid fibrils secreted by Enterobacteriaceae mediate host cell adhesion and contribute to biofilm formation, thereby promoting bacterial resistance to environmental stressors.
-
The Alzheimer's disease (AD) therapeutic research is yielding a large number of potent molecules.
From across this topic
10 of the 1,352 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain
- Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons
- Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory
- Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease
- Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
- Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy
- Alzheimer's disease and sleep disorders: A bidirectional relationship
- Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
- Tau-targeting therapies for Alzheimer disease
- Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation