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Home › Research › Topic

Disease mechanisms in lab and animal studies

1,352 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurodegeneration 2019-07-22 Getting a diagnosis

    Alpha-synuclein (αS) is the major constituent of Lewy bodies and a pathogenic hallmark of all synucleinopathathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).

  2. Discovery and preclinical characterization of [ 18 F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. European journal of nuclear medicine and molecular imaging 2019-07-01 Brain scans and imaging

    [ 18 F]PI-2620 was selected for clinical validation.

  3. Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific reports 2019-06-25 Drug development

    The microtubule-associated protein tau is an attractive therapeutic target for the treatment of Alzheimer's disease and related tauopathies as its aggregation strongly correlates with disease progression and is considered a key mediator of neuronal toxicity.

  4. Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecules (Basel, Switzerland) 2019-06-22 Drug development

    The amyloid-β (Aβ) peptide and tau protein are thought to play key neuropathogenic roles in Alzheimer's disease (AD).

  5. GBA , Gaucher Disease, and Parkinson's Disease: From Genetic to Clinic to New Therapeutic Approaches

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cells 2019-04-19 Brain scans and imaging

    Parkinson's disease (PD) is the second most common degenerative disorder.

  6. Antisense oligonucleotides: A primer

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurology. Genetics 2019-04-01 Drug development

    There are few disease-modifying therapeutics for neurodegenerative diseases, but successes on the development of antisense oligonucleotide (ASO) therapeutics for spinal muscular atrophy and Duchenne muscular dystrophy predict a robust future for ASOs in medicine.

  7. BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Pharmaceuticals (Basel, Switzerland) 2019-03-19 Treatments

    Alzheimer's disease (AD) is a growing global health concern with a massive impact on affected individuals and society.

  8. Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Accounts of Chemical Research 2019-03-07 Genetics

    Hundreds of proteins are known to be citrullinated and hypercitrullination is associated with autoimmune diseases including rheumatoid arthritis (RA), lupus, ulcerative colitis (UC), Alzheimer's disease, multiple sclerosis (MS), and certain cancers.

  9. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature neuroscience 2019-02-11 Inflammation and the immune system

    Accumulation of damaged mitochondria is a hallmark of aging and age-related neurodegeneration, including Alzheimer's disease (AD).

  10. The Role of NMDA Receptors in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in neuroscience 2019-02-08 Treatments

    In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination.

  11. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science advances 2019-01-23 Inflammation and the immune system

    Porphyromonas gingivalis , the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer's disease patients.

  12. A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The Journal of cell biology 2019-01-09 Biomarkers

    Intramembrane proteolysis of transmembrane substrates by the presenilin-γ-secretase complex is preceded and regulated by shedding of the substrate's ectodomain by α- or β-secretase.

  13. Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular & Cellular Proteomics 2019-01-03 Genetics

    In BriefIn the search for biomarkers of synapse loss associated with Alzheimer's disease (AD), we used shotgun proteomics to identify a panel of 9 synaptic proteins detectable in human cerebrospinal fluid (CSF).Expression at the human synapse was verified using super resolution microscopy.

  14. Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. PloS one 2018-12-17 Biomarkers

    Human mini-brains (MB) are cerebral organoids that recapitulate in part the complexity of the human brain in a unique three-dimensional in vitro model, yielding discrete brain regions reminiscent of the cerebral cortex.

  15. SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA)

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's research & therapy 2018-11-28 Treatments

    Based on the improved efficacy/safety profile in non-clinical models of SAR228810, a first-in-man single and multiple dose administration clinical study has been initiated in AD patients.

  16. Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Drug delivery 2018-11-01 Treatments

    Alzheimer's disease is a neurodegenerative disorder mainly characterized by β-amyloid deposit and tau hyperphosphorylation with no curative treatments.

  17. Tau protein aggregation is associated with cellular senescence in the brain

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Aging cell 2018-10-11 Genetics

    Tau protein accumulation is the most common pathology among degenerative brain diseases, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP), traumatic brain injury (TBI), and over twenty others.

  18. Modeling amyloid beta and tau pathology in human cerebral organoids

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular psychiatry 2018-08-31 Down syndrome and Alzheimer's

    The typical abnormalities observed in the brain of Alzheimer's disease (AD) patients include synaptic alterations, neuronal death, brain inflammation, and the accumulation of protein aggregates in the form of amyloid plaques and neurofibrillary tangles.

  19. Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Translational psychiatry 2018-08-14 Biomarkers

    Alzheimer's disease (AD) represents a major healthcare burden with no effective treatment.

  20. Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. BMC neuroscience 2018-07-28 Biomarkers

    App NL/NL and App NL-G-F/NL-G-F mice exhibit behavioral changes associated with non-cognitive, emotional domains before the onset of definitive cognitive deficits.

  21. Cognitive Decline, Dementia, Alzheimer's Disease and Presbycusis: Examination of the Possible Molecular Mechanism

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in neuroscience 2018-06-08 Risk factors

    The incidences of presbycusis and dementia are high among geriatric diseases.

  22. Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2018-05-31 Treatments

    Progressive accumulation of misfolded amyloid proteins in intracellular and extracellular spaces is one of the principal reasons for synaptic damage and impairment of neuronal communication in several neurodegenerative diseases.

  23. Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Aging cell 2018-05-10 Drug development

    Misfolded and hyperphosphorylated tau accumulates in several neurodegenerative disorders including Alzheimer's disease, frontotemporal dementia with Parkinsonism, corticobasal degeneration, progressive supranuclear palsy, Down syndrome, and Pick's disease.

  24. Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific reports 2018-04-23 Treatments

    Aducanumab, a human-derived antibody targeting amyloid-β (Aβ), is in Phase 3 clinical trials for the treatment of Alzheimer's disease.

  25. Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APP NL-F/NL-F knock-in mice

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific reports 2018-04-19 Biomarkers

    Amyloid pathology occurs early in Alzheimer's disease (AD), and has therefore been the focus of numerous studies.

From across this topic

10 of the 1,352 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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