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Home › Research › Topics › apolipoprotein

apolipoprotein

1,613 studies tagged apolipoprotein, dated 1982-09-01 to 2026-10-27. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. ApoE4 and Psychosis in Neurodegenerative and Non-Neurodegenerative Disease: A Scoping Review 2026-10-27
  2. Multimodal mediators connecting APOE4 to dementia 2026-10-21
  3. Reproductive Aging, FSH, and Apolipoprotein Biology in Alzheimer’s Disease 2026-10-19

Studies

1,613 studies carry this tag.

Date range

1982 to 2026

Top journals

  • Neurology 93
  • The Journal of biological chemistry 68
  • Proceedings of the National Academy of Sciences of the United States of America 52
  • Archives of neurology 43
  • Neurobiology of aging 38

457 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Nature 1995-06-01 Genetics

    Researchers isolated transcripts from a chromosomal region linked to an aggressive form of Alzheimer's disease and identified a novel gene transcript.

  2. Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals

    ✓ Peer-reviewed alzhub usefulness score 68 out of 100. JAMA 1995-04-01 Getting a diagnosis

    These data suggest the following: (1) patients with mild cognitive impairment can be clinically defined, (2) many members of this group progress to Alzheimer's disease, and (3) APOE epsilon 4 allele status appears to be a strong predictor of clinical progression.

  3. A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Neuroscience letters 1995-03-01 Genetics

    We measured the activities of choline acetyltransferase (ChAT) in the post mortem frontal cortex in 32 Alzheimer's disease (AD) patients with different apolipoprotein E (apoE) genotypes.

  4. Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Brain research. Molecular brain research 1995-03 Genetics

    We have investigated the effect of genotypes of apolipoprotein E (ApoE) on the pathologies found in Alzheimer's disease (AD) and its related gene expression in 38 aged human brains obtained from consecutive autopsied cases.

  5. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. JAMA 1995-03-01 Genetics

    These results suggest that the inheritance of APOE epsilon 4 is associated with reduced cerebral parietal metabolism and increased asymmetry in non-demented relatives at risk for probable AD.

  6. Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of biological chemistry 1995-03-01 Tau biomarkers

    Microtubule-associated protein tau is abnormally hyperphosphorylated in the brain of patients with Alzheimer disease and in this form is the major protein subunit of the paired helical filaments (PHF), the most prominent lesion of the disease.

  7. Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1995-03-01 Risk genes beyond APOE

    In Alzheimer disease, a combination of genetic predisposition and environmental factors may contribute to changes in beta-amyloid precursor protein (APP) expression, beta-amyloid peptide deposition, and neuronal loss.

  8. Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of biological chemistry 1995-03-01 Risk genes beyond APOE

    The Alzheimer amyloid precursor protein (APP) undergoes complex processing resulting in the production of a 4-kDa amyloid peptide (A beta) which has been implicated in the pathogenesis of Alzheimer's disease.

  9. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Nature 1995-02-01 Risk genes beyond APOE

    Alzheimer's disease (AD) is the most common cause of progressive intellectual failure in aged humans.

  10. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1995-01-01 Genetics

    The apolipoprotein E4 (APOE4) allele is associated with an early age of onset of the nonfamilial form of Alzheimer disease (AD) and with increased beta protein amyloid deposition in the brain.

  11. Decreased phospholipase A2 activity in Alzheimer brains

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Biological psychiatry 1995-01-01 Risk genes beyond APOE

    Phospholipase A2 (PLA2) is a key-enzyme in the metabolism of membrane phospholipids.

  12. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in neurosciences 1994-12-01 Genetics

    Recent evidence indicates that apolipoprotein E (ApoE) plays a central role in the hippocampal response to injury.

  13. Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1994-12-01 Risk genes beyond APOE

    The 39- to 43-amino acid amyloid beta-protein (A beta), which is progressively deposited in cerebral plaques and blood vessels in Alzheimer disease (AD), is secreted by cultured human cells during normal metabolism.

  14. Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Archives of neurology 1994-12-01 Genetics

    The apoE epsilon 4 allele may be associated with decreased cognitive function in discordant twin pairs.

  15. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Nature 1994-11-01 Genetics

    The protease inhibitor alpha 1-antichymotrypsin and the lipid transport protein apolipoprotein E (apoE) are intimately associated with the 42-amino-acid beta-peptide (A beta) in the filamentous amyloid deposits of Alzheimer's disease.

  16. Conformation and fibrillogenesis of Alzheimer A beta peptides with selected substitution of charged residues

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of molecular biology 1994-11-01 Risk genes beyond APOE

    A key pathological feature of Alzheimer's disease (AD) is the formation and accumulation of amyloid fibers within the neurophil as senile plaques and in the walls of cerebral and meningeal blood vessels.

  17. Gene expression in Alzheimer neocortex as a function of age and pathologic severity

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. Neurobiology of aging 1994-11-01 Biomarkers

    Previous studies have shown a marked decline in neuronal and an increase in glial gene expression in Alzheimer's disease (AD) neocortex.

  18. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1994-11-01 Genetics

    The apolipoprotein E (apoE) type 4 allele (APOE4) is a susceptibility gene for late-onset familial and sporadic Alzheimer disease.

  19. Non-fibrillar beta-amyloid protein is associated with smooth muscle cells of vessel walls in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neuropathology and experimental neurology 1994-11-01 Risk genes beyond APOE

    Meningeal blood vessels were studied in Alzheimer disease (AD) and control brain specimens obtained from autopsies within 16 hours after death.

  20. S100 beta protein expression in Alzheimer disease: potential role in the pathogenesis of neuritic plaques

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroscience research 1994-11-01 Biomarkers

    Increased synthesis and release of S100 beta protein from activated astrocytes has been implicated in the overgrowth of dystrophic neurites in neuritic plaques in Alzheimer disease (AD).

  21. Apolipoprotein E epsilon 4 allele in Alzheimer's disease and vascular dementia

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Dementia (Basel, Switzerland) 1994-09-01 Genetics

    The frequency of the epsilon 4 allele of the apolipoprotein E (apoE) is increased in familial and sporadic late-onset Alzheimer's disease, but its prevalence in non-Alzheimer dementias in Caucasian populations is unknown.

  22. Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Neuroscience 1994-09-01 Inflammation and the immune system

    The aetiology and pathogenesis of Alzheimer's disease are currently poorly understood, but symptomatic disease is associated with amyloid plaques, neurofibrillary tangles, neuronal loss and numerous alterations of neurotransmitter systems in the CNS.

  23. Isoform-specific binding of apolipoprotein E to beta-amyloid

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 1994-09-01 Genetics

    Apolipoprotein E (apoE), particularly the e4 allele, is genetically linked to the incidence of Alzheimer's disease.

  24. Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1994-09-01 Genetics

    Neuropathological findings in three aged chimpanzees were compared with those in rhesus monkeys and individuals with Alzheimer disease.

  25. Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1994-08-01 Risk genes beyond APOE

    The Alzheimer A beta amyloid peptide (A beta) is the principal proteinaceous component of amyloid associated with Alzheimer disease (AD).

  26. Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Neuroscience letters 1994-07-01 Genetics

    Recent data have demonstrated genetic disequilibrium between inheritance of the apolipoprotein E (apoE) epsilon 4 allele and increased risk of Alzheimer disease.

  27. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neuron 1994-07-01 Brain tissue and pathology

  28. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Nature genetics 1994-06-01 Genetics

    Gene dosage of the apolipoprotein E (APOE) epsilon 4 allele is a major risk factor for familial Alzheimer disease (AD) of late onset (after age 60).

  29. An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Science 1994-05-27 Risk genes beyond APOE

    Normal processing of the amyloid beta protein precursor (beta APP) results in secretion of a soluble 4-kilodalton protein essentially identical to the amyloid beta protein (A beta) that forms insoluble fibrillar deposits in Alzheimer's disease.

  30. Advanced glycation end products contribute to amyloidosis in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1994-05-01 Disease mechanisms

    Alzheimer disease (AD) is characterized by deposits of an aggregated 42-amino-acid beta-amyloid peptide (beta AP) in the brain and cerebrovasculature.

  31. Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Nature genetics 1994-05-01 Brain tissue and pathology

    Several studies have reported an association of the apolipoprotein E allele epsilon 4 (APOE*4) to familial and sporadic late-onset Alzheimer's disease (LOAD).

  32. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1994-05-01 Genetics

    Apolipoprotein E4 (apoE4), one of the three common isoforms of apoE, has been implicated in Alzheimer's disease.

  33. Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The Journal of biological chemistry 1994-05-01 Risk genes beyond APOE

    We have investigated the possible effect of estrogen on the metabolism of the Alzheimer amyloid precursor protein (APP).

  34. Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 1994-05-01 Risk genes beyond APOE

    Abnormal metabolic processing of the beta/A4 amyloid precursor protein (APP) has been implicated in the pathogenesis of Alzheimer disease.

  35. Soluble amyloid beta-protein is a marker of Alzheimer amyloid in brain but not in cerebrospinal fluid

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Biochemical and biophysical research communications 1994-05-01 Risk genes beyond APOE

    The amyloid beta protein (A beta), a 4 kD fragment of the beta amyloid precursor protein, is deposited as insoluble amyloid in the brain of Alzheimer disease (AD) subjects.

  36. Apolipoprotein E: risk factor for Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. American journal of human genetics 1994-04-01 Genetics

    The apolipoprotein E gene (APOE) has three common alleles (epsilon 2, epsilon 3, and epsilon 4) that determine six genotypes in the general population.

  37. Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Journal of neurology, neurosurgery, and psychiatry 1994-04-01 Risk genes beyond APOE

    In a recent preliminary study it was reported that a severe head injury resulted in the deposition of beta amyloid protein (beta AP) in the cortical ribbon of 30% of patients who survived for less than two weeks.

  38. Chemical characterization of A beta 17-42 peptide, a component of diffuse amyloid deposits of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The Journal of biological chemistry 1994-04-01 Risk genes beyond APOE

    A peptide corresponding to the amino acid sequence of A beta 17-42 (LVFFAEDVGSNKGAIIGLMVGGVVIA) was isolated from Alzheimer Disease patient brains containing large deposits of diffuse-type amyloid.

  39. Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The EMBO journal 1994-03-01 Risk genes beyond APOE

    Accumulation of the amyloid A beta peptide, which is derived from a larger precursor protein (APP), and the formation of plaques, are major events believed to be involved in the etiology of Alzheimer's disease.

  40. Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II)

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of neurochemistry 1994-03-01 Brain tissue and pathology

    Major membrane lipids were quantified in frontal (Brodmann area 9) and temporal (Brodmann areas 21 and 22) cortices, caudate nucleus, hippocampus, and frontal white matter of 12 cases with Alzheimer's disease (AD) type I (early onset), 21 cases with AD type II (late onset), and 20 age-matched controls.

  41. Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Experimental neurology 1994-02-01 Brain tissue and pathology

    A genetic classification of Alzheimer disease(s) (AD) is presented.

  42. Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Human Molecular Genetics 1994-01-01 Genetics

    An association between the 19q13.2 chromosomal region and Alzheimer's disease (AD) has been reported in AD families and for sporadic AD.

  43. apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1993-12-01 Risk genes beyond APOE

    The major component of senile plaques found in the brains of Alzheimer disease patients is the beta-amyloid peptide, which is derived from a larger amyloid precursor protein (APP).

  44. pH-dependent binding of synthetic beta-amyloid peptides to glycosaminoglycans

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neurochemistry 1993-12-01 Risk genes beyond APOE

    The senile plaques found within the cerebral cortex and hippocampus of the Alzheimer disease brain contain beta-amyloid peptide (A beta) fibrils that are associated with a variety of macromolecular species, including dermatan sulfate proteoglycan and heparan sulfate proteoglycan.

  45. Early and rapid de novo synthesis of Alzheimer beta A4-amyloid precursor protein (APP) in activated microglia

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Glia 1993-11-01 Risk genes beyond APOE

    Upon acute activation, microglia, the immuneffector cells of the brain parenchyma, express the amyloid precursor protein (APP) that is otherwise prominent in pathological structures related to Alzheimer's disease.

  46. Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1993-11-01 Risk genes beyond APOE

    We have recently shown that the Alzheimer disease 40-residue amyloid beta-protein [A beta P-(1-40)] can form cation-selective channels when incorporated into planar lipid bilayers by fusion of liposomes containing the peptide.

  47. Morphological and biochemical analyses of amyloid plaque core proteins purified from Alzheimer disease brain tissue

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neurochemistry 1993-11-01 Risk genes beyond APOE

    Amyloid plaque cores were purified from Alzheimer disease brain tissue.

  48. The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Annals of neurology 1993-11-01 Disparities

    Apolipoprotein E (APO-E) binds to the beta-amyloid peptide and is present in senile neuritic plaques in Alzheimer's disease (AD).

  49. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neuron 1993-10-01 Genetics

  50. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1993-10-01 Genetics

    Amyloid beta-peptide (A beta) deposition in senile plaques and cerebral vessels is a neuropathological feature of Alzheimer disease (AD).

From across this tag

9 of the 1,611 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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