alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Home › Research › Topics › apolipoprotein

apolipoprotein

1,613 studies tagged apolipoprotein, dated 1982-09-01 to 2026-10-27. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. ApoE4 and Psychosis in Neurodegenerative and Non-Neurodegenerative Disease: A Scoping Review 2026-10-27
  2. Multimodal mediators connecting APOE4 to dementia 2026-10-21
  3. Reproductive Aging, FSH, and Apolipoprotein Biology in Alzheimer’s Disease 2026-10-19

Studies

1,613 studies carry this tag.

Date range

1982 to 2026

Top journals

  • Neurology 93
  • The Journal of biological chemistry 68
  • Proceedings of the National Academy of Sciences of the United States of America 52
  • Archives of neurology 43
  • Neurobiology of aging 38

457 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. ABCA1 Is Required for Normal Central Nervous System ApoE Levels and for Lipidation of Astrocyte-secreted apoE

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 2004-07-21 Genetics

    ABCA1 is an ATP-binding cassette protein that transports cellular cholesterol and phospholipids onto high density lipoproteins (HDL) in plasma.

  2. Analysis of European mitochondrial haplogroups with Alzheimer disease risk

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Neuroscience letters 2004-07-01 Genetics

    We examined the association of mtDNA variation with Alzheimer disease (AD) risk in Caucasians (989 cases and 328 controls) testing the effect of individual haplogroups and single nucleotide polymorphisms (SNPs).

  3. Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Experimental neurology 2004-07-01 Genetics

    We compared lesions in elderly transgenic (tg) mice carrying the Swedish double mutation KM670/671NL with lesions in Alzheimer disease (AD) by histochemical and immunohistochemical techniques.

  4. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Nature medicine 2004-06-13 Genetics

    We have previously shown that apolipoprotein E (Apoe) promotes the formation of amyloid in brain and that astrocyte-specific expression of APOE markedly affects the deposition of amyloid-beta peptides (Abeta) in a mouse model of Alzheimer disease.

  5. APOE-[epsilon]2 allele associated with higher prevalence of sporadic Parkinson disease

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurology 2004-06-01 Genetics

    Unlike Alzheimer disease, for which the APOE-epsilon4 allele increases the prevalence and the APOE-epsilon2 allele is protective, the authors' analysis shows the APOE-epsilon2 allele, but not the APOE-epsilon4 allele, to be positively associated with sporadic Parkinson disease.

  6. APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurology 2004-06-01 Genetics

    The epsilon4 allele of APOE is a risk factor for Alzheimer disease (AD).

  7. Apolipoprotein E controls the risk and age at onset of Parkinson disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neurology 2004-06-01 Genetics

    The APOE-4 allele increases risk and decreases age at onset of PD, an association that may not be dependent upon cognitive impairment.

  8. Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurology 2004-06-01 Genetics

    The epsilon4 allele does not predict cholinergic decline in AD.

  9. Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Neurology 2004-06-01 Genetics

    Memory declined in APOE e4 carriers before the symptomatic presentation of MCI in a cohort whose mean age was 60 years over a median period of 33 months.

  10. Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Dalton transactions (Cambridge, England : 2003) 2004-05-11 Risk genes beyond APOE

    A change of the prion protein conformation results in a class of neurodegenerative diseases called the transmissible spongiform encephalopathies (like mad cow and Creutzfeld-Jakob diseases).

  11. A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Annals of neurology 2004-05-01 Disease mechanisms

    Familial forms of frontotemporal dementia (FTD) with tauopathy are mostly caused by mutations in the gene encoding the microtubule-associated protein tau (MAPT).

  12. Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neuropathology and experimental neurology 2004-05-01 Risk genes beyond APOE

    In Alzheimer disease (AD) patients, early memory dysfunction is associated with glucose hypometabolism and neuronal loss in the hippocampus.

  13. Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of peptide science : an official publication of the European Peptide Society 2004-05-01 Risk genes beyond APOE

    The extracellular accumulation of amyloid-beta (Abeta) in neuritic plaques is one of the characteristic hallmarks of Alzheimer's disease (AD), a progressive dementing neurodegenerative disorder of the elderly.

  14. Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Archives of general psychiatry 2004-05-01 Genetics

    The APOE epsilon4 allele acts as a potent risk factor for AD by accelerating onset.

  15. Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Neurobiology of aging 2004-05-01 Biomarkers

    Amyloid plaques appear early during Alzheimer's disease (AD), and their development is intimately linked to activated astrocytes and microglia.

  16. Dendrite and dendritic spine alterations in Alzheimer models

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neurocytology 2004-05-01 Risk genes beyond APOE

    Synaptic damage and loss are factors that affect the degree of dementia experienced in Alzheimer disease (AD) patients.

  17. The microglial phagocytic role with specific plaque types in the Alzheimer disease brain

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurobiology of aging 2004-05-01 Inflammation and the immune system

    Alzheimer disease (AD) involves glial inflammation associated with amyloid plaques.

  18. Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2004-04-01 Risk genes beyond APOE

    Beta-amyloid peptides that are cleaved from the amyloid precursor protein (APP) play a critical role in Alzheimer's disease (AD) pathophysiology.

  19. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. European journal of pharmacology 2004-04-01 Risk genes beyond APOE

    Nosologically, Alzheimer disease is not a single disorder in spite of a common clinical phenotype.

  20. Androgens, apoE, and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Science of aging knowledge environment : SAGE KE 2004-03-17 Genetics

    Increasing evidence indicates that there are reductions in estrogen and androgen levels in aged men and women.

  21. Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neurology 2004-03-01 Biomarkers

    These data support distinct processes in the initiation and progression of AD pathology within the temporal cortex: Deposition of Abeta reaches a "ceiling" early in the disease process, whereas NFT formation, synaptic loss, and gliosis continue throughout the course of the illness.

  22. Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Archives of neurology 2004-03-01 How common it is

    Longitudinal clinicopathologic cohort study.

  23. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2004-03-01 Biomarkers

    Apolipoprotein E (apoE) is found in amyloid plaques and neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) brains, but its role in their pathogenesis is unclear.

  24. Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Archives of neurology 2004-03-01 Treatments

    This study questions the effect of statins on the processing of amyloid precursor protein in humans.

  25. Brain cholesterol: long secret life behind a barrier

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Arteriosclerosis, thrombosis, and vascular biology 2004-02-05 Risk factors

    Although an immense knowledge has accumulated concerning regulation of cholesterol homeostasis in the body, this does not include the brain, where details are just emerging.

  26. Binding sites of amyloid beta-peptide in cell plasma membrane and implications for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Current protein & peptide science 2004-02-01 Risk genes beyond APOE

    The binding of amyloid beta peptides (Abeta) to plasma membranes appears to be a promising point of intervention in the events leading to the development of Alzheimer's disease (AD).

  27. Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Neurology 2004-02-01 Risk genes beyond APOE

    Amyloid precursor protein (APP), ADAM 10, and beta-site-APP cleaving enzyme (BACE) alterations were evaluated in platelets of 31 patients with Alzheimer disease (AD) and 15 age-matched controls.

  28. A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of molecular neuroscience : MN 2004 Genetics

    Chronically activated glia associated with amyloid plaques might contribute to neuronal dysfunction in Alzheimer's disease (AD) through generation of neuroinflammatory molecules.

  29. Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Advances in experimental medicine and biology 2004-01-01 Risk genes beyond APOE

    Alzheimer disease is not a single disorder.

  30. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neuron 2003-12-01 Risk genes beyond APOE

    Converging evidence suggests that the accumulation of cerebral amyloid beta-protein (Abeta) in Alzheimer's disease (AD) reflects an imbalance between the production and degradation of this self-aggregating peptide.

  31. Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neuropathology and experimental neurology 2003-12-01 Risk genes beyond APOE

    Epidemiological studies of Alzheimer patients from a wide variety of ethnic and socioeconomic backgrounds have identified education and occupation as environmental factors that can affect the risk of developing disease.

  32. Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cancer research 2003-11-01 Risk genes beyond APOE

    Abnormal cleavage of amyloid precursor protein (APP) in the central nervous system has been linked to the development of Alzheimer's disease.

  33. A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Brain pathology (Zurich, Switzerland) 2003-10-01 Risk genes beyond APOE

    Immunostaining of adenosine receptors in the hippocampus and cerebral cortex from necropsies of Alzheimer disease (AD) patients shows that there is a change in the pattern of expression and a redistribution of receptors in these brain areas when compared with samples from controls.

  34. Circle of willis atherosclerosis is a risk factor for sporadic Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Arteriosclerosis, thrombosis, and vascular biology 2003-09-25 Risk factors

    We conducted a quantitative investigation of brain arterial atherosclerotic damage and its relationship to sporadic Alzheimer's disease (AD).

  35. Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neurological research 2003-09-01 Risk genes beyond APOE

    Cerebral amyloid angiopathy (CAA) is a feature of ageing and Alzheimer's disease (AD); it is also associated with intracerebral hemorrhage and stroke.

  36. Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Experimental neurology 2003-09-01 Genetics

    One of the major histopathological hallmarks of Alzheimer's disease (AD) is redundant senile plaques mainly composed of beta-amyloid (Abeta) aggregates.

  37. Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular psychiatry 2003-09-01 Biomarkers

    Glial fibrillary acidic protein (GFAP) is considered to be a highly specific marker for glia.

  38. DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2003-07-01 Risk genes beyond APOE

    Apoptotic pathways and DNA synthesis are activated in neurons in the brains of individuals with Alzheimer disease (AD).

  39. Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurology 2003-07-01 Genetics

    Serum hypercholesterolemia may be an early risk factor for the development of AD amyloid pathology.

  40. Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Neuron 2003-07-01 Laboratory science

    Researchers derived a triple-transgenic model to study the interaction between Abeta and tau and their effect on synaptic function.

  41. Genetics of early-onset Alzheimer dementia

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. TheScientificWorldJournal 2003-06-16 Risk genes beyond APOE

    Alzheimer's dementia (AD) is the most common degenerative disorder of the central nervous system.

  42. Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Archives of neurology 2003-06-01 Genetics

    Inheritance of the APOE epsilon4 allele is associated with increased risk of late posttraumatic seizures.

  43. Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of neurochemistry 2003-06-01 Risk genes beyond APOE

    Vaccination against human beta-amyloid peptide (A beta) has been shown to remove the amyloid burden produced in transgenic mice overexpressing the mutated human amyloid precursor protein (APP) gene.

  44. Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain research 2003-05-01 Down syndrome and Alzheimer's

    beta-Amyloid(1-42) (A beta 42), a major component of amyloid plaques, accumulates within pyramidal neurons in the brains of individuals with Alzheimer's disease (AD) and Down syndrome.

  45. Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Archives of internal medicine 2003-05-01 Genetics

    In this large, population-based cohort, baseline and long-term average serum total cholesterol levels were not associated with the risk for incident AD.

  46. Alzheimer's disease: the cholesterol connection

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature neuroscience 2003-04-01 Genetics

    A hallmark of all forms of Alzheimer's disease (AD) is an abnormal accumulation of the beta-amyloid protein (Abeta) in specific brain regions.

  47. Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. The British journal of nutrition 2003-04-01 Cognitive tests and assessment

    Low n-3 polyunsaturated fatty acid (PUFA) status may be associated with neuro-degenerative disorders, in particular Alzheimer's disease, which has been associated with poor dietary fish or n-3 PUFA intake, and low docosahexaenoic acid (DHA) status.

  48. Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. FEBS letters 2003-04-01 Risk genes beyond APOE

    Presenilin 1 (PS1) is a key factor for beta-amyloid (Ab) formation in Alzheimer disease (AD).

  49. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Nature medicine 2003-03-17 Brain tissue and pathology

    Amyloid-beta peptide (Abeta) has a key role in the pathogenesis of Alzheimer disease (AD).

  50. Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Archives of neurology 2003-02-01 Genetics

    Apolipoprotein E epsilon4 led to increased risk of AD among white subjects but not black subjects.

From across this tag

10 of the 1,611 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts