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Home › Research › Topics › apolipoprotein

apolipoprotein

1,613 studies tagged apolipoprotein, dated 1982-09-01 to 2026-10-27. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. ApoE4 and Psychosis in Neurodegenerative and Non-Neurodegenerative Disease: A Scoping Review 2026-10-27
  2. Multimodal mediators connecting APOE4 to dementia 2026-10-21
  3. Reproductive Aging, FSH, and Apolipoprotein Biology in Alzheimer’s Disease 2026-10-19

Studies

1,613 studies carry this tag.

Date range

1982 to 2026

Top journals

  • Neurology 93
  • The Journal of biological chemistry 68
  • Proceedings of the National Academy of Sciences of the United States of America 52
  • Archives of neurology 43
  • Neurobiology of aging 38

457 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Apolipoprotein E polymorphism and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Lancet (London, England) 1993-09-01 Genetics

    Apolipoprotein E (apoE) is associated with Alzheimer's neurofibrillary tangles and beta-amyloid protein in senile plaques.

  2. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1993-09-01 Genetics

    Apolipoprotein E (apoE), a plasma apolipoprotein that plays a central role in lipoprotein metabolism, is localized in the senile plaques, congophilic angiopathy, and neurofibrillary tangles of Alzheimer disease.

  3. Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Science 1993-08-13 Genetics

    The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD).

  4. Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. Neurology 1993-08-01 Genetics

    Apolipoprotein E, type epsilon 4 allele (APOE epsilon 4), is associated with late-onset familial Alzheimer's disease (AD).

  5. Alpha 1-antichymotrypsin binding to Alzheimer A beta peptides is sequence specific and induces fibril disaggregation in vitro

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of neurochemistry 1993-07-01 Risk genes beyond APOE

    The serine protease inhibitor alpha 1-antichymotrypsin (ACT) consistently colocalizes with amyloid deposits of Alzheimer's disease (AD) and may contribute to the generation of amyloid proteins and/or physically affect fibril assembly.

  6. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1993-04-01 Risk genes beyond APOE

    Calcium-activated neutral proteinases (CANPs or calpains) are believed to be key enzymes in intracellular signaling cascades and potential mediators of calcium-induced neuronal degeneration.

  7. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1993-03-01 Genetics

    Apolipoprotein E is immunochemically localized to the senile plaques, vascular amyloid, and neurofibrillary tangles of Alzheimer disease.

  8. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1993-03-01 Risk genes beyond APOE

    The cellular mechanism underlying the generation of beta-amyloid in Alzheimer disease and its relationship to the normal metabolism of the amyloid precursor protein are unknown.

  9. Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. The Journal of biological chemistry 1993-01-01 Risk genes beyond APOE

    The Alzheimer beta/A4 amyloid precursor protein (APP) can be proteolytically processed by at least two separate pathways in PC12 cells: chloroquine-insensitive secretory cleavage and chloroquine-sensitive intracellular degradation, presumably in the endosomal/lysosomal system.

  10. MHC class II-positive microglia in human brain: association with Alzheimer lesions

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neuroscience research 1992-12-01 Inflammation and the immune system

    Cells of the mononuclear phagocytic system (MPS) present foreign antigen on their cell surfaces bound to major histocompatibility complex (MHC) class II molecules.

  11. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Nature 1992-12-01 Risk genes beyond APOE

  12. Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1992-11-01 Risk genes beyond APOE

    The deposition of amyloid in senile plaques and along the walls of the cerebral vasculature is a characteristic feature of Alzheimer disease.

  13. Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. American journal of human genetics 1992-11-01 Risk genes beyond APOE

    A large number of familial Alzheimer disease (FAD) kindreds were examined to determine whether mutations in the amyloid precursor protein (APP) gene could be responsible for the disease.

  14. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1992-10-01 Risk genes beyond APOE

    Despite increasing evidence for a pathogenetic role for the beta-amyloid precursor protein (beta APP) in Alzheimer disease, the physiological function of the protein remains unclear.

  15. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Science (New York, N.Y.) 1992-10-01 Risk genes beyond APOE

    Altered processing of the amyloid precursor protein (APP) is a central event in the formation of amyloid deposits in the brains of individuals with Alzheimer's disease.

  16. Amyloid β-peptide is produced by cultured cells during normal metabolism

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Nature 1992-09-01 Disease mechanisms

  17. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Nature Genetics 1992-08-01 Risk genes beyond APOE

  18. Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1992-08-01 Risk genes beyond APOE

    The A4 or beta protein is a peptide that constitutes the major protein component of senile plaques in Alzheimer disease.

  19. Beta-amyloid precursor protein cleavage by a membrane-bound protease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1992-07-01 Risk genes beyond APOE

    The principal component of amyloid plaques in Alzheimer disease is beta-amyloid protein, an approximately 4-kDa peptide derived from amyloid precursor proteins.

  20. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Nature genetics 1992-06-01 Brain tissue and pathology

    Several families with an early-onset form of familial Alzheimer's disease have been found to harbour mutations at a specific codon (717) of the gene for the beta-amyloid precursor protein (APP) on chromosome 21.

  21. Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1992-04-01 Risk genes beyond APOE

    Extracellular deposition of the beta/A4 amyloid peptide is a characteristic feature of the brain in patients with Alzheimer disease. beta/A4 amyloid is derived from the amyloid precursor protein (APP), an integral membrane protein that exists as three major isoforms (APP695, APP751, and APP770).

  22. The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer disease and associated disorders 1992-01-01 Risk genes beyond APOE

    New molecular information about Alzheimer disease (AD) is appearing at an unprecedented rate.

  23. Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1991-12-01 Risk genes beyond APOE

    beta-Amyloid formation requires multiple abnormal proteolytic cleavages of amyloid precursor protein (APP), including one within its intramembrane domain.

  24. Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Brain research 1991-11-01 Risk genes beyond APOE

    We have recently shown that the amyloid beta A4 precursor protein (APP) is synthesized in neurons and undergoes fast axonal transport to synaptic sites [Koo et al., Proc.

  25. The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1991-11-01 Down syndrome and Alzheimer's

    The amyloid beta protein and the amyloid beta-protein precursor (APP) are major constituents of senile plaques and cerebrovascular deposits in patients with Alzheimer disease and Down syndrome.

  26. Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Annals of Neurology 1991-10-01 Brain tissue and pathology

    We present here both linear regressions and multivariate analyses correlating three global neuropsychological tests with a number of structural and neurochemical measurements performed on a prospective series of 15 patients with Alzheimer's disease and 9 neuropathologically normal subjects.

  27. APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. American journal of human genetics 1991-09-01 Down syndrome and Alzheimer's

    The amyloid precursor protein (APP) gene codes for the precursor to the beta-protein found in the amyloid deposits of Alzheimer disease (AD).

  28. Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1991-09-01 Risk genes beyond APOE

    Senile plaques are polymorphous beta-amyloid protein deposits found in the brain in Alzheimer disease and normal aging.

  29. Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. American journal of human genetics 1991-06-01 Brain tissue and pathology

    A genetic component in the etiology of Alzheimer disease (AD) has been supported by indirect evidence for several years, with autosomal dominant inheritance with age-dependent penetrance being suggested to explain the familial aggregation of affecteds.

  30. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Nature 1991-02-21 Genetics

    To avoid the problems that heterogeneity poses for genetic analysis, the researchers examined the cosegregation of Alzheimer's disease and markers along the long arm of chromosome 21 in a single family.

  31. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain Research 1991-02-01 Brain tissue and pathology

    Researchers conducted immunohistochemical studies on lipid changes in Alzheimer's disease brains using an antibody to apolipoprotein E. They unexpectedly discovered that apo E immunoreactivity was associated with amyloid in senile plaques, cerebral vessels, and neurofibrillary tangles, as well as in kuru plaques in Creutzfeldt-Jakob disease.

  32. The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Brain research. Molecular brain research 1991-02-01 Down syndrome and Alzheimer's

    Transcriptional regulation of the gene encoding the amyloid precursor protein (APP) may play an important role in the formation of the amyloid depositions observed in Alzheimer disease and Down syndrome patients.

  33. Measurement of amyloid peptide precursor of Alzheimer disease in human blood by double antibody immunoradiometric assay

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Alzheimer disease and associated disorders 1991-01-01 Down syndrome and Alzheimer's

    The dementia of Alzheimer disease (AD) correlates with the deposition of extracellular amyloid, and this amyloid arises from the abnormal processing of a high molecular weight amyloid peptide precursor (APP), which is a normal cellular protein that is found in both brain and in peripheral tissues in humans.

  34. Glial fibrillary acidic protein and beta A4 protein deposits in temporal lobe of aging brain and senile dementia of the Alzheimer type: relation with the cognitive state and with quantitative studies of senile plaques and neurofibrillary tangles

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neuroscience research 1990-12-01 Biomarkers

    The aim of this study was to compare brain glial fibrillary acidic protein (GFAP) levels to the modifications of cognitive functions (Blessed test score [BTS]), the density of the main neuropathological lesions (senile plaques [SP] and neurofibrillary tangles [NFT]), and the density of the two main subtypes of beta A4 deposits (classic plaques and diffuse deposits) in a series of patients with normal aging and senile dementia of the Alzheimer type of various degrees of severity.

  35. Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neuroscience letters 1990-10-01 Inflammation and the immune system

    Alzheimer senile plaques are comprised of extracellular deposits of beta-amyloid.

  36. The amyloid precursor protein of Alzheimer's disease is released by human platelets

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The Journal of biological chemistry 1990-09-01 Risk genes beyond APOE

    Western blots of normal human platelets, employing a monoclonal antibody raised against the full-length amyloid precursor protein of Alzheimer's disease (APP695), revealed major bands of 100-110 and 120-130 kDa in both cytosolic, membrane, and released fractions.

  37. Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1990-08-01 Risk genes beyond APOE

    The turnover and processing of the Alzheimer beta/A4 amyloid precursor protein (beta APP) has been studied in PC12 cells after treatment with agents that regulate protein phosphorylation.

  38. Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research 1990-07-01 Inflammation and the immune system

    Expression of major histocompatibility complex (MHC) class I (HLA-A,B,C) and class II (HLA-DR) antigens was studied in postmortem brain tissue of Alzheimer's disease and age-matched control cases.

  39. Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Science 1990-06-01 Risk genes beyond APOE

    An amyloid protein that precipitates in the cerebral vessel walls of Dutch patients with hereditary cerebral hemorrhage with amyloidosis is similar to the amyloid protein in vessel walls and senile plaques in brains of patients with Alzheimer's disease, Down syndrome, and sporadic cerebral amyloid angiopathy.

  40. Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Science (New York, N.Y.) 1990-06-01 Risk genes beyond APOE

    An inhibitor of coagulation factor XIa was purified from serum-free conditioned medium of HepG2 liver cells.

  41. Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1990-05-01 Risk genes beyond APOE

    The formation of beta-amyloid in the brains of individuals with Alzheimer disease requires the proteolytic cleavage of a membrane-associated precursor protein.

  42. Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain research 1990-04-01 Risk genes beyond APOE

    To investigate the role of proteolysis in amyloid formation, we studied the localization of the proteolytic enzymes, cathepsin D and cathepsin B, in the prefrontal cerebral cortex and hippocampus of human postmortem brains from patients with Alzheimer's disease and from individuals free of neurological disease.

  43. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Journal of Lipid Research 1990-03-01 Genetics

    We have used restriction isotyping (restriction enzyme isoform genotyping) for rapid typing of common apolipoprotein E isoforms (E2, E3, E4).

  44. The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. The Journal of biological chemistry 1990-03-01 Risk genes beyond APOE

    The amyloid forming beta-peptide of Alzheimer's disease is synthesized as part of a larger integral membrane precursor protein (beta APP) of which three alternatively spliced versions of 695, 751, and 770 amino acids have been described.

  45. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1990-02-01 Risk genes beyond APOE

    In the brains of aged humans and cases of Alzheimer disease, deposits of amyloid in senile plaques are located in proximity to nerve processes.

  46. Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Acta neuropathologica 1990-01-01 Inflammation and the immune system

    A strong immunoreactivity for ferritin was observed in the neuritic (senile) plaques in Alzheimer's disease hippocampus.

  47. The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Experimental neurology 1989-12-01 Risk genes beyond APOE

    The 4.2-kilodalton (kDa) polypeptide associated with the cerebral amyloid deposits of Alzheimer's disease (AD) derives from a much larger protein that is encoded by a gene on chromosome 21.

  48. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Journal of neuroimmunology 1989-10-01 Inflammation and the immune system

    The relationship of microglia and astrocytes to deposits of beta-amyloid protein (BAP) was studied in Alzheimer's disease by immunohistochemistry.

  49. Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience letters 1989-08-01 Disease mechanisms

    Alzheimer disease (AD) as well as other dementing disorders are characterized by a continuous loss of neurons in cortical and subcortical areas and probably by an extensive synaptic loss.

  50. Altered expression of genes for amyloid and cytoskeletal proteins in Alzheimer cortex

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Annals of neurology 1989-04-01 Biomarkers

    Recent studies have indicated a normal gene dose for the amyloid precursor protein (APP) in Alzheimer's disease (AD).

From across this tag

9 of the 1,611 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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