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61/100

✓ Peer-reviewed alzhub usefulness score 61 out of 100. Cognitive tests and assessment

Topic: Risk, prevention and care in population studies

Background Delirium is a profound neuropsychiatric disturbance precipitated by acute illness. Although dementia is the major risk factor this has typically been considered a binary quantity (i.e., cognitively impaired versus cognitively normal) with respect to delirium risk. We used humans and mice to address the hypothesis that the severity of underlying neurodegenerative changes and/or cognitive impairment progressively alters delirium risk.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Davis, D. H. J., Skelly, D. T., Murray, C., Hennessy, E., Bowen, J., Norton, S., et al. (2015). Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. https://doi.org/10.1016/j.jagp.2014.08.005

Vancouver

Davis DHJ, Skelly DT, Murray C, Hennessy E, Bowen J, Norton S, et al. Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2015. doi:10.1016/j.jagp.2014.08.005. PMID: 25239680.

BibTeX

@article{davis2015-25239680,
  author  = {Davis, D. H. J. and Skelly, D. T. and Murray, C. and Hennessy, E. and Bowen, J. and Norton, S. and Brayne, C. and Rahkonen, T. and others},
  title   = {{Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2015},
  doi     = {10.1016/j.jagp.2014.08.005},
  pmid    = {25239680},
  url     = {https://doi.org/10.1016/j.jagp.2014.08.005}
}

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Key findings

Although dementia is the major risk factor this has typically been considered a binary quantity (i.e., cognitively impaired versus cognitively normal) with respect to delirium risk.
We used humans and mice to address the hypothesis that the severity of underlying neurodegenerative changes and/or cognitive impairment progressively alters delirium risk.
Methods Humans in a population-based longitudinal study, Vantaa 85+, were followed for incident delirium.
Odds for reporting delirium at follow-up (outcome) were modeled using random-effects logistic regression, where prior cognitive impairment measured by Mini-Mental State Exam (MMSE) (exposure) was considered.

Why it matters

Delirium risk in people with dementia has usually been treated as yes-or-no: cognitively impaired or not. This study asked whether risk instead rises step by step as cognitive impairment and brain changes worsen. It followed people in the population-based Vantaa 85+ study for new delirium, measured earlier impairment with the MMSE, and also used mice. It is an observational look at delirium risk, not a test of any treatment for Alzheimer's disease.

Study details

Study designlongitudinal study
Participants465
Effect sizeincreased by 5%
Evidence strengthModerate

How this study scored 61/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry)
Journal's citation record	2 / 4	American Journal of Geriatric Psychiatry: journal h-index 178 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2015 — within 20 year(s) of the newest study here
Sample size	2 / 4	465 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 139 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	10.7 citations a year over 13 year(s) since 2015
Impact for its field and year	3 / 6	Cited 7.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 8 other studies in this library
Still being cited	2 / 4	Cited 31 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Colm M. Cunningham: h-index 64 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Oxford: institution h-index 2,205 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 8 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 25239680)
Free to read	0 / 2	Behind a paywall — scores zero
Total	61 / 100	—

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