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Using amyloid PET imaging to diagnose Alzheimer's disease in patients with multiple sclerosis
Magdalena Kolanko, Zarni Win, Neva Patel, Omar Malik, Christopher Carswell, Anastassia Gontsarova, Richard Nicholas, Richard Perry et al.. Journal of neurology, 2020-06-18
Topic: Plasma and spinal-fluid biomarkers
Two patients were diagnosed with AD based on positive Amyloid PET imaging and were subsequently started on cholinesterase inhibitor treatment. The other patient had a negative scan, leading to further investigations and identification of another potential cause of worsening cognitive impairment. The experience from this case series suggests that Amyloid PET Imaging may be of diagnostic value in selected patients with MS and dementia. In these individuals, it may provide diagnostic clarity and assist with therapeutic decisions.
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APA 7th
Kolanko, M., Win, Z., Patel, N., Malik, O., Carswell, C., Gontsarova, A., et al. (2020). Using amyloid PET imaging to diagnose Alzheimer's disease in patients with multiple sclerosis. Journal of neurology. https://doi.org/10.1007/s00415-020-09969-z
Vancouver
Kolanko M, Win Z, Patel N, Malik O, Carswell C, Gontsarova A, et al. Using amyloid PET imaging to diagnose Alzheimer's disease in patients with multiple sclerosis. Journal of neurology. 2020. doi:10.1007/s00415-020-09969-z. PMID: 32556533.
BibTeX
@article{kolanko2020-32556533,
author = {Kolanko, Magdalena and Win, Zarni and Patel, Neva and Malik, Omar and Carswell, Christopher and Gontsarova, Anastassia and Nicholas, Richard and Perry, Richard and others},
title = {{Using amyloid PET imaging to diagnose Alzheimer's disease in patients with multiple sclerosis}},
journal = {Journal of neurology},
year = {2020},
doi = {10.1007/s00415-020-09969-z},
pmid = {32556533},
url = {https://doi.org/10.1007/s00415-020-09969-z}
}
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Key findings
- Two patients were diagnosed with AD based on positive Amyloid PET imaging and were subsequently started on cholinesterase inhibitor treatment.
- The other patient had a negative scan, leading to further investigations and identification of another potential cause of worsening cognitive impairment.
- The experience from this case series suggests that Amyloid PET Imaging may be of diagnostic value in selected patients with MS and dementia.
- In these individuals, it may provide diagnostic clarity and assist with therapeutic decisions.
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Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32556533) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 22 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
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