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Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease
Christina Tremblay, Shady Rahayel, Alexandre Pastor‐Bernier, Frédéric St‐Onge, Andrew N. Vo, François Rheault, Véronique Daneault, Filip Morys et al.. Brain Communications, 2025-01-01
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease is associated with pre-symptomatic changes in brain morphometry and accumulation of abnormal tau and amyloid-beta pathology. Cross-sectional and longitudinal data up to 4 years were used to perform atrophy progression analysis in FHAD and Alzheimer's disease compared with controls. Our results show that there were similar patterns of atrophy progression in FHAD and Alzheimer's disease, notably in the cingulate, temporal and parietal cortices, with more widespread and severe atrophy in Alzheimer's disease. In Alzheimer's disease, our findings suggest that atrophy progression results from pathology propagation that occurred earlier, on a previously intact connectome.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Tremblay, C., Rahayel, S., Pastor‐Bernier, A., St‐Onge, F., Vo, A. N., Rheault, F., et al. (2025). Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease. Brain Communications. https://doi.org/10.1093/braincomms/fcaf099
Vancouver
Tremblay C, Rahayel S, Pastor‐Bernier A, St‐Onge F, Vo AN, Rheault F, et al. Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease. Brain Communications. 2025. doi:10.1093/braincomms/fcaf099. PMID: 40092368.
BibTeX
@article{tremblay2025-40092368,
author = {Tremblay, Christina and Rahayel, Shady and Pastor‐Bernier, Alexandre and St‐Onge, Frédéric and Vo, Andrew N. and Rheault, François and Daneault, Véronique and Morys, Filip and others},
title = {{Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease}},
journal = {Brain Communications},
year = {2025},
doi = {10.1093/braincomms/fcaf099},
pmid = {40092368},
url = {https://doi.org/10.1093/braincomms/fcaf099}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Alzheimer's disease is associated with pre-symptomatic changes in brain morphometry and accumulation of abnormal tau and amyloid-beta pathology.
- Cross-sectional and longitudinal data up to 4 years were used to perform atrophy progression analysis in FHAD and Alzheimer's disease compared with controls.
- Our results show that there were similar patterns of atrophy progression in FHAD and Alzheimer's disease, notably in the cingulate, temporal and parietal cortices, with more widespread and severe atrophy in Alzheimer's disease.
- In Alzheimer's disease, our findings suggest that atrophy progression results from pathology propagation that occurred earlier, on a previously intact connectome.
Why it matters
Using cross-sectional and longitudinal data up to 4 years, this study found similar patterns of brain atrophy progression in people at familial risk of Alzheimer's disease and in Alzheimer's disease itself, with more widespread and severe atrophy in Alzheimer's disease. It describes how atrophy progresses and does not test any treatment, cure or prevention.
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Study details
- Study designcross-sectional
- Evidence strengthModerate
How this study scored 46/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain Communications) |
| Journal's citation record | 0 / 4 | Brain Communications: journal h-index 67 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 5 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 3.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Les M. Shaw: h-index 32 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | McGill University: institution h-index 1,373 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40092368) |
| Free to read | 2 / 2 | Free to read |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1093/braincomms/fcaf099
- PubMed: 40092368
- Original source →
- Free full text: Brain Communications →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Studies this one cites
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