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Vps35-dependent recycling of Trem2 regulates microglial function
Yin J, Liu X, He Q, Zhou L, Yuan Z, Zhao S.. Traffic (Copenhagen, Denmark), 2016-11-01
Topic: Brain proteins, microglia and lab models
Triggering receptor expressed on myeloid cells 2 (Trem2), an immune-modulatory receptor, is preferentially expressed in microglia of central nervous system. Trem2 might be involved in the development of Alzheimer's disease (AD) through regulating the inflammatory responses and phagocytosis of microglia. However, the intracellular trafficking of Trem2 remains unclear.
Key findings
- Trem2 might be involved in the development of Alzheimer's disease (AD) through regulating the inflammatory responses and phagocytosis of microglia.
- However, the intracellular trafficking of Trem2 remains unclear.
- In this study, we showed that Trem2 in the plasma membrane underwent endocytosis and recycling.
- Trem2 is internalized in a clathrin-dependent manner and then recycled back to the plasma membrane through vacuolar protein sorting 35 (Vps35), the key component of cargo recognition core of retromer complex, but not Rab11.
Why it matters
Trem2 is a receptor found mainly on microglia, the brain's immune cells, and is thought to possibly influence Alzheimer's disease through inflammation and the clearing of debris. This study found that Trem2 is pulled into the cell by a clathrin-dependent process and returned to the surface by Vps35, part of the retromer complex, and not by the Rab11 route. It is a study of how one receptor moves within cells; it does not test Alzheimer's outcomes or any treatment.
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Study details
- Evidence strengthLow
How this study scored 42/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Traffic (Copenhagen, Denmark)) |
| Journal's citation record | 2 / 4 | Traffic: journal h-index 174 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 90 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.5 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 3 / 6 | Cited 4.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 2 / 4 | Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Siqi Zhao: h-index 31 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Chinese Academy of Sciences: institution h-index 1,801 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27717139) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 42 / 100 | — |
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Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Yin, J., Liu, X., He, Q., Zhou, L., Yuan, Z., & Zhao, S. (2016). Vps35-dependent recycling of Trem2 regulates microglial function. Traffic (Copenhagen, Denmark). https://doi.org/10.1111/tra.12451
Vancouver
Yin J, Liu X, He Q, Zhou L, Yuan Z, Zhao S. Vps35-dependent recycling of Trem2 regulates microglial function. Traffic (Copenhagen, Denmark). 2016. doi:10.1111/tra.12451. PMID: 27717139.
BibTeX
@article{yin2016-27717139,
author = {Yin, J. and Liu, X. and He, Q. and Zhou, L. and Yuan, Z. and Zhao, S.},
title = {{Vps35-dependent recycling of Trem2 regulates microglial function}},
journal = {Traffic (Copenhagen, Denmark)},
year = {2016},
doi = {10.1111/tra.12451},
pmid = {27717139},
url = {https://doi.org/10.1111/tra.12451}
}
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