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The effect of hormone replacement therapy on cognitive function in post-menopausal women
Lavi R, Doniger GM, Simon E, Hochner-Celnikier D, Zimran A, Elstein D.. QJM : monthly journal of the Association of Physicians, 2007-07-30
Topic: Risk, prevention and care in population studies
Background Despite interest in causes of dementia in older persons, particularly in post-menopausal women, it is unclear whether hormone replacement therapy (HRT) is a risk factor. Aim To assess cognitive function in post-menopausal women with high educational status receiving HRT, compared to non-users. Design Cognitive functioning was assessed with in women aged 55-60 years with at least university-level education, using the Mindstreams system, a computerized cognitive battery with multiple domains. Results Of 165 women meeting the inclusion/exclusion criteria, 82 women (49.7%) declined participation. Of the remaining 83, 40 (48.2%) had never received HRT; the remainder was divided into women receiving 5-9 years HRT (n = 29)versus those with >or=10 years HRT (n = 11). There were no statistically significant differences between HRT users and non-users in global scores or sub-domains of cognitive functioning, and no difference between those women receiving HRT for 5-9 years vs. >or=10 years. Discussions Long-term HRT does not appear to impair cognitive functioning in highly-educated women. Recommendations regarding post-menopausal HRT should be made on an individual basis.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Lavi, R., Doniger, G. M., Simon, E., Hochner-Celnikier, D., Zimran, A., & Elstein, D. (2007). The effect of hormone replacement therapy on cognitive function in post-menopausal women. QJM : monthly journal of the Association of Physicians. https://doi.org/10.1093/qjmed/hcm065
Vancouver
Lavi R, Doniger GM, Simon E, Hochner-Celnikier D, Zimran A, Elstein D. The effect of hormone replacement therapy on cognitive function in post-menopausal women. QJM : monthly journal of the Association of Physicians. 2007. doi:10.1093/qjmed/hcm065. PMID: 17664220.
BibTeX
@article{lavi2007-17664220,
author = {Lavi, R. and Doniger, G. M. and Simon, E. and Hochner-Celnikier, D. and Zimran, A. and Elstein, D.},
title = {{The effect of hormone replacement therapy on cognitive function in post-menopausal women}},
journal = {QJM : monthly journal of the Association of Physicians},
year = {2007},
doi = {10.1093/qjmed/hcm065},
pmid = {17664220},
url = {https://doi.org/10.1093/qjmed/hcm065}
}
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Key findings
- Aim To assess cognitive function in post-menopausal women with high educational status receiving HRT, compared to non-users.
- Results Of 165 women meeting the inclusion/exclusion criteria, 82 women (49.7%) declined participation.
- Of the remaining 83, 40 (48.2%) had never received HRT; the remainder was divided into women receiving 5-9 years HRT (n = 29)versus those with >or=10 years HRT (n = 11).
- There were no statistically significant differences between HRT users and non-users in global scores or sub-domains of cognitive functioning, and no difference between those women receiving HRT for 5-9 years vs. >or=10 years.
Study details
- Participants29
- Effect size49.7%; 48.2%
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 27 of the 58 points we could judge it on, which is 47 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (QJM : monthly journal of the Association of Physicians) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 29 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17664220) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 27 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 27 of the 58 points we could judge it on is 47 out of 100. |
| Total | 47 / 100 | — |
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