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38/100

✓ Peer-reviewed alzhub usefulness score 38 out of 100. Biomarkers

Topic: Amyloid, tau and blood-test diagnosis

PRS correlated positively with log-NFL (r = 0.31, p = 0.004) and inversely with N3 duration (r = −0.26, p = 0.017). The PRS × N3 interaction was negative (β = −0.31, p = 0.003), indicating a stronger PRS–NFL association at shorter N3 durations. The PRS × log-WASO interaction was not statistically significant (β = 0.14, p = 0.190). N3 duration modified the observed association between genetic susceptibility and plasma NFL. These cross-sectional findings do not establish causality or Alzheimer-specific pathology.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Riffaqat, A., Kanwal, S., Zahra, Z., Mirza, A. H., Khan, K. N., Nosherwani, S., et al. (2026). The Association Between Polygenic Risk for Alzheimer's, Objective Sleep Architecture, and Plasma Neurofilament Light Chain in Midlife. Journal of Health Wellness and Community Research. https://doi.org/10.61919/wyfc0r72

Vancouver

Riffaqat A, Kanwal S, Zahra Z, Mirza AH, Khan KN, Nosherwani S, et al. The Association Between Polygenic Risk for Alzheimer's, Objective Sleep Architecture, and Plasma Neurofilament Light Chain in Midlife. Journal of Health Wellness and Community Research. 2026. doi:10.61919/wyfc0r72.

BibTeX

@article{riffaqat2026-4ef9e396,
  author  = {Riffaqat, Asma and Kanwal, Sumera and Zahra, Zoha and Mirza, Ali Hamza and Khan, Kiran Naved and Nosherwani, Shama and Shaikh, Maaz Ubair},
  title   = {{The Association Between Polygenic Risk for Alzheimer's, Objective Sleep Architecture, and Plasma Neurofilament Light Chain in Midlife}},
  journal = {Journal of Health Wellness and Community Research},
  year    = {2026},
  doi     = {10.61919/wyfc0r72},
  url     = {https://doi.org/10.61919/wyfc0r72}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

PRS correlated positively with log-NFL (r = 0.31, p = 0.004) and inversely with N3 duration (r = −0.26, p = 0.017).
The PRS × N3 interaction was negative (β = −0.31, p = 0.003), indicating a stronger PRS–NFL association at shorter N3 durations.
The PRS × log-WASO interaction was not statistically significant (β = 0.14, p = 0.190).
N3 duration modified the observed association between genetic susceptibility and plasma NFL.
These cross-sectional findings do not establish causality or Alzheimer-specific pathology.

Why it matters

In midlife, higher polygenic risk for Alzheimer's correlated with higher plasma neurofilament light chain, and this association was stronger at shorter N3 sleep duration. The authors state these cross-sectional findings do not establish causality or Alzheimer-specific pathology.

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Study details

Study designcross-sectional
Participants84
Evidence strengthLow

How this study scored 38/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 36 of the 96 points we could judge it on, which is 38 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Health Wellness and Community Research)
Journal's citation record	0 / 4	Journal of Health Wellness and Community Research: journal h-index 3 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	1 / 4	84 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 2 year(s) since 2026
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	OpenAlex's profile for last-listed author Maaz Ubair Shaikh holds only 1 work(s), too few to judge a track record — left out of this score
Institution's track record	0 / 3	University of Essex: institution h-index 464 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 5 institution(s) in 2 countries
Indexed in PubMed	1 / 2	Not in PubMed, but has a DOI
Free to read	2 / 2	Free to read
Points	36 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 36 of the 96 points we could judge it on is 38 out of 100.
Total	38 / 100	—

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Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

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