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The Area Deprivation Index: A novel tool for harmonizable risk assessment in Alzheimer's disease research
Megan L. Zuelsdorff, Jamie L. Larson, Jack F.V. Hunt, Alice J. Kim, Rebecca L. Koscik, William R. Buckingham, Carey Elizabeth Gleason, Sterling C. Johnson et al.. Alzheimer s & Dementia Translational Research & Clinical Interventions, 2020-01-01
Topic: Amyloid, tau and blood-test diagnosis
Participants in the most disadvantaged neighborhoods (n = 156) were younger, more often female, and less often college-educated or white than those in less disadvantaged neighborhoods (n = 1963). Disadvantaged neighborhood residence associated with poorer performance on tests of executive function, verbal learning, and memory. This geospatial metric of neighborhood disadvantage may be valuable for exploring socially rooted risk mechanisms, and prioritizing high-risk communities for research recruitment and intervention.
Key findings
- Participants in the most disadvantaged neighborhoods (n = 156) were younger, more often female, and less often college-educated or white than those in less disadvantaged neighborhoods (n = 1963).
- Disadvantaged neighborhood residence associated with poorer performance on tests of executive function, verbal learning, and memory.
- This geospatial metric of neighborhood disadvantage may be valuable for exploring socially rooted risk mechanisms, and prioritizing high-risk communities for research recruitment and intervention.
Why it matters
This study found that living in the most disadvantaged neighborhoods was associated with poorer performance on tests of executive function, verbal learning, and memory. It suggests that this geospatial measure of neighborhood disadvantage may be useful for exploring socially rooted risk mechanisms and prioritizing high-risk communities for research and intervention.
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Study details
- Participants156
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia Translational Research & Clinical Interventions) |
| Journal's citation record | 1 / 4 | Alzheimer s & Dementia Translational Research & Clinical Interventions: journal h-index 84 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 156 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 103 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 12.9 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 7.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 58 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Amy Kind: h-index 47 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California San Diego: institution h-index 1,852 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32548238) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1002/trc2.12039
- PubMed: 32548238
- Original source →
- Free full text: Alzheimer s & Dementia Translational Research & Clinical Interventions →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Zuelsdorff, M. L., Larson, J. L., Hunt, J. F., Kim, A. J., Koscik, R. L., Buckingham, W. R., et al. (2020). The Area Deprivation Index: A novel tool for harmonizable risk assessment in Alzheimer's disease research. Alzheimer s & Dementia Translational Research & Clinical Interventions. https://doi.org/10.1002/trc2.12039
Vancouver
Zuelsdorff ML, Larson JL, Hunt JF, Kim AJ, Koscik RL, Buckingham WR, et al. The Area Deprivation Index: A novel tool for harmonizable risk assessment in Alzheimer's disease research. Alzheimer s & Dementia Translational Research & Clinical Interventions. 2020. doi:10.1002/trc2.12039. PMID: 32548238.
BibTeX
@article{zuelsdorff2020-32548238,
author = {Zuelsdorff, Megan L. and Larson, Jamie L. and Hunt, Jack F.V. and Kim, Alice J. and Koscik, Rebecca L. and Buckingham, William R. and Gleason, Carey Elizabeth and Johnson, Sterling C. and others},
title = {{The Area Deprivation Index: A novel tool for harmonizable risk assessment in Alzheimer's disease research}},
journal = {Alzheimer s \& Dementia Translational Research \& Clinical Interventions},
year = {2020},
doi = {10.1002/trc2.12039},
pmid = {32548238},
url = {https://doi.org/10.1002/trc2.12039}
}
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