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Stable isotope labelling kinetics of neurofilament light
Claire Alexandra Leckey, Tatiana A. Giovannucci, John B. Coulton, Yingxin He, Chihiro Sato, Nupur Ghoshal, Tharini Vignarajah, Zane Jaunmuktane et al.. Brain Communications, 2025-01-01
Topic: Brain proteins, microglia and lab models
These findings support the interpretation that acute rises in CSF NfL concentration are likely to be related to passive release or CSF clearance failure.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Leckey, C. A., Giovannucci, T. A., Coulton, J. B., He, Y., Sato, C., Ghoshal, N., et al. (2025). Stable isotope labelling kinetics of neurofilament light. Brain Communications. https://doi.org/10.1093/braincomms/fcaf468
Vancouver
Leckey CA, Giovannucci TA, Coulton JB, He Y, Sato C, Ghoshal N, et al. Stable isotope labelling kinetics of neurofilament light. Brain Communications. 2025. doi:10.1093/braincomms/fcaf468. PMID: 41416248.
BibTeX
@article{leckey2025-41416248,
author = {Leckey, Claire Alexandra and Giovannucci, Tatiana A. and Coulton, John B. and He, Yingxin and Sato, Chihiro and Ghoshal, Nupur and Vignarajah, Tharini and Jaunmuktane, Zane and others},
title = {{Stable isotope labelling kinetics of neurofilament light}},
journal = {Brain Communications},
year = {2025},
doi = {10.1093/braincomms/fcaf468},
pmid = {41416248},
url = {https://doi.org/10.1093/braincomms/fcaf468}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- These findings support the interpretation that acute rises in CSF NfL concentration are likely to be related to passive release or CSF clearance failure.
Why it matters
This study supports the interpretation that acute rises in cerebrospinal fluid neurofilament light are likely related to passive release or clearance failure. It is about a biomarker's behavior and does not test a treatment for Alzheimer's disease.
Study details
- Evidence strengthModerate
How this study scored 44/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain Communications) |
| Journal's citation record | 0 / 4 | Brain Communications: journal h-index 67 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 5 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Ross W. Paterson: h-index 43 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | University of Washington: institution h-index 3,540 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 10 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41416248) |
| Free to read | 2 / 2 | Free to read |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1093/braincomms/fcaf468
- PubMed: 41416248
- Original source →
- Free full text: Brain Communications →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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