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Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation
Fabre T, Barron AMS, Christensen SM, Asano S, Bound K, Lech MP, Wadsworth MH, Chen X et al.. Science immunology, 2023-04-07
Topic: Brain proteins, microglia and lab models
Macrophages are central orchestrators of the tissue response to injury, with distinct macrophage activation states playing key roles in fibrosis progression and resolution. Identifying key macrophage populations found in human fibrotic tissues could lead to new treatments for fibrosis. Here, we used human liver and lung single-cell RNA sequencing datasets to identify a subset of CD9 + TREM2 + macrophages that express SPP1 , GPNMB , FABP5 , and CD63 .
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Fabre, T., Barron, A. M. S., Christensen, S. M., Asano, S., Bound, K., Lech, M. P., et al. (2023). Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation. Science immunology. https://doi.org/10.1126/sciimmunol.add8945
Vancouver
Fabre T, Barron AMS, Christensen SM, Asano S, Bound K, Lech MP, et al. Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation. Science immunology. 2023. doi:10.1126/sciimmunol.add8945. PMID: 37027478.
BibTeX
@article{fabre2023-37027478,
author = {Fabre, T. and Barron, A. M. S. and Christensen, S. M. and Asano, S. and Bound, K. and Lech, M. P. and Wadsworth, M. H. and Chen, X. and others},
title = {{Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation}},
journal = {Science immunology},
year = {2023},
doi = {10.1126/sciimmunol.add8945},
pmid = {37027478},
url = {https://doi.org/10.1126/sciimmunol.add8945}
}
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Key findings
- Identifying key macrophage populations found in human fibrotic tissues could lead to new treatments for fibrosis.
- Here, we used human liver and lung single-cell RNA sequencing datasets to identify a subset of CD9 + TREM2 + macrophages that express SPP1 , GPNMB , FABP5 , and CD63 .
- In both human and murine hepatic and pulmonary fibrosis, these macrophages were enriched at the outside edges of scarring and adjacent to activated mesenchymal cells.
- Neutrophils expressing MMP9, which participates in the activation of TGF-β1, and the type 3 cytokines GM-CSF and IL-17A coclustered with these macrophages.
Why it matters
This study identified a macrophage subset in human liver and lung fibrosis, not Alzheimer's disease. It does not test any Alzheimer's treatment, cure, or prevention.
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Study details
- Evidence strengthLow
How this study scored 53/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Science immunology) |
| Journal's citation record | 2 / 4 | Science Immunology: journal h-index 164 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 347 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 69.4 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 6 / 6 | Cited 49.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 4 / 4 | Cited 319 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Ken Dower: h-index 24 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Edinburgh: institution h-index 1,378 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37027478) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 53 / 100 | — |
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