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51/100

✓ Peer-reviewed alzhub usefulness score 51 out of 100. Genetics

Topic: Amyloid, tau and blood-test diagnosis

RBC DHA was associated with a positive (improved) global cognition (PACC) rate of change (estimate: 0.011; 95% CI: 0.001, 0.021; P = 0.024). No statistically significant interactions were observed for sex, APOE-ε4 carriership, or AD pathology. Higher RBC ALA status was associated with positive rate of change (better performing) in visual processing (estimate: 0.425; 95% CI: 0.168, 0.682; P = 0.001). In individuals at risk of AD, RBC DHA and RBC ALA show positive associations with longitudinal cognition. These findings add to the observational evidence linking ω-3 FAs with improved brain health. This trial was registered at clinicaltrials.gov as NCT02485730 (https://clinicaltrials.gov/study/NCT02485730).

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APA 7th

Lázaro, I., Brugulat‐Serrat, A., Suárez‐Calvet, M., Fauria, K., Minguillón, C., Gispert, J. D., et al. (2025). Red blood cell ω-3 status and longitudinal cognition in individuals at risk of Alzheimer disease. Journal of Nutrition. https://doi.org/10.1016/j.tjnut.2025.09.032

Vancouver

Lázaro I, Brugulat‐Serrat A, Suárez‐Calvet M, Fauria K, Minguillón C, Gispert JD, et al. Red blood cell ω-3 status and longitudinal cognition in individuals at risk of Alzheimer disease. Journal of Nutrition. 2025. doi:10.1016/j.tjnut.2025.09.032. PMID: 41022152.

BibTeX

@article{lazaro2025-41022152,
  author  = {Lázaro, Iolanda and Brugulat‐Serrat, Anna and Suárez‐Calvet, Marc and Fauria, Karine and Minguillón, Carolina and Gispert, Juan Domingo and Molinuevo, José Luís and Harris, William S. and others},
  title   = {{Red blood cell ω-3 status and longitudinal cognition in individuals at risk of Alzheimer disease}},
  journal = {Journal of Nutrition},
  year    = {2025},
  doi     = {10.1016/j.tjnut.2025.09.032},
  pmid    = {41022152},
  url     = {https://doi.org/10.1016/j.tjnut.2025.09.032}
}

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Key findings

RBC DHA was associated with a positive (improved) global cognition (PACC) rate of change (estimate: 0.011; 95% CI: 0.001, 0.021; P = 0.024).
No statistically significant interactions were observed for sex, APOE-ε4 carriership, or AD pathology.
Higher RBC ALA status was associated with positive rate of change (better performing) in visual processing (estimate: 0.425; 95% CI: 0.168, 0.682; P = 0.001).
In individuals at risk of AD, RBC DHA and RBC ALA show positive associations with longitudinal cognition.
These findings add to the observational evidence linking ω-3 FAs with improved brain health.

Why it matters

In individuals at risk of Alzheimer disease, higher red blood cell DHA was associated with improved global cognition rate of change and higher ALA with better visual processing, with no significant interactions for sex, APOE-ε4 carriership, or AD pathology. These are observational associations, and the authors say they add to observational evidence linking ω-3 fatty acids with brain health.

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Study details

Study designlongitudinal study
Participants323
Evidence strengthModerate

How this study scored 51/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 49 of the 96 points we could judge it on, which is 51 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Nutrition)
Journal's citation record	3 / 4	Journal of Nutrition: journal h-index 372 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	323 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	0 / 3	Instituto de Salud Carlos III: institution h-index 649 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 9 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41022152)
Free to read	2 / 2	Free to read
Points	49 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 49 of the 96 points we could judge it on is 51 out of 100.
Total	51 / 100	—

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