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Quantitative electroencephalography in the diagnosis of dementia with Lewy bodies
Abhimanyu Mahajan, Alberto Jaramillo-Jiménez, Anita D’Anselmo, Giulia Prete, Lucrezia Bristot, Sara Varanese, Alberto Di Domenico, Nicola Mammarella et al.. Clinical Neurophysiology Practice, 2025-01-01
Topic: Risk, prevention and care in population studies
The spectral analysis of the resting-state eyes-closed electroencephalographic (rsEEG) activity typically shows abnormal delta (< 4 Hz), theta (4-7 Hz), and alpha (8-12 Hz) power in older patients with cognitive deficits due to progressive neurodegenerative diseases. Interestingly, abnormally prominent posterior rsEEG power < 8 Hz with periodic fluctuations in the pre-alpha/theta range has been considered a supportive biomarker for diagnosing patients with prodromal or manifest dementia due to Lewy bodies (DLB) in international guidelines. Here, a panel of experts shortly reviews the concepts of thalamocortical dysrhythmia as a possible neurophysiological oscillatory mechanism generating those rsEEG abnormalities in DLB patients. It also recommends how to record and quantitatively analyze rsEEG activity in prodromal and manifesting DLB patients for the application of that cost-effective and largely available diagnostic procedure in clinical practice.
Key findings
- The spectral analysis of the resting-state eyes-closed electroencephalographic (rsEEG) activity typically shows abnormal delta (< 4 Hz), theta (4-7 Hz), and alpha (8-12 Hz) power in older patients with cognitive deficits due to progressive neurodegenerative diseases.
- Interestingly, abnormally prominent posterior rsEEG power < 8 Hz with periodic fluctuations in the pre-alpha/theta range has been considered a supportive biomarker for diagnosing patients with prodromal or manifest dementia due to Lewy bodies (DLB) in international guidelines.
- Here, a panel of experts shortly reviews the concepts of thalamocortical dysrhythmia as a possible neurophysiological oscillatory mechanism generating those rsEEG abnormalities in DLB patients.
- It also recommends how to record and quantitatively analyze rsEEG activity in prodromal and manifesting DLB patients for the application of that cost-effective and largely available diagnostic procedure in clinical practice.
Why it matters
This expert review recommends how to record and quantitatively analyze resting-state electroencephalography in prodromal and manifest dementia with Lewy bodies, noting that abnormally prominent posterior power below 8 Hz is considered a supportive diagnostic biomarker. It is about diagnosis, not treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 37/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Clinical Neurophysiology Practice) |
| Journal's citation record | 0 / 4 | Clinical Neurophysiology Practice: journal h-index 37 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Laura Bonanni: h-index 56 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | King's College London: institution h-index 1,348 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 4 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40687078) |
| Free to read | 2 / 2 | Free to read |
| Total | 37 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.cnp.2025.06.008
- PubMed: 40687078
- Original source →
- Free full text: Clinical Neurophysiology Practice →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Mahajan, A., Jaramillo-Jiménez, A., D’Anselmo, A., Prete, G., Bristot, L., Varanese, S., et al. (2025). Quantitative electroencephalography in the diagnosis of dementia with Lewy bodies. Clinical Neurophysiology Practice. https://doi.org/10.1016/j.cnp.2025.06.008
Vancouver
Mahajan A, Jaramillo-Jiménez A, D’Anselmo A, Prete G, Bristot L, Varanese S, et al. Quantitative electroencephalography in the diagnosis of dementia with Lewy bodies. Clinical Neurophysiology Practice. 2025. doi:10.1016/j.cnp.2025.06.008. PMID: 40687078.
BibTeX
@article{mahajan2025-40687078,
author = {Mahajan, Abhimanyu and Jaramillo-Jiménez, Alberto and D’Anselmo, Anita and Prete, Giulia and Bristot, Lucrezia and Varanese, Sara and Di Domenico, Alberto and Mammarella, Nicola and others},
title = {{Quantitative electroencephalography in the diagnosis of dementia with Lewy bodies}},
journal = {Clinical Neurophysiology Practice},
year = {2025},
doi = {10.1016/j.cnp.2025.06.008},
pmid = {40687078},
url = {https://doi.org/10.1016/j.cnp.2025.06.008}
}
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