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Quantification of Tau Load Using [18F]AV1451 PET
Golla SSV, Timmers T, Ossenkoppele R, Groot C, Verfaillie S, Scheltens P, van der Flier WM, Schwarte L et al.. Molecular imaging and biology, 2017-12-01
Topic: Brain proteins, microglia and lab models
Purpose The tau tracer [ 18 F]AV1451, also known as flortaucipir, is a promising ligand for imaging tau accumulation in Alzheimer's disease (AD). Most of the previous studies have quantified tau load using standardized uptake value ratios (SUVr) derived from a static [ 18 F]AV1451 scan. SUVr may, however, be flow dependent and, especially for longitudinal studies, should be validated against a fully quantitative approach. The objective of this study was to identify the optimal tracer kinetic model for measuring tau load using [ 18 F]AV1451. Procedures Following intravenous injection of 225 ± 16 MBq [ 18 F]AV1451, 130 min dynamic PET scans were performed in five biomarker confirmed AD patients and five controls. Arterial blood sampling was performed to obtain a metabolite-corrected plasma input function. Next, regional time-activity curves were generated using PVElab software. These curves were analysed using several pharmacokinetic models. Results The reversible single tissue compartment model (1T2k_V B ) was the preferred model for all but one control. For AD patients, however, model preference shifted towards a reversible two tissue compartmental model (2T4k_V B ). The simplified reference tissue model (SRTM) derived binding potential (BP ND ) showed good correlation (AD: r 2 = 0.87, slope = 1.06; controls: r 2 = 0.87, slope = 0.86) with indirect plasma input binding (distribution volume ratio-1). Standardized uptake value ratios (80-100 min) correlated well with DVR (r 2 = 0.93, slope = 1.07) and SRTM-derived BP ND (r 2 = 0.84, slope = 0.95). In addition, regional differences in tracer binding between subject groups in different tau-specific regions were observed. Conclusions Model preference of [ 18 F]AV1451 appears to depend on subject status and, in particular, V T . The relationship between model preference and V T suggests that (higher) tau load may be reflected by a second tissue compartment. Nevertheless, consistent results can be obtained using a 2T4k_V B model. In addition, SRTM can be used to derive BP ND .
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APA 7th
Golla, S. S. V., Timmers, T., Ossenkoppele, R., Groot, C., Verfaillie, S., Scheltens, P., et al. (2017). Quantification of Tau Load Using [18F]AV1451 PET. Molecular imaging and biology. https://doi.org/10.1007/s11307-017-1080-z
Vancouver
Golla SSV, Timmers T, Ossenkoppele R, Groot C, Verfaillie S, Scheltens P, et al. Quantification of Tau Load Using [18F]AV1451 PET. Molecular imaging and biology. 2017. doi:10.1007/s11307-017-1080-z. PMID: 28374171.
BibTeX
@article{golla2017-28374171,
author = {Golla, S. S. V. and Timmers, T. and Ossenkoppele, R. and Groot, C. and Verfaillie, S. and Scheltens, P. and van der Flier, W. M. and Schwarte, L. and others},
title = {{Quantification of Tau Load Using [18F]AV1451 PET}},
journal = {Molecular imaging and biology},
year = {2017},
doi = {10.1007/s11307-017-1080-z},
pmid = {28374171},
url = {https://doi.org/10.1007/s11307-017-1080-z}
}
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Key findings
- Results The reversible single tissue compartment model (1T2k_V B ) was the preferred model for all but one control.
- The relationship between model preference and V T suggests that (higher) tau load may be reflected by a second tissue compartment.
- Nevertheless, consistent results can be obtained using a 2T4k_V B model.
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Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 57/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 33 of the 58 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Molecular imaging and biology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28374171) |
| Free to read | 2 / 2 | Free to read |
| Points | 33 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 33 of the 58 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
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