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46/100

✓ Peer-reviewed alzhub usefulness score 46 out of 100. Tau biomarkers

Topic: Amyloid, tau and blood-test diagnosis

A higher DMV score was significantly associated with increased likelihoods of MCI (OR=1.19; 95%CI=1.06‒1.34) and amnestic mild cognitive impairment (aMCI) (1.21; 1.06‒1.37), and lower scores in MMSE (-0.01; -0.02‒0.00; p = 0.041), global cognition (-0.05; -0.08‒-0.03), memory (-0.06; -0.10‒-0.02), verbal fluency (-0.05; -0.08‒-0.02), attention (-0.04; -0.07‒-0.01), and executive function (-0.06; -0.10‒-0.03). In the plasma biomarker subsample, a higher DMV score was significantly related to lower amyloid-β42/amyloid-β40 ratio (β = -0.11; -0.20‒-0.02). This study suggests that the discontinuation of DMVs is associated with MCI and aMCI, poor function in global cognition and multiple cognitive domains, and Alzheimer pathology in rural Chinese older adults.

Key findings

A higher DMV score was significantly associated with increased likelihoods of MCI (OR=1.19; 95%CI=1.06‒1.34) and amnestic mild cognitive impairment (aMCI) (1.21; 1.06‒1.37), and lower scores in MMSE (-0.01; -0.02‒0.00; p = 0.041), global cognition (-0.05; -0.08‒-0.03), memory (-0.06; -0.10‒-0.02), verbal fluency (-0.05; -0.08‒-0.02), attention (-0.04; -0.07‒-0.01), and executive function (-0.06; -0.10‒-0.03).
In the plasma biomarker subsample, a higher DMV score was significantly related to lower amyloid-β42/amyloid-β40 ratio (β = -0.11; -0.20‒-0.02).
This study suggests that the discontinuation of DMVs is associated with MCI and aMCI, poor function in global cognition and multiple cognitive domains, and Alzheimer pathology in rural Chinese older adults.

Why it matters

In dementia-free older adults in rural China, a higher deep medullary vein score was associated with increased likelihood of mild cognitive impairment and lower scores in several cognitive domains, as well as a lower plasma amyloid-β42/amyloid-β40 ratio. This cross-sectional study suggests vein abnormalities are linked to cognitive function and Alzheimer's pathology, but it cannot show cause and effect and does not test any treatment.

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Study details

Study designcross-sectional
Participants903
Effect sizeOR=1.19
Evidence strengthLow

How this study scored 46/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	903 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Chengxuan Qiu: h-index 66 (OpenAlex, whole career)
Institution's track record	1 / 3	Karolinska Institutet: institution h-index 1,477 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 5 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41434411)
Free to read	2 / 2	Free to read
Total	46 / 100	—

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Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Yin, D., Wang, J., Li, C., Wang, X., Wang, Y., Xie, Q., et al. (2025). Deep medullary vein abnormalities associated with cognitive function and Alzheimer's disease plasma biomarkers in dementia‐free older adults: The MIND‐China Study. Alzheimer s & Dementia. https://doi.org/10.1002/alz70860_102602

Vancouver

Yin D, Wang J, Li C, Wang X, Wang Y, Xie Q, et al. Deep medullary vein abnormalities associated with cognitive function and Alzheimer's disease plasma biomarkers in dementia‐free older adults: The MIND‐China Study. Alzheimer s & Dementia. 2025. doi:10.1002/alz70860_102602. PMID: 41434411.

BibTeX

@article{yin2025-41434411,
  author  = {Yin, Dejia and Wang, Jiafeng and Li, Chunyan and Wang, Xiaoyu and Wang, Yan and Xie, Qianqian and Zhang, Huisi and Chen, Ziwei and others},
  title   = {{Deep medullary vein abnormalities associated with cognitive function and Alzheimer's disease plasma biomarkers in dementia‐free older adults: The MIND‐China Study}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70860_102602},
  pmid    = {41434411},
  url     = {https://doi.org/10.1002/alz70860_102602}
}

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