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Primary progressive apraxia in Pick's disease: a clinicopathologic study
Fukui T, Sugita K, Kawamura M, Shiota J, Nakano I.. Neurology, 1996-08-01
Topic: Brain proteins, microglia and lab models
A 62-year-old right-handed man gradually experienced increasing difficulty with speech and manual dexterity. He had apraxia of speech, buccofacial apraxia, and complex limb apraxia as well as terminal dementia. At autopsy, focal cortical atrophy, neuronal loss, and neuropil rarefaction in the second and third cortical layers were most prominent in the left opercular, lower precentral, superior parietal, and left temporal pole. Numerous Pick bodies were diffusely present in the temporal and posterior frontal lobes and, to a lesser degree, in the superior parietal lobule. This report demonstrates an association between the distribution of Pick's pathology and several apraxic impairments.
Key findings
- A 62-year-old right-handed man gradually experienced increasing difficulty with speech and manual dexterity.
- He had apraxia of speech, buccofacial apraxia, and complex limb apraxia as well as terminal dementia.
- At autopsy, focal cortical atrophy, neuronal loss, and neuropil rarefaction in the second and third cortical layers were most prominent in the left opercular, lower precentral, superior parietal, and left temporal pole.
- Numerous Pick bodies were diffusely present in the temporal and posterior frontal lobes and, to a lesser degree, in the superior parietal lobule.
- This report demonstrates an association between the distribution of Pick's pathology and several apraxic impairments.
Why it matters
This clinicopathologic report describes a man with apraxia of speech, buccofacial apraxia and complex limb apraxia who developed terminal dementia, with Pick bodies found diffusely in the temporal and posterior frontal lobes and, to a lesser degree, in the superior parietal lobule. It is a single case report linking the distribution of Pick's pathology to apraxic impairments and reports no treatment, cure or prevention.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1996 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 82 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.6 citations a year over 32 year(s) since 1996 |
| Impact for its field and year | 3 / 6 | Cited 3.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Imaharu Nakano: h-index 54 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | SHOWA Medical University: institution h-index 420 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 8757022) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
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Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Fukui, T., Sugita, K., Kawamura, M., Shiota, J., & Nakano, I. (1996). Primary progressive apraxia in Pick's disease: a clinicopathologic study. Neurology. https://doi.org/10.1212/wnl.47.2.467
Vancouver
Fukui T, Sugita K, Kawamura M, Shiota J, Nakano I. Primary progressive apraxia in Pick's disease: a clinicopathologic study. Neurology. 1996. doi:10.1212/wnl.47.2.467. PMID: 8757022.
BibTeX
@article{fukui1996-8757022,
author = {Fukui, T. and Sugita, K. and Kawamura, M. and Shiota, J. and Nakano, I.},
title = {{Primary progressive apraxia in Pick's disease: a clinicopathologic study}},
journal = {Neurology},
year = {1996},
doi = {10.1212/wnl.47.2.467},
pmid = {8757022},
url = {https://doi.org/10.1212/wnl.47.2.467}
}
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