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Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia
Mendez MF, Shapira JS, McMurtray A, Licht E.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2007-01-01
Topic: Risk, prevention and care in population studies
Objective The objective of this study was to evaluate donepezil, an acetylcholinesterase inhibitor, in the treatment of frontotemporal dementia (FTD). Methods Twelve patients with FTD who received donepezil for six months were compared with 12 FTD controls on behavioral measures. Results The groups did not differ on most variables at baseline or at six months; however, the donepezil group had greater worsening on the FTD Inventory. Four treated patients had increased disinhibited or compulsive acts, which abated with discontinuation of the medication. Conclusion There were no changes in global cognitive performance or dementia severity; however, a subgroup of patients with FTD can experience worsening of symptoms with donepezil.
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APA 7th
Mendez, M. F., Shapira, J. S., McMurtray, A., & Licht, E. (2007). Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. https://doi.org/10.1097/01.jgp.0000231744.69631.33
Vancouver
Mendez MF, Shapira JS, McMurtray A, Licht E. Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2007. doi:10.1097/01.jgp.0000231744.69631.33. PMID: 17194818.
BibTeX
@article{mendez2007-17194818,
author = {Mendez, M. F. and Shapira, J. S. and McMurtray, A. and Licht, E.},
title = {{Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia}},
journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
year = {2007},
doi = {10.1097/01.jgp.0000231744.69631.33},
pmid = {17194818},
url = {https://doi.org/10.1097/01.jgp.0000231744.69631.33}
}
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Key findings
- Methods Twelve patients with FTD who received donepezil for six months were compared with 12 FTD controls on behavioral measures.
- Results The groups did not differ on most variables at baseline or at six months; however, the donepezil group had greater worsening on the FTD Inventory.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 24 of the 58 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17194818) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 24 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 24 of the 58 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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