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frontotemporal-dementia
10 studies tagged frontotemporal-dementia, dated 2013-05-29 to 2023-01-08. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Assessment of Plasma and Cerebrospinal Fluid Biomarkers in Different Stages of Alzheimer's Disease and Frontotemporal Dementia 2023-01-08
- Serum neurofilament light chain as a surrogate of cognitive decline in sporadic and familial frontotemporal dementia 2021-09-03
- Synergistic Association between Plasma Aβ1-42 and p-tau in Alzheimer's Disease but Not in Parkinson's Disease or Frontotemporal Dementia 2021-04-07
Studies
10 studies carry this tag.
Date range
2013 to 2023
Top journals
- Journal of neurology, neurosurgery, and psychiatry 3
- ACS chemical neuroscience 1
- Alzheimer's & dementia (Amsterdam, Netherlands) 1
- BMC neurology 1
- Dementia and geriatric cognitive disorders 1
8 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Alzheimer's disease (AD) is the primary type of dementia, followed by frontotemporal lobar degeneration (FTLD).
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Our findings highlight the potential of serum NfL as a useful surrogate end point of disease severity in upcoming targeted treatments.
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Beta-amyloid (Aβ 1-42 ) triggers the phosphorylation of tau protein in Alzheimer's disease (AD), but the relationship between phosphorylated tau (p-tau) and Aβ 1-42 in the blood is not elucidated.
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The frontotemporal dementia (FTD) spectrum of neurodegenerative disorders includes a heterogeneous group of conditions.
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CSF YKL-40 and chitotriosidase levels are increased in individuals with clinical FTD syndromes, particularly due to AD pathology.
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We conclude that NPTX2 is a promising synapse-derived disease progression biomarker in genetic FTD.
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Comparable performance of CSF and blood NfL in many groups demonstrates the promise of NfL as a noninvasive biomarker of neurodegeneration; however, its utility in clinically meaningful scenarios requires greater scrutiny.
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Our data indicate that neuroinflammation is linked to the symptomatic phase of ALS/FTD and shows a similar pattern in sporadic and genetic cases.
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57/100
NfL and p/t-tau similarly discriminated FTD from controls, but not between clinical subtypes, apart from FTD-MND.
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40/100
The marked NFL elevation in some but not all FTD cases is likely to reflect the different underlying pathologies.