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Alzheimer´s disease and oxidative stress: a review
Pohanka M.. Current medicinal chemistry, 2014-01-01
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer´s disease (AD) is a neurodegenerative disorder with no known cure and rapid rise in incidence. The predominant cognitive impairment is currently treated using cognitive enhancers like cholinesterase inhibitors. The two molecular hallmarks of AD are amyloid plaques created from an amyloid precursor protein and hyperphosphorylated tau protein that is deposited as neurofibrillary tangles inside neurons.
Key findings
- The predominant cognitive impairment is currently treated using cognitive enhancers like cholinesterase inhibitors.
- The two molecular hallmarks of AD are amyloid plaques created from an amyloid precursor protein and hyperphosphorylated tau protein that is deposited as neurofibrillary tangles inside neurons.
- A number of pathological mechanisms follow or precede these formations.
- Alteration in mitochondrial function and deposition of heavy metals are reported.
Why it matters
This review notes that Alzheimer's disease has no known cure and that current treatment mainly uses cognitive enhancers such as cholinesterase inhibitors. It describes molecular hallmarks and possible pathological mechanisms but reports no new treatment or preventive intervention.
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Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Current medicinal chemistry) |
| Journal's citation record | 2 / 4 | Current Medicinal Chemistry: journal h-index 229 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 218 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 15.6 citations a year over 14 year(s) since 2014 |
| Impact for its field and year | 4 / 6 | Cited 13.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 20 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Miroslav Pohanka: h-index 49 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | University of Defence: institution h-index 108 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24059239) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Pohanka, M. (2014). Alzheimer´s disease and oxidative stress: a review. Current medicinal chemistry. https://doi.org/10.2174/09298673113206660258
Vancouver
Pohanka M. Alzheimer´s disease and oxidative stress: a review. Current medicinal chemistry. 2014. doi:10.2174/09298673113206660258. PMID: 24059239.
BibTeX
@article{pohanka2014-24059239,
author = {Pohanka, M.},
title = {{Alzheimer´s disease and oxidative stress: a review}},
journal = {Current medicinal chemistry},
year = {2014},
doi = {10.2174/09298673113206660258},
pmid = {24059239},
url = {https://doi.org/10.2174/09298673113206660258}
}
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