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Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study
Whitwell JL, Dickson DW, Murray ME, Weigand SD, Tosakulwong N, Senjem ML, Knopman DS, Boeve BF et al.. The Lancet. Neurology, 2012-09-03
Topic: Amyloid, tau and blood-test diagnosis
Compared with typical AD, hippocampal-sparing AD has more neurofibrillary tangles in the cortex and fewer in the hippocampus, whereas the opposite pattern is seen in limbic-predominant AD.
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APA 7th
Whitwell, J. L., Dickson, D. W., Murray, M. E., Weigand, S. D., Tosakulwong, N., Senjem, M. L., et al. (2012). Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study. The Lancet. Neurology. https://doi.org/10.1016/s1474-4422(12)70200-4
Vancouver
Whitwell JL, Dickson DW, Murray ME, Weigand SD, Tosakulwong N, Senjem ML, et al. Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study. The Lancet. Neurology. 2012. doi:10.1016/s1474-4422(12)70200-4. PMID: 22951070.
BibTeX
@article{whitwell2012-22951070,
author = {Whitwell, J. L. and Dickson, D. W. and Murray, M. E. and Weigand, S. D. and Tosakulwong, N. and Senjem, M. L. and Knopman, D. S. and Boeve, B. F. and others},
title = {{Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study}},
journal = {The Lancet. Neurology},
year = {2012},
doi = {10.1016/s1474-4422(12)70200-4},
pmid = {22951070},
url = {https://doi.org/10.1016/s1474-4422(12)70200-4}
}
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Key findings
- Compared with typical AD, hippocampal-sparing AD has more neurofibrillary tangles in the cortex and fewer in the hippocampus, whereas the opposite pattern is seen in limbic-predominant AD.
Why it matters
This case-control study reports that, compared with typical Alzheimer's disease, hippocampal-sparing Alzheimer's disease has more neurofibrillary tangles in the cortex and fewer in the hippocampus, while the opposite pattern is seen in limbic-predominant Alzheimer's disease. It describes differences between pathological subtypes and does not report any treatment, cure or prevention.
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Study details
- Evidence strengthLow
How this study scored 53/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Lancet. Neurology) |
| Journal's citation record | 3 / 4 | The Lancet Neurology: journal h-index 457 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2012 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 442 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 27.6 citations a year over 16 year(s) since 2012 |
| Impact for its field and year | 4 / 6 | Cited 12.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 28 other studies in this library |
| Still being cited | 3 / 4 | Cited 82 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Keith A. Josephs: h-index 119 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Mayo Clinic: institution h-index 1,606 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 22951070) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 53 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/s1474-4422(12)70200-4
- PubMed: 22951070
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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