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Recent advances in the detection and management of motor dysfunction in Alzheimer's disease
Marogianni C, Siokas V, Dardiotis E.. Psychiatrike = Psychiatriki, 2025-05-14
Topic: Amyloid, tau and blood-test diagnosis
However, there is growing recognition of the significant impact of motor dysfunction in individuals affected by AD. The temporal relationship between motor and cognitive decline is under intense investigation, with studies suggesting that subtle motor changes, such as gait and balance disturbances or slowed walking speed, may precede detectable cognitive impairment by several years.2 Specifically, research indicates that gait speed predicts a decline in processing speed and visuospatial abilities, and in ApoE4 carriers, it also predicts a memory decline.3 One study found that increased amyloid-beta (Aβ) deposition is associated with reduced gait speed, muscle strength, and balance in cognitively impaired older adults.4 Emerging evidence strongly supports the inclusion of motor function assessments, particularly gait analysis, in the early detection and risk stratification of AD. Advanced MRI techniques, such as diffusion tensor imaging (DTI), are used to assess white matter integrity along motor pathways, while molecular PET imaging can visualize amyloid and tau pathology in brain regions associated with motor control.7 Of note, tau pathology in higher motor regions has been significantly associated with cognitive decline. Improving mobility, balance, and functional independence may result in greater patients' autonomy and reduced physical and emotional strain on caregivers.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Marogianni, C., Siokas, V., & Dardiotis, E. (2025). Recent advances in the detection and management of motor dysfunction in Alzheimer's disease. Psychiatrike = Psychiatriki. https://doi.org/10.22365/jpsych.2025.012
Vancouver
Marogianni C, Siokas V, Dardiotis E. Recent advances in the detection and management of motor dysfunction in Alzheimer's disease. Psychiatrike = Psychiatriki. 2025. doi:10.22365/jpsych.2025.012. PMID: 40400272.
BibTeX
@article{marogianni2025-40400272,
author = {Marogianni, C. and Siokas, V. and Dardiotis, E.},
title = {{Recent advances in the detection and management of motor dysfunction in Alzheimer's disease}},
journal = {Psychiatrike = Psychiatriki},
year = {2025},
doi = {10.22365/jpsych.2025.012},
pmid = {40400272},
url = {https://doi.org/10.22365/jpsych.2025.012}
}
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Key findings
- However, there is growing recognition of the significant impact of motor dysfunction in individuals affected by AD.
- The temporal relationship between motor and cognitive decline is under intense investigation, with studies suggesting that subtle motor changes, such as gait and balance disturbances or slowed walking speed, may precede detectable cognitive impairment by several years.2 Specifically, research indicates that gait speed predicts a decline in processing speed and visuospatial abilities, and in ApoE4 carriers, it also predicts a memory decline.3 One study found that increased amyloid-beta (Aβ) deposition is associated with reduced gait speed, muscle strength, and balance in cognitively impaired older adults.4 Emerging evidence strongly supports the inclusion of motor function assessments, particularly gait analysis, in the early detection and risk stratification of AD.
- Advanced MRI techniques, such as diffusion tensor imaging (DTI), are used to assess white matter integrity along motor pathways, while molecular PET imaging can visualize amyloid and tau pathology in brain regions associated with motor control.7 Of note, tau pathology in higher motor regions has been significantly associated with cognitive decline.
- Improving mobility, balance, and functional independence may result in greater patients' autonomy and reduced physical and emotional strain on caregivers.
Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 57/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 33 of the 58 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Psychiatrike = Psychiatriki) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40400272) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 33 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 33 of the 58 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
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