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Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease
Hu WT, Ozturk T, Kollhoff A, Wharton W, Christina Howell J, Alzheimer’s Disease Neuroimaging Initiative.. Nature communications, 2021-06-28
Topic: Amyloid, tau and blood-test diagnosis
Neuroinflammation is associated with Alzheimer's disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 cerebrospinal proteins related to microglial and T-cell functions, and show them to reproducibly form functionally-related groups within and across diagnostic categories in 382 participants from the Alzheimer's Disease Neuro-imaging Initiative as well participants from two independent cohorts. We further show higher levels of proteins related to soluble tumor necrosis factor receptor 1 are associated with reduced risk of conversion to dementia in the multi-centered (p = 0.027) and independent (p = 0.038) cohorts of people with mild cognitive impairment due to predicted Alzheimer's disease, while higher soluble TREM2 levels associated with slower decline in the dementia stage of Alzheimer's disease. These inflammatory proteins thus provide prognostic information independent of established Alzheimer's markers.
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APA 7th
Hu, W. T., Ozturk, T., Kollhoff, A., Wharton, W., Christina Howell, J., & Alzheimer’s Disease Neuroimaging Initiative. (2021). Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease. Nature communications. https://doi.org/10.1038/s41467-021-24220-7
Vancouver
Hu WT, Ozturk T, Kollhoff A, Wharton W, Christina Howell J, Alzheimer’s Disease Neuroimaging Initiative. Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease. Nature communications. 2021. doi:10.1038/s41467-021-24220-7. PMID: 34183654.
BibTeX
@article{hu2021-34183654,
author = {Hu, W. T. and Ozturk, T. and Kollhoff, A. and Wharton, W. and Christina Howell, J. and {Alzheimer’s Disease Neuroimaging Initiative}},
title = {{Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease}},
journal = {Nature communications},
year = {2021},
doi = {10.1038/s41467-021-24220-7},
pmid = {34183654},
url = {https://doi.org/10.1038/s41467-021-24220-7}
}
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Key findings
- Neuroinflammation is associated with Alzheimer's disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them.
- We further show higher levels of proteins related to soluble tumor necrosis factor receptor 1 are associated with reduced risk of conversion to dementia in the multi-centered (p = 0.027) and independent (p = 0.038) cohorts of people with mild cognitive impairment due to predicted Alzheimer's disease, while higher soluble TREM2 levels associated with slower decline in the dementia stage of Alzheimer's disease.
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Study details
- Participants382
- Evidence strengthLow
How this study scored 55/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 32 of the 58 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Nature communications) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 382 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34183654) |
| Free to read | 2 / 2 | Free to read |
| Points | 32 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 32 of the 58 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
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