Home › Research › Digital health tools
Evolution of Parkinson's disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus
Østergaard K, Aa Sunde N.. Movement disorders : official journal of the Movement Disorder Society, 2006-05-01
Topic: Brain proteins, microglia and lab models
Plain-language summary
Patients with advanced Parkinson's disease (PD) and motor complications can obtain significant symptom improvement by deep brain stimulation (DBS) of the subthalamic nucleus (STN). Very little is published, however, about long-term effect and disease evolution during DBS. We performed a 4-year prospective study of the first 22 consecutive patients treated with STN DBS. The patients were evaluated with Unified Parkinson's Disease Rating Scale Part II to VI and a patient diary concerning on-off periods and dyskinesia. Patients were scored before surgery on medication and off medication for 10 to 12 hours and in four conditions 1 and 4 years after surgery: off medication+/-stimulation and on medication+/-stimulation. In advanced PD, a significant reduction of dyskinesia and off periods was present 4 years (90%/67%) after the operation. Total motor function on stimulation alone improved 55% at 4 years, compared with baseline and activities of daily living (42%). On stimulation, significant worsening of axial symptoms and speech was present from 1 to 4 years. To evaluate disease evolution, motor symptoms were assessed off stimulation and medication for 12 hours and were found not to worsen compared with baseline, which is remarkable in an otherwise progressive disorder. Five patients developed dementia. Severe adverse events were not observed.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Østergaard, K., & Aa Sunde, N. (2006). Evolution of Parkinson's disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus. Movement disorders : official journal of the Movement Disorder Society. https://doi.org/10.1002/mds.20776
Vancouver
Østergaard K, Aa Sunde N. Evolution of Parkinson's disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus. Movement disorders : official journal of the Movement Disorder Society. 2006. doi:10.1002/mds.20776. PMID: 16283616.
BibTeX
@article{ostergaard2006-16283616,
author = {Østergaard, K. and Aa Sunde, N.},
title = {{Evolution of Parkinson's disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus}},
journal = {Movement disorders : official journal of the Movement Disorder Society},
year = {2006},
doi = {10.1002/mds.20776},
pmid = {16283616},
url = {https://doi.org/10.1002/mds.20776}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Patients with advanced Parkinson's disease (PD) and motor complications can obtain significant symptom improvement by deep brain stimulation (DBS) of the subthalamic nucleus (STN).
- In advanced PD, a significant reduction of dyskinesia and off periods was present 4 years (90%/67%) after the operation.
- Total motor function on stimulation alone improved 55% at 4 years, compared with baseline and activities of daily living (42%).
- On stimulation, significant worsening of axial symptoms and speech was present from 1 to 4 years.
- To evaluate disease evolution, motor symptoms were assessed off stimulation and medication for 12 hours and were found not to worsen compared with baseline, which is remarkable in an otherwise progressive disorder.
Why it matters
In 22 Parkinson's disease patients with 4 years of bilateral subthalamic nucleus deep brain stimulation, dyskinesia and off periods were reduced and motor function improved, but axial symptoms and speech worsened from 1 to 4 years and five patients developed dementia. This concerns Parkinson's disease symptom management, not treating, curing, or preventing Alzheimer's disease.
New to this subject? Start with our plain-English guide: Digital health →
Study details
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 36 of the 96 points we could judge it on, which is 38 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Movement disorders : official journal of the Movement Disorder Society) |
| Journal's citation record | 3 / 4 | Movement Disorders: journal h-index 281 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 171 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.8 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 3 / 6 | Cited 6.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author Niels Aa. Sunde holds only 8 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 1 / 3 | Aarhus University Hospital: institution h-index 776 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16283616) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 36 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 36 of the 96 points we could judge it on is 38 out of 100. |
| Total | 38 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Related
Studies in the library that share something with this one. The line above each title says what.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Related studies in Digital health tools from nearby years
Also tagged “lewy”
1,017 studies in the library carry the topic tag “lewy”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,017 tagged studies.