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46/100

✓ Peer-reviewed alzhub usefulness score 46 out of 100. TREM2 and immune genetics

Topic: Brain proteins, microglia and lab models

Background Microglia, the brain's principal immune cells, have been implicated in the pathogenesis of Alzheimer's disease (AD), a condition shown to affect more females than males. Although sex differences in microglial function and transcriptomic programming have been described across development and in disease models of AD, no studies have comprehensively identified the sex divergences that emerge in the aging mouse hippocampus. Further, existing models of AD generally develop pathology (amyloid plaques and tau tangles) early in life and fail to recapitulate the aged brain environment associated with late-onset AD.

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APA 7th

Ocañas, SR., Pham, K. D., Cox, J. E. J., Keck, A. W., Ko, S., Ampadu, F. A., et al. (2023). Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease. Journal of neuroinflammation. https://doi.org/10.1186/s12974-023-02870-2

Vancouver

Ocañas SR, Pham KD, Cox JEJ, Keck AW, Ko S, Ampadu FA, et al. Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease. Journal of neuroinflammation. 2023. doi:10.1186/s12974-023-02870-2. PMID: 37587511.

BibTeX

@article{ocanas2023-37587511,
  author  = {Ocañas, SR. and Pham, K. D. and Cox, J. E. J. and Keck, A. W. and Ko, S. and Ampadu, F. A. and Porter, H. L. and Ansere, V. A. and others},
  title   = {{Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2023},
  doi     = {10.1186/s12974-023-02870-2},
  pmid    = {37587511},
  url     = {https://doi.org/10.1186/s12974-023-02870-2}
}

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Key findings

Although sex differences in microglial function and transcriptomic programming have been described across development and in disease models of AD, no studies have comprehensively identified the sex divergences that emerge in the aging mouse hippocampus.
Further, existing models of AD generally develop pathology (amyloid plaques and tau tangles) early in life and fail to recapitulate the aged brain environment associated with late-onset AD.
Here, we examined and compared transcriptomic and translatomic sex effects in young and old murine hippocampal microglia.
Methods Hippocampal tissue from C57BL6/N and microglial NuTRAP mice of both sexes were collected at young (5-6 month-old [mo]) and old (22-25 mo) ages.

Why it matters

In aging mouse hippocampus, this study found female-biased neuroinflammation and microglial senescence. This is early animal work on aging and sex differences and does not show that any treatment prevents or cures Alzheimer's disease in people.

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Study details

Evidence strengthLow

How this study scored 46/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of neuroinflammation)
Journal's citation record	2 / 4	Journal of Neuroinflammation: journal h-index 216 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2023 — within 6 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Laboratory or animal study (title names “mouse”) — scores zero
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 79 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	15.8 citations a year over 5 year(s) since 2023
Impact for its field and year	3 / 6	Cited 6.8× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 4 other studies in this library
Still being cited	3 / 4	Cited 75 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Willard M. Freeman: h-index 51 (OpenAlex, whole career)
Institution's track record	0 / 3	University of Oklahoma Health Sciences Center: institution h-index 557 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 37587511)
Free to read	2 / 2	Free to read
Total	46 / 100	—

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