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Treatment of advanced Parkinson's disease
Varanese S, Birnbaum Z, Rossi R, Di Rocco A.. Parkinson's disease, 2011-02-07
Topic: Amyloid, tau and blood-test diagnosis
Patients at late stage Parkinson's disease (PD) develop several motor and nonmotor complications, which dramatically impair their quality of life. These complications include motor fluctuations, dyskinesia, unpredictable or absent response to medications, falls, dysautonomia, dementia, hallucinations, sleep disorders, depression, and psychosis. The therapeutic management should be driven by the attempt to create a balance between benefit and side effects of the pharmacological treatments available. Supportive care, including physical and rehabilitative interventions, speech therapy, occupational therapy, and nursing care, has a key role in the late stage of disease. In this review we discuss the several complications experienced by advance PD patients and their management. The importance of an integrative approach, including both pharmacological and supportive interventions, is emphasized.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Varanese, S., Birnbaum, Z., Rossi, R., & Di Rocco, A. (2011). Treatment of advanced Parkinson's disease. Parkinson's disease. https://doi.org/10.4061/2010/480260
Vancouver
Varanese S, Birnbaum Z, Rossi R, Di Rocco A. Treatment of advanced Parkinson's disease. Parkinson's disease. 2011. doi:10.4061/2010/480260. PMID: 21331376.
BibTeX
@article{varanese2011-21331376,
author = {Varanese, S. and Birnbaum, Z. and Rossi, R. and Di Rocco, A.},
title = {{Treatment of advanced Parkinson's disease}},
journal = {Parkinson's disease},
year = {2011},
doi = {10.4061/2010/480260},
pmid = {21331376},
url = {https://doi.org/10.4061/2010/480260}
}
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Key findings
- These complications include motor fluctuations, dyskinesia, unpredictable or absent response to medications, falls, dysautonomia, dementia, hallucinations, sleep disorders, depression, and psychosis.
- The therapeutic management should be driven by the attempt to create a balance between benefit and side effects of the pharmacological treatments available.
- Supportive care, including physical and rehabilitative interventions, speech therapy, occupational therapy, and nursing care, has a key role in the late stage of disease.
- In this review we discuss the several complications experienced by advance PD patients and their management.
- The importance of an integrative approach, including both pharmacological and supportive interventions, is emphasized.
Why it matters
This review discusses treatment of advanced Parkinson's disease, including dementia as one complication, and emphasizes balancing pharmacological benefits and side effects. It is about Parkinson's disease management, not about treating, curing or preventing Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 37/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Parkinson's disease) |
| Journal's citation record | 0 / 4 | Parkinson s Disease: journal h-index 73 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 98 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.8 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 2 / 6 | Cited 1.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Alessandro Di Rocco: h-index 36 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | New York University: institution h-index 1,612 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21331376) |
| Free to read | 2 / 2 | Free to read |
| Total | 37 / 100 | — |
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Read the original
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