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Blood-brain barrier integrity disruption is associated with both chronic vascular risk factors and white matter hyperintensities
James Xiao Yuan Chen, Ashwati Vipin, Gurveen Kaur Sandhu, Yi Jin Leow, Fatin Zahra Zailan, Pricilia Tanoto, Ee Soo Lee, Khang Leng Lee et al.. The Journal of Prevention of Alzheimer s Disease, 2025-01-23
Topic: Brain proteins, microglia and lab models
Plasma from individuals with a higher WMH burden was associated with increased BBB disruption in hBMEC. Higher systolic and diastolic blood pressure, as well as body mass index, were correlated with greater BBB disruption. Regression analyses revealed that elevated blood glucose and lipid levels were linked to increased BBB disruption. Both periventricular and subcortical WMH burdens were associated with increased BBB disruption. This study highlights a relationship between CRFs, BBB disruption, and WMH burden, suggesting that CRFs may impair BBB integrity and contribute to WMH and cognitive decline in cSVD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Chen, J. X. Y., Vipin, A., Sandhu, G. K., Leow, Y. J., Zailan, F. Z., Tanoto, P., et al. (2025). Blood-brain barrier integrity disruption is associated with both chronic vascular risk factors and white matter hyperintensities. The Journal of Prevention of Alzheimer s Disease. https://doi.org/10.1016/j.tjpad.2024.100029
Vancouver
Chen JXY, Vipin A, Sandhu GK, Leow YJ, Zailan FZ, Tanoto P, et al. Blood-brain barrier integrity disruption is associated with both chronic vascular risk factors and white matter hyperintensities. The Journal of Prevention of Alzheimer s Disease. 2025. doi:10.1016/j.tjpad.2024.100029. PMID: 39863325.
BibTeX
@article{chen2025-39863325,
author = {Chen, James Xiao Yuan and Vipin, Ashwati and Sandhu, Gurveen Kaur and Leow, Yi Jin and Zailan, Fatin Zahra and Tanoto, Pricilia and Lee, Ee Soo and Lee, Khang Leng and others},
title = {{Blood-brain barrier integrity disruption is associated with both chronic vascular risk factors and white matter hyperintensities}},
journal = {The Journal of Prevention of Alzheimer s Disease},
year = {2025},
doi = {10.1016/j.tjpad.2024.100029},
pmid = {39863325},
url = {https://doi.org/10.1016/j.tjpad.2024.100029}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Plasma from individuals with a higher WMH burden was associated with increased BBB disruption in hBMEC.
- Higher systolic and diastolic blood pressure, as well as body mass index, were correlated with greater BBB disruption.
- Regression analyses revealed that elevated blood glucose and lipid levels were linked to increased BBB disruption.
- Both periventricular and subcortical WMH burdens were associated with increased BBB disruption.
- This study highlights a relationship between CRFs, BBB disruption, and WMH burden, suggesting that CRFs may impair BBB integrity and contribute to WMH and cognitive decline in cSVD.
Why it matters
This study found that plasma from people with more white matter hyperintensities caused more blood-brain barrier disruption in cells, and that higher blood pressure, body mass index, blood glucose and lipid levels were linked to greater disruption. It suggests chronic vascular risk factors may impair the blood-brain barrier and contribute to white matter damage and cognitive decline in small vessel disease.
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Study details
- Participants155
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Journal of Prevention of Alzheimer s Disease) |
| Journal's citation record | 0 / 4 | The Journal of Prevention of Alzheimer s Disease: journal h-index 63 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 155 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 21 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 6.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 21 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Nagaendran Kandiah: h-index 45 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Nanyang Technological University: institution h-index 981 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39863325) |
| Free to read | 2 / 2 | Free to read |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.tjpad.2024.100029
- PubMed: 39863325
- Original source →
- Free full text: The Journal of Prevention of Alzheimer s Disease →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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