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MIND diet and the risk of dementia: a population-based study
de Crom TOE, Mooldijk SS, Ikram MK, Ikram MA, Voortman T.. Alzheimer's research & therapy, 2022-01-12
Topic: Risk, prevention and care in population studies
Background Adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet has been linked to a decreased risk of dementia, but reverse causality and residual confounding by lifestyle may partly account for this link. We aimed to address these issues by studying the associations over cumulative time periods, which may provide insight into possible reverse causality, and by using both historical and more contemporary dietary data as this could give insight into confounding since historical data may be less affected by lifestyle factors. Methods In the population-based Rotterdam Study, dietary intake was assessed using validated food frequency questionnaires in 5375 participants between 1989 and 1993 (baseline I) and in a largely non-overlapping sample in 2861 participants between 2009 and 2013 (baseline II).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
de Crom, T. O. E., Mooldijk, S. S., Ikram, M. K., Ikram, M. A., & Voortman, T. (2022). MIND diet and the risk of dementia: a population-based study. Alzheimer's research & therapy. https://doi.org/10.1186/s13195-022-00957-1
Vancouver
de Crom TOE, Mooldijk SS, Ikram MK, Ikram MA, Voortman T. MIND diet and the risk of dementia: a population-based study. Alzheimer's research & therapy. 2022. doi:10.1186/s13195-022-00957-1. PMID: 35022067.
BibTeX
@article{decrom2022-35022067,
author = {de Crom, T. O. E. and Mooldijk, S. S. and Ikram, M. K. and Ikram, M. A. and Voortman, T.},
title = {{MIND diet and the risk of dementia: a population-based study}},
journal = {Alzheimer's research \& therapy},
year = {2022},
doi = {10.1186/s13195-022-00957-1},
pmid = {35022067},
url = {https://doi.org/10.1186/s13195-022-00957-1}
}
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Key findings
- We aimed to address these issues by studying the associations over cumulative time periods, which may provide insight into possible reverse causality, and by using both historical and more contemporary dietary data as this could give insight into confounding since historical data may be less affected by lifestyle factors.
- Methods In the population-based Rotterdam Study, dietary intake was assessed using validated food frequency questionnaires in 5375 participants between 1989 and 1993 (baseline I) and in a largely non-overlapping sample in 2861 participants between 2009 and 2013 (baseline II).
- We calculated the MIND diet score and studied its association with the risk of all-cause dementia, using Cox models.
- Incident all-cause dementia was recorded until 2018.
Why it matters
This study examined whether the MIND diet is linked to lower dementia risk while trying to account for reverse causality and lifestyle confounding. It does not establish that following the MIND diet prevents dementia, and the findings are about associations in a population study.
Study details
- Participants5,375
- Evidence strengthLow
How this study scored 53/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer's research & therapy) |
| Journal's citation record | 1 / 4 | Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 3 / 4 | 5,375 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 94 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 15.7 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 4 / 6 | Cited 16.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 3 / 4 | Cited 66 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Trudy Voortman: h-index 61 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35022067) |
| Free to read | 2 / 2 | Free to read |
| Total | 53 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s13195-022-00957-1
- PubMed: 35022067
- Original source →
- Free full text: Alzheimer s Research & Therapy →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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