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Association of small vessel disease progression with longitudinal cognitive decline across mild cognitive impairment
Jingru Wang, Asta Debora, Lixuan Chen, Haisong Chen, Xuemiao Zhao, Mengying Yu, Yunjun Yang, for the Alzheimer's Disease Neuroimaging Initiative. Journal of Alzheimer s Disease, 2025-01-10
Topic: Risk, prevention and care in population studies
In the CN group, cerebral microbleed (CMB) progression was associated with the decline in language function (p < 0.05), and deep white matter hyperintensity (WMH) progression was associated with a decline in memory function (p < 0.05). In the MCI group, CMB progression was associated with a decline in memory function (p < 0.05) and lacunes progression was associated with executive function (p < 0.05), whereas the progression of global SVD score was not related to longitudinal cognitive function. The progression of CMB and WMH had an impact on cognitive decline in both CN and MCI groups, and lacunes progression only had an association with cognitive decline in the MCI group. Our study suggested that individual SVD markers may have a higher predictive value in longitudinal cognition compared with global SVD burden.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wang, J., Debora, A., Chen, L., Chen, H., Zhao, X., Yu, M., et al. (2025). Association of small vessel disease progression with longitudinal cognitive decline across mild cognitive impairment. Journal of Alzheimer s Disease. https://doi.org/10.1177/13872877241305800
Vancouver
Wang J, Debora A, Chen L, Chen H, Zhao X, Yu M, et al. Association of small vessel disease progression with longitudinal cognitive decline across mild cognitive impairment. Journal of Alzheimer s Disease. 2025. doi:10.1177/13872877241305800. PMID: 39791370.
BibTeX
@article{wang2025-39791370,
author = {Wang, Jingru and Debora, Asta and Chen, Lixuan and Chen, Haisong and Zhao, Xuemiao and Yu, Mengying and Yang, Yunjun and {Alzheimer's Disease Neuroimaging Initiative}},
title = {{Association of small vessel disease progression with longitudinal cognitive decline across mild cognitive impairment}},
journal = {Journal of Alzheimer s Disease},
year = {2025},
doi = {10.1177/13872877241305800},
pmid = {39791370},
url = {https://doi.org/10.1177/13872877241305800}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- In the CN group, cerebral microbleed (CMB) progression was associated with the decline in language function (p < 0.05), and deep white matter hyperintensity (WMH) progression was associated with a decline in memory function (p < 0.05).
- In the MCI group, CMB progression was associated with a decline in memory function (p < 0.05) and lacunes progression was associated with executive function (p < 0.05), whereas the progression of global SVD score was not related to longitudinal cognitive function.
- The progression of CMB and WMH had an impact on cognitive decline in both CN and MCI groups, and lacunes progression only had an association with cognitive decline in the MCI group.
- Our study suggested that individual SVD markers may have a higher predictive value in longitudinal cognition compared with global SVD burden.
Why it matters
This longitudinal study found that progression of individual small vessel disease markers, such as cerebral microbleeds and white matter hyperintensities, was linked to declines in specific cognitive functions in both cognitively normal and mild cognitive impairment groups. It suggests that tracking individual markers may be more useful than a global score for predicting cognitive decline, but it does not test any treatment or prevention.
Study details
- Study designlongitudinal study
- Participants432
- Evidence strengthModerate
How this study scored 45/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 43 of the 96 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer s Disease) |
| Journal's citation record | 2 / 4 | Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 432 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 0 / 3 | First Affiliated Hospital of Wenzhou Medical University: institution h-index 263 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39791370) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 43 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 43 of the 96 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
What each of these 20 components measures, and what this score is not →
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