EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease
Ponomareva NV, Korovaitseva GI, Rogaev EI.. Neurobiology of aging, 2007-02-12
Topic: Amyloid, tau and blood-test diagnosis
Plain-language summary
Identification of preclinical markers is required for early diagnosis of Alzheimer's disease (AD) and cognitive dysfunction in advancing age. Quantitative EEG was examined in 145 individuals with AD, their unaffected relatives and unrelated individuals. The AD patients and their relatives were stratified by ApoE genotype. The resting EEG parameters were severely changed in AD patients, and in patients carrying the ApoE epsilon4 allele the decrease in alpha power was higher than in epsilon4 non-carriers. The resting EEG parameters were indistinguishable in AD relatives with different ApoE genotypes and similar to EEG pattern in common population. Under hyperventilation the presence of the epsilon4 allele in AD relatives was associated with the manifestation of synchronous high-voltage delta-, theta-activity and sharp-waves, pronounced decrease in alpha and increase in delta and theta relative powers. The data suggest that neurophysiological endophenotype of non-demented individuals at genetic risk for AD, characterized by increased excitability and dysfunction of deep brain and alpha rhythm-generating structures, may be revealed decades before the first clinical symptoms of presumable dementia.
What this study adds
Evidence grade: Low
The record lists 145 participants. In non-demented relatives of Alzheimer disease patients, carrying the APOE ε4 allele was associated with abnormal EEG patterns during hyperventilation, which the authors suggest may appear decades before symptoms. This is a preliminary physiological finding and does not show that any treatment can delay dementia.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ponomareva, N. V., Korovaitseva, G. I., & Rogaev, E. I. (2008). EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2006.12.019
Vancouver
Ponomareva NV, Korovaitseva GI, Rogaev EI. EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease. Neurobiology of aging. 2008. doi:10.1016/j.neurobiolaging.2006.12.019. PMID: 17293007.
BibTeX
@article{ponomareva2008-17293007,
author = {Ponomareva, N. V. and Korovaitseva, G. I. and Rogaev, E. I.},
title = {{EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease}},
journal = {Neurobiology of aging},
year = {2008},
doi = {10.1016/j.neurobiolaging.2006.12.019},
pmid = {17293007},
url = {https://doi.org/10.1016/j.neurobiolaging.2006.12.019}
}
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Key findings
- Under hyperventilation the presence of the epsilon4 allele in AD relatives was associated with the manifestation of synchronous high-voltage delta-, theta-activity and sharp-waves, pronounced decrease in alpha and increase in delta and theta relative powers.
- The data suggest that neurophysiological endophenotype of non-demented individuals at genetic risk for AD, characterized by increased excitability and dysfunction of deep brain and alpha rhythm-generating structures, may be revealed decades before the first clinical symptoms of presumable dementia.
Why it matters
In non-demented relatives of Alzheimer disease patients, carrying the APOE ε4 allele was associated with abnormal EEG patterns during hyperventilation, which the authors suggest may appear decades before symptoms. This is a preliminary physiological finding and does not show that any treatment can delay dementia.
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Study details
- Participants145
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | 3 / 4 | Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2008 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 145 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 94 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.7 citations a year over 20 year(s) since 2008 |
| Impact for its field and year | 3 / 6 | Cited 3.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 2 / 4 | Cited 15 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Evgeny Ivanovich Rogaev: h-index 49 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Massachusetts Chan Medical School: institution h-index 990 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17293007) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 45 / 100 | — |
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