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A head-to-head comparison of plasma biomarkers to detect biologically defined Alzheimer in a memory clinic
Anastasi F, Fernández-Lebrero A, Ashton NJ, Ortiz-Romero P, Torres-Torronteras J, González-Escalante A, Milà-Alomà M, Contador J et al.. medRxiv, 2024-10-27
Topic: Amyloid, tau and blood-test diagnosis
ABSTRACT INTRODUCTION Blood-based biomarkers for Alzheimer’s disease (AD) have been widely studied, but direct comparisons of several biomarkers in clinical settings remain limited. METHODS In this cross-sectional study, plasma biomarkers from 197 participants in the BIODEGMAR cohort at Hospital del Mar (Barcelona) were analysed. Participants were classified based on AD cerebrospinal fluid (CSF) core biomarkers.
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APA 7th
Anastasi, F., Fernández-Lebrero, A., Ashton, N. J., Ortiz-Romero, P., Torres-Torronteras, J., González-Escalante, A., et al. (2024). A head-to-head comparison of plasma biomarkers to detect biologically defined Alzheimer in a memory clinic. medRxiv. https://doi.org/10.1101/2024.10.26.24316176
Vancouver
Anastasi F, Fernández-Lebrero A, Ashton NJ, Ortiz-Romero P, Torres-Torronteras J, González-Escalante A, et al. A head-to-head comparison of plasma biomarkers to detect biologically defined Alzheimer in a memory clinic. medRxiv. 2024. doi:10.1101/2024.10.26.24316176.
BibTeX
@article{anastasi2024-0d19a4a8,
author = {Anastasi, F. and Fernández-Lebrero, A. and Ashton, N. J. and Ortiz-Romero, P. and Torres-Torronteras, J. and González-Escalante, A. and Milà-Alomà, M. and Contador, J. and others},
title = {{A head-to-head comparison of plasma biomarkers to detect biologically defined Alzheimer in a memory clinic}},
journal = {medRxiv},
year = {2024},
doi = {10.1101/2024.10.26.24316176},
url = {https://doi.org/10.1101/2024.10.26.24316176}
}
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Key findings
- METHODS In this cross-sectional study, plasma biomarkers from 197 participants in the BIODEGMAR cohort at Hospital del Mar (Barcelona) were analysed.
- Participants were classified based on AD cerebrospinal fluid (CSF) core biomarkers.
- We assessed the ability of plasma p-tau181, p-tau217, p-tau231, t-tau, and Aβ42/40 to classify Aβ status.
- RESULTS Plasma p-tau biomarkers had a greater diagnostic performance and larger effect sizes compared to t-tau and Aβ42/40 assays in detecting biologically defined AD.
Why it matters
In this cross-sectional memory clinic study, plasma p-tau biomarkers had greater diagnostic performance and larger effect sizes than t-tau and Aβ42/40 assays for detecting biologically defined Alzheimer's disease. It is about diagnosis only and says nothing about treating, curing or preventing the disease.
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Study details
- Study designcross-sectional
- Participants197
- Evidence strengthModerate
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 35 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for effect reported and randomized / blinded because the record does not state it. We have no data on impact for its field and year, so that was left out: it earned 33 of the 94 points we could judge it on, which is 35 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (medRxiv) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 197 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.5 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Marc Suárez‐Calvet: h-index 59 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, San Francisco: institution h-index 1,915 (OpenAlex) |
| Multicenter collaboration | 3 / 3 | OpenAlex lists 22 institution(s) in 7 countries |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 33 / 94 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 33 of the 94 points we could judge it on is 35 out of 100. |
| Total | 35 / 100 | Capped to 16 because this is not a peer-reviewed article. |
What each of these 20 components measures, and what this score is not →
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