This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

32/100

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Disease mechanisms

Topic: Brain proteins, microglia and lab models

Semantic dementia (SD) is a type of dementia characterized by a loss of semantic memory, typically presenting with left-predominant temporal lobe atrophy and a frontotemporal lobar degeneration with TDP-43 (FTLD-TDP) type C pathology. However, atypical variants, such as those with a late-onset or right-predominant atrophy, exhibit considerable pathological diversity. We report an 81-year-old woman with atypical SD who presented with impaired naming, mild word comprehension deficits, and prosopagnosia. Brain MRI revealed right-predominant atrophy in the amygdala, hippocampus, and anterior temporal lobes. Cerebrospinal fluid analysis showed a normal Aβ level, suggesting a non-Alzheimer's disease pathology. Tau PET imaging demonstrated a high signal in the right anterior temporal lobe, consistent with primary tauopathy. The patient's clinical presentation and imaging findings, particularly the atrophy in the amygdala and hippocampus, as well as the preserved communication ability, raised the possibility of argyrophilic grain disease (AGD) as the underlying pathology. This case highlights the importance of molecular imaging in diagnosing atypical SD. It suggests that AGD should be considered a possible underlying pathology for atypical SD cases, particularly those with late onset and right-sided predominance. A longer follow-up and eventual autopsy would be necessary to confirm the pathological diagnosis.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Sudo, Y., Tamura, M., Nakayama, K., Nemoto, K., Yokota, O., Tagai, K., et al. (2025). A Case of Late‐Onset Semantic Dementia With Right‐Predominant Temporal Lobe Atrophy due to Primary Tauopathy. Psychogeriatrics. https://doi.org/10.1111/psyg.70094

Vancouver

Sudo Y, Tamura M, Nakayama K, Nemoto K, Yokota O, Tagai K, et al. A Case of Late‐Onset Semantic Dementia With Right‐Predominant Temporal Lobe Atrophy due to Primary Tauopathy. Psychogeriatrics. 2025. doi:10.1111/psyg.70094. PMID: 40946722.

BibTeX

@article{sudo2025-40946722,
  author  = {Sudo, Yuta and Tamura, Motoshi and Nakayama, Kenjiro and Nemoto, Kiyotaka and Yokota, Osamu and Tagai, Kenji and Endo, Hironobu and Tokuda, Takahiko and others},
  title   = {{A Case of Late‐Onset Semantic Dementia With Right‐Predominant Temporal Lobe Atrophy due to Primary Tauopathy}},
  journal = {Psychogeriatrics},
  year    = {2025},
  doi     = {10.1111/psyg.70094},
  pmid    = {40946722},
  url     = {https://doi.org/10.1111/psyg.70094}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

Key findings

Brain MRI revealed right-predominant atrophy in the amygdala, hippocampus, and anterior temporal lobes.
Tau PET imaging demonstrated a high signal in the right anterior temporal lobe, consistent with primary tauopathy.
It suggests that AGD should be considered a possible underlying pathology for atypical SD cases, particularly those with late onset and right-sided predominance.

Why it matters

This single case report describes an 81-year-old woman with atypical semantic dementia whose imaging suggested a primary tauopathy, possibly argyrophilic grain disease. It is one patient's case and cannot establish any treatment, cure or prevention for Alzheimer's disease.

Study details

Evidence strengthLow

How this study scored 32/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Psychogeriatrics)
Journal's citation record	0 / 4	Psychogeriatrics: journal h-index 62 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Tetsuaki Arai: h-index 55 (OpenAlex, whole career)
Institution's track record	1 / 3	The University of Osaka: institution h-index 1,138 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40946722)
Free to read	2 / 2	Free to read
Total	32 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies in the library that share something with this one. The line above each title says what.

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here.

Related studies in Disease mechanisms

Also tagged “phosphorylated”

733 studies in the library carry the topic tag “phosphorylated”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 733 tagged studies.

Studies sharing this one's topic tags

Similar studies

More on Disease mechanisms

See all studies in Disease mechanisms →