31,780 Alzheimer's and dementia studies in plain English, each scored out of 100.
Greater adherence to a Mediterranean diet is associated with a significant improvement in health status, as seen by a significant reduction in overall mortality (9%), mortality from cardiovascular diseases (9%), incidence of or mortality from cancer (6%), and incidence of Parkinson's disease and Alzheimer's disease (13%). 3 key findings →
Design: meta-analysis Participants: 574,299 Evidence: high
Full summary, score breakdown and related studies → Original source
A total of 45 reviews with 212 meta-analyses were synthesized. 5 key findings →
Design: meta-analysis Participants: 45 Evidence: high
Full summary, score breakdown and related studies → Original source
Forty-five studies involving over 730 000 participants were included. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
Increased absolute sugar intake (g/day) was significantly associated with a higher risk of all-cause dementia (HR = 1.003, [95%CI: 1.002-1.004], p < 0.001) and Alzheimer's disease (1.002, [1.001-1.004], 0.005). 5 key findings →
Design: cohort study Participants: 210,832 Evidence: moderate
Full summary, score breakdown and related studies → Original source
The results show that the western diet pattern is a risk factor for developing AD. 5 key findings →
Design: systematic review Participants: 38 Evidence: high
Full summary, score breakdown and related studies → Original source
We searched 122 studies, of which 90 were included in our analysis. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
The search over five databases identified 898 articles, with 26 meeting the inclusion criteria. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
176 and 131 participants developed incident frailty, as measured with the FI and TFI respectively. 5 key findings →
Design: longitudinal study Participants: 131 Evidence: moderate
Full summary, score breakdown and related studies → Original source
A high-protein and alcohol dietary pattern was negatively associated with cortical thickness in the whole brain (Beta: -0.011; 95% confidence interval [CI]: -0.018 to -0.003), and with an Alzheimer's disease cortical thickness signature score (Beta: -0.013; 95% CI: -0.024 to -0.001). 5 key findings →
Design: cohort study Participants: 610 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Emerging evidence of brain injury on risk of neurodegenerative diseases such as Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE) have resulted in interest in therapeutic potential of omega-3 fatty acids (n-3FA). 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
The search generated 33 papers, which yielded 11 articles after screening. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
A reduction in the incidence of smoking will likely reduce the future prevalence of AD. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
To examine the relationship between smoking and Alzheimer's disease (AD) after controlling for study design, quality, secular trend, and tobacco industry affiliation of the authors, electronic databases were searched; 43 individual studies met the inclusion criteria. 4 key findings →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
RECENT FINDINGS: Based on available epidemiological studies, two meta-analyses published in 2013 have underlined a protective effect of a greater MeDi adherence on cognitive health, including a reduced risk of Alzheimer's disease and cognitive impairment. 2 key findings →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
We reviewed epidemiological and experimental studies of female gonadal hormone replacement therapy (HRT) on cognitive function in post-menopausal women and carried out meta-analyses. 1 key finding →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
A case-control study was performed to determine the possible roles of various environmental factors, prior illnesses, drug use, and personal habits in the development of Alzheimer's disease. 4 key findings →
Design: case-control study Participants: 40 Evidence: moderate
Full summary, score breakdown and related studies → Original source
53.0% of the participants were in the group of possible mild cognitive impairment (MCI). 5 key findings →
Design: cross-sectional Participants: 117 Evidence: moderate
Full summary, score breakdown and related studies → Original source
There were interactions between the dietary patterns and APOE ε4 status in relation to incident dementia (interaction p value threshold of < 0.1), while no evidence of interactions were found between the dietary patterns and the AD-PRSs. 4 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Diagnosis of AD was associated inversely with FTI by itself and after adjustments for age, education, smoking status, body mass index, diabetes, any cancer diagnoses, and hormone supplements. 5 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source
A total of 774 incident dementia cases were diagnosed and validated, of which 518 were Alzheimer's disease (AD). 5 key findings →
Participants: 25,015 Evidence: moderate
Full summary, score breakdown and related studies → Original source
There is substantial evidence supporting the neuroprotective effects of the MIND diet in neurodegenerative diseases like Parkinson's and Alzheimer's. Our aim was to evaluate the impact of a nutritional intervention (NI) with this diet on multiple sclerosis (MS) patients. 1 key finding →
Design: case-control study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory and mood. 2 key findings →
Participants: 371 Evidence: moderate
Full summary, score breakdown and related studies → Original source
A total of 260 AD deaths occurred during a median follow-up of 9.8 years. 5 key findings →
Participants: 27,773 Evidence: low
Full summary, score breakdown and related studies → Original source
Due to the continuous aging of the population and consequent increase in dementia, focus on its prevention is of growing importance for public health. 4 key findings →
Participants: 73 Evidence: low
Full summary, score breakdown and related studies → Original source
The main form of vitamin D in all brain regions measured was 25(OH)D3 . 5 key findings →
Participants: 290 Evidence: low
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 31,780 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 31,780 records, built mostly from automated pulls of Europe PMC (66% of the library) and OpenAlex (16%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,052 records (3.3% of the library) are not peer-reviewed — 973 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →
Newest studies, as a dated timeline → Atom feed Where this research is being discussed: events