Many survivors of breast cancer show significant cognitive impairments, including memory deficits. 5 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source
Research
31,780 Alzheimer's and dementia studies in plain English, each scored out of 100.
These data show that smaller hippocampal volumes are present from the onset of illness. 5 key findings →
Participants: 46 Evidence: low
Full summary, score breakdown and related studies → Original source
Maternal separation and poor maternal care in animals have been shown to have important effects on the developing hippocampus and amygdala. 5 key findings →
Participants: 17 Evidence: low
Full summary, score breakdown and related studies → Original source
Magnetic resonance imaging was used to quantify the volume of the hippocampus in 47 men with chronic alcoholism and 72 healthy male control subjects. 4 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source
In major depression, decreased hippocampal volume has been attributed to hypercortisolemia, a frequent sign of the disorder, because in animals an excess of corticosteroids has led to dendritic atrophy, astrogliosis and loss of neurons in this brain region. 1 key finding →
Participants: 15 Evidence: low
Full summary, score breakdown and related studies → Original source
The automated hippocampal volumetric methods showed good agreement with manual hippocampal volumetry, but the volume measured using FreeSurfer was 35% larger and the agreement was questionable with IBASPM. 3 key findings →
Participants: 21 Evidence: low
Full summary, score breakdown and related studies → Original source
Aberrations in hippocampal asymmetry and left hippocampal volumes were found for adolescent heavy drinkers. 5 key findings →
Participants: 16 Evidence: low
Full summary, score breakdown and related studies → Original source
Hypercortisolemia is a frequently observed abnormality in patients with major depression. 2 key findings →
Participants: 30 Evidence: low
Full summary, score breakdown and related studies → Original source
Compared with controls, relatives, particularly from multiplex families, had significantly smaller left hippocampi. 5 key findings →
Participants: 17 Evidence: low
Full summary, score breakdown and related studies → Original source
The present findings emphasize that patients with reduced hippocampal volumes show more executive dysfunctions than their counterparts. 2 key findings →
Participants: 34 Evidence: low
Full summary, score breakdown and related studies → Original source
Temporal lobe epilepsy (TLE) is considered primarily a limbic disorder. 2 key findings →
Participants: 68 Evidence: low
Full summary, score breakdown and related studies → Original source
Volumetric measures in a group of patients with traumatic brain injury who had received MR imaging 3 months or less after injury were compared with measurements in other patients in the chronic phase of recovery. 5 key findings →
Participants: 94 Evidence: low
Full summary, score breakdown and related studies → Original source
Patients with major depression may have structural abnormalities of the hippocampus that can be detected by analysis of hippocampal shape but not volume. 2 key findings →
Participants: 27 Evidence: low
Full summary, score breakdown and related studies → Original source
43/100
Hippocampal volume, while disproportionately small for brain size in individuals with Down's syndrome, remains fairly constant through the fifth decade of life in those without dementia. 4 key findings →
Participants: 25 Evidence: low
Full summary, score breakdown and related studies → Original source
Hippocampal atrophy is not only a characteristic of Alzheimer's disease but also occurs in FTLD. 5 key findings →
Participants: 42 Evidence: low
Full summary, score breakdown and related studies → Original source
This study compared a fornix cross-sectional-area measurement and hippocampal volume in 86 traumatic brain injury (TBI) subjects with 46 normal controls. 3 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source
Atrophy of the hippocampal formation, a region important for the acquisition of new declarative knowledge, has been well-documented in Alzheimer's disease (AD), although the relation of such atrophy to the extent of memory dysfunction in these patients has been less clear. 1 key finding →
Participants: 18 Evidence: low
Full summary, score breakdown and related studies → Original source
Smaller hippocampal volume is associated with psychiatric disorders. 3 key findings →
Participants: 44 Evidence: low
Full summary, score breakdown and related studies → Original source
Cognitive deficits in older adults attributable to Alzheimer's disease (AD) pathology are featured early on by hippocampal impairment. 3 key findings →
Participants: 23 Evidence: low
Full summary, score breakdown and related studies → Original source
Atrophy of hippocampus and alteration of resting eyes-closed electroencephalographic (EEG) rhythms represent important features of mild cognitive impairment (MCI) and Alzheimer's disease (AD). 4 key findings →
Participants: 40 Evidence: low
Full summary, score breakdown and related studies → Original source
The presence of a single APOE-epsilon4 allele is associated with an increased rate of hippocampal volume loss in healthy women in their sixth decade of life that is not related to any detectable memory changes. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Correction processes can define absolute hippocampal volumes for correlation studies and may enable identification of unsuspected bilateral hippocampal volume loss. 1 key finding →
Participants: 23 Evidence: low
Full summary, score breakdown and related studies → Original source
Participants with late-onset depression had bilateral hippocampal atrophy compared with those with early-onset depression and controls. 3 key findings →
Participants: 51 Evidence: low
Full summary, score breakdown and related studies → Original source
Measurement of regional abnormalities of HT2 along the length of the hippocampus provides further refinement to the MRI assessment of the hippocampi in patients with temporal lobe epilepsy and is complementary to volumetric and morphological data. 1 key finding →
Participants: 16 Evidence: low
Full summary, score breakdown and related studies → Original source
43/100
The pattern of thinning in TLE-no was different from the pattern in TLE-MTS. 3 key findings →
Participants: 66 Evidence: low
Full summary, score breakdown and related studies → Original source
From across this tag
10 of the 500 studies in this tag that have a study page, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline
- Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging
- Hippocampal cytogenesis correlates to escitalopram-mediated recovery in a chronic mild stress rat model of depression
- Western diet is associated with a smaller hippocampus: a longitudinal investigation
- Mapping subcortical brain maturation during adolescence: evidence of hemisphere- and sex-specific longitudinal changes
- Hippocampal atrophy in first episode depression: a meta-analysis of magnetic resonance imaging studies
- MRI Asymmetry Index of Hippocampal Subfields Increases Through the Continuum From the Mild Cognitive Impairment to the Alzheimer's Disease
- Regional specificity of hippocampal volume reductions in first-episode schizophrenia
- Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation
- Investigating structural brain changes of dehydration using voxel-based morphometry
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomized / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multicenter collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 31,780 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 31,780 records, built mostly from automated pulls of Europe PMC (66% of the library) and OpenAlex (16%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,052 records (3.3% of the library) are not peer-reviewed — 973 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →
Newest studies, as a dated timeline → Atom feed Where this research is being discussed: events