28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
Higher socioeconomic status and increased frequency of physical activity were associated with a lower risk of both EOD and LOD. 5 key findings →
Design: case-control study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Individuals with Alzheimer’s dementia exhibited poorer nutritional status (EdFED: 8.0 vs. 2.0; NUFFE: 10.0 vs. 7.0; both p < 0.001) and lower adherence to the Mediterranean diet (6.0 vs. 7.0; p = 0.050). 3 key findings →
Participants: 60 Evidence: low
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Patients in this study were from the China Stroke Center Alliance database. 5 key findings →
Evidence: low
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The relative risk of dementia following cerebral hemorrhage ( relative risk(RR):3.02[1.17-7.78],P<0.001 ) was higher than that of cerebral infarction (RR: 2.07[1.47-2.96], P<0.001). 5 key findings →
Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Sleep, sedentary behaviour, and physical activity (PA) are important for brain health. 4 key findings →
Participants: 1,899 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Diabetes is a major public health burden. 3 key findings →
Evidence: low
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Dementia and age-related macular degeneration (AMD) are major causes of disability in the elderly. n-3 Fatty acids, particularly docosahexaenoic acid (DHA), are highly concentrated in brain and retinal tissue and may prevent or delay the progression of dementia and AMD. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Dementia prevalence increases with age and Alzheimer's disease (AD) accounts for up to 75% of cases. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
14,292 patients were diagnosed with dementia over 2018–2021 (age 76.5+/−10.3 years; 53.1% female), with 96.3% linked to a census-tract-level ADI. 5 key findings →
Participants: 4,600 Evidence: low
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Dual-related differences were significantly larger than race/ethnicity differences in PAC transitions. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
BackgroundThere are limited studies quantifying the extent to which neighborhood deprivation affects mortality in individuals living with Alzheimer's disease (AD) and AD-related dementias (AD/ADRD).ObjectiveTo quantify to what extent neighborhood deprivation affects adverse outcomes in individuals living with AD/ADRD.MethodsWe identified individuals with AD/ADRD using a 15% random sample of national Medicare fee-for-service beneficiaries. 1 key finding →
Evidence: moderate
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We found declining dementia incidence but increasing dementia prevalence in a sample that includes the vast majority of older adults in the United States. 3 key findings →
Participants: 1,000 Evidence: moderate
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Age-related hearing loss (ARHL) has emerged as a significant and potentially modifiable risk factor for neurodegenerative disorders, including Alzheimer's disease. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Shorter telomeres were linked to stress, poor sleep, inflammation, and cardiometabolic markers. 5 key findings →
Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
• This analysis consists of 567 participants revealed that vitamin B12 deficiency, not folate or vitamin B1 deficiency was associated with hippocampal atrophy detected by MRI-VSRAD analysis. • Vitamin B12 deficiency was associated with hyperhomocysteinemia. • Clear correlations were observed between hippocampal atrophy and vitamin B12 value. 4 key findings →
Participants: 323 Evidence: low
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Recent advances in dementia research have expanded our understanding of modifiable risk factors, with air pollution being a well-established contributor. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
, respectively. standards in late life. https://doi.org/10.1289/EHP14723. 1 key finding →
Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Higher intakes of total sugar (HR = 1.292, 95 % CI = 1.148--1.453) and free sugar intake (HR = 1.254, 95 % CI = 1.117--1.408) were significantly associated with increased dementia risk. 4 key findings →
Participants: 172,516 Evidence: low
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During a median follow-up of 14.1 years, 279 early-onset dementia cases and 3167 late-onset dementia cases were documented. 5 key findings →
Participants: 249 Evidence: low
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all-cause mortality, stroke recurrence, cognition, and C-reactive protein (CRP). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
In the overall cohort (28 403 risperidone users and 136 324 mtatched controls), risperidone was associated with increased risk of stroke (adjusted hazard ratio: 1.28; 95% CI: 1.20-1.37). 5 key findings →
Evidence: moderate
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The association between poor cardiovascular health and cognitive decline as well as dementia progression has been inconsistent across studies. 4 key findings →
Evidence: low
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Human immunodeficiency virus-1 (HIV-1)-infected and immune-activated macrophages and microglia secrete neurotoxins. 4 key findings →
Evidence: low
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The study included 13,431 individuals diagnosed with dementia at UVA (n = 7,152) and Carillion Clinic (n = 6,279). 5 key findings →
Participants: 7,152 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
From 1990 to 2021, global ADOD burden increased markedly in absolute terms. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
10 of the 1,141 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →