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Research

28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.

Find studies

Showing 2,201–2,225 of 3,292 studies · tagged Risk Factors (page 89 of 132) · 28,180 in the whole library · How the 0–100 score works

Download bibliography of the first 500 of these studies, in this order: BibTeX (.bib) · RIS (.ris)

Browse by subject, author or institution

Each number is how many studies that link shows, with your other filters kept.

Subjects

Authors

Names as each record prints them; the same person can appear under two spellings.

Institutions

From OpenAlex; 13,658 studies have no institution on record and are not counted here.

A note on reading research. One study is rarely the final word.

We try to note the size of a study, whether it was in humans or animals, and how early-stage the finding is. If a summary here doesn't make that clear, treat it with extra caution and check the original source.

Endoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol trafficking

✓ Peer-reviewed alzhub usefulness score 45 out of 100. The American journal of pathology 2014-05-09

Disrupted cholesterol homeostasis has been reported in Alzheimer disease and is thought to contribute to disease progression by promoting amyloid β (Aβ) accumulation. 4 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Soluble TREM2 and Alzheimer-related biomarker trajectories in the blood of patients with diabetes based on their cognitive status

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Diabetes research and clinical practice 2022-10-20

We aimed to elucidate the dynamics of blood biomarkers according to the severity of cognitive impairment in patients with type 2 diabetes mellitus (DM) and to identify useful biomarkers for diabetes-related dementia. 4 key findings →

Design: case-control study Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Current Alzheimer research 2007-04-01

Obesity has been related to the incidence of dementia but its impact on cognitive performance in persons without dementia is less clear. 4 key findings →

Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Association of brain amyloidosis with the incidence and frequency of neuropsychiatric symptoms in ADNI: a multisite observational cohort study

✓ Peer-reviewed alzhub usefulness score 45 out of 100. BMJ open 2019-12-18

275 cognitively normal controls (NC), 100 subjective memory complaint (SMC), 559 mild cognitive impairment (MCI) and 143 Alzheimer's disease dementia subjects from the Alzheimer's Disease Neuroimaging Initiative received ( 18 F)-florbetapir positron emission tomography (PET) scans. 4 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of neurochemistry 2008-07-01

Recent findings suggest that hypercholesterolemia may contribute to the onset of Alzheimer's disease-like dementia but the underlying mechanisms remain unknown. 4 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Oxidized cholesterol as the driving force behind the development of Alzheimer's disease

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Frontiers in aging neuroscience 2015-06-19

Alzheimer's disease (AD), the most common neurodegenerative disorder associated with dementia, is typified by the pathological accumulation of amyloid Aβ peptides and neurofibrillary tangles (NFT) within the brain. 4 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Estimates of diagnosed dementia prevalence and incidence among diverse beneficiaries in traditional Medicare and Medicare Advantage

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring 2023-07-01

Approximately half of Medicare beneficiaries are enrolled in Medicare Advantage (MA), a private plan alternative to traditional Medicare (TM). 3 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Chronic Kidney Disease Is a Potential Risk Factor for the Development of Purple Urine Bag Syndrome

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of the American Geriatrics Society 2009-10-01

As they mix together, they become purple.2 According to a few previous reports, PUBS often occurred in elderly women who are bedridden, chronically catheterized, and constipated.3 In addition, PUBS was found in alkaline urine and with higher bacterial counts.3,4 Because of lack of significant patient numbers, the clinical background, underlining diseases, urinanalysis, and incidence of PUBS have not been well documented. 5 key findings →

Design: cohort study Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

General Practice Clinical Data Help Identify Dementia Hotspots: A Novel Geospatial Analysis Approach

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of Alzheimer s Disease 2017-11-10

We have a poor understanding of whether dementia clusters geographically, how this occurs, and how dementia may relate to socio-demographic factors. 5 key findings →

Participants: 14,746 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Neighborhood Disadvantage and Dementia Risk Among Older Patients With Kidney Failure: Differences by Race/Ethnicity and Urbanicity

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Kidney Medicine 2026-07-20

Older patients with kidney failure residing in high-disadvantage neighborhoods, particularly Black patients and those in suburban, rural, or small-town areas, had a higher risk of ADRD compared with those in low-disadvantage neighborhoods. 5 key findings →

Design: cohort study Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Cross-sectional associations of plasma vitamin D with plasma phosphorylated tau-181 and plasma neurofilament light chain in older adults with memory complaints

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurobiology of Disease 2025-07-22

Lack of vitamin D is associated with cognitive decline and Alzheimer's disease. 5 key findings →

Design: cross-sectional Participants: 311 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Searching for responders to multidomain dementia prevention in late life: A pooled analysis of individual participant data from the MAPT and preDIVA trials

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer s & Dementia 2025-01-17

Four hundred eighty-six participants developed dementia during 37,782 person-years of follow-up. 5 key findings →

Participants: 5,205 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Adherence to Mediterranean Diet and Implications for Cardiovascular Risk Prevention

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nutrients 2025-06-12

Significant correlations emerged between higher MEDAS scores and BMI (r = −0.53, p < 0.01), FM% (r = −0.49, p < 0.01), VAT (r = −0.63, p < 0.01), and cIMT (r = −0.88, p < 0.01). 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Associations between Ultrafine Particles and Incident Dementia in Older Adults

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Environmental Science & Technology 2025-03-13

High Resolution Image Download MS PowerPoint Slide Fine particulate matter (PM 2.5 ) is linked to dementia risk, but ultrafine particles (UFPs, <100 nm) may be even more toxic due to their distinct physicochemical properties. 2 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Use of sodium‐glucose cotransporter‐2 inhibitors and risk of dementia: A population‐based cohort study

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Diabetes Obesity and Metabolism 2025-02-10

The final cohort included 47 335 new users of DPP-4i or SGLT-2i. In the primary analysis, the incidence of dementia was 500.2 and 347.5 per 100 000 person-years in users of DPP-4i and SGLT-2i, respectively. 5 key findings →

Participants: 47 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Burden and risk factors of Alzheimer's disease and other dementias in Vietnam from 1990 to 2021 – A comprehensive analysis from global burden disease

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Cerebral Circulation - Cognition and Behavior 2025-01-01

In 2021, the ASRs for AD and other dementias incidence and prevalence in Vietnam were 110.09 (95 % UI: 96.21-126.57) and 649.42 (95 % UI: 556.89-744.39) per 100,000 persons which were comparable to those in the Southeast Asia region and globally, with the burden predominantly observed in individuals aged 65 and older. 5 key findings →

Participants: 100,000 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

The Association of Apathy With Incident Dementia: A Multiple Mediation Analysis of Cardiovascular Risk Factors

✓ Peer-reviewed alzhub usefulness score 45 out of 100. International Journal of Geriatric Psychiatry 2025-05-01

Of the association between apathy and dementia (HR 1.49 [95% CI 0.99-2.41]), 27% was mediated by physical inactivity, BMI and diabetes combined. 5 key findings →

Participants: 3,303 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Community Socioeconomic Disadvantage relates to White Matter Hyperintensity Burden in Mid-to-Late Life Adults

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Biopsychosocial science and medicine 2025-07-17

Residing in communities characterized by socioeconomic disadvantage may confer risk for neurodegenerative brain changes and future neuropathology. 1 key finding →

Participants: 388 Evidence: low

Full summary, score breakdown and related studies → Original source

From across this tag

10 of the 3,281 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

↑ Change the filters

Where “Free full text” comes from

Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read

How the 0–100 score works — and why some entries are capped

This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.

  • Journal tier up to 10 pts
  • Journal's citation record up to 4 pts
  • Study design up to 12 pts
  • Strength of evidence up to 5 pts
  • Peer-review validation up to 10 pts
  • How recent up to 5 pts
  • Sample size up to 4 pts
  • Effect reported up to 3 pts
  • Studied in people up to 3 pts
  • Randomised / blinded up to 2 pts
  • Times cited up to 7 pts
  • Citations per year up to 5 pts
  • Impact for its field and year up to 6 pts
  • Cited by studies here up to 6 pts
  • Still being cited up to 4 pts
  • Senior author's track record up to 4 pts
  • Institution's track record up to 3 pts
  • Multi-centre collaboration up to 3 pts
  • Indexed in PubMed up to 2 pts
  • Free to read up to 2 pts

Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.

Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.

We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.

The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.

See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.

What this library is — and isn't

This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.

1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.

See the full, machine-readable breakdown of this library's coverage →

Newest studies, as a dated timeline →    Atom feed