How much vitamin E is enough? An established use of supplemental vitamin E in humans is in the prevention and therapy of deficiency symptoms. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
28,580 Alzheimer's and dementia studies in plain English, each scored out of 100.
Inflammation plays an important role in health and disease. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
A marked reduction in atherosclerotic lesions was observed. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Prevalence studies suggest that Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) are the most common dementing illnesses in the elderly. 1 key finding →
Design: narrative review Evidence: low
Full summary, score breakdown and related studies → Original source
Down syndrome is a common disorder associated with intellectual disability in humans. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Sleep is implicated in cognitive functioning in young adults. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The prefrontal cortex (PFC) mediates cognitive function that is sensitive to disruption by sleep loss, and molecular mechanisms regulating neural dysfunction induced by chronic sleep restriction (CSR), particularly in the PFC, have yet to be completely understood. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The combination of a sedentary lifestyle and excess energy intake has led to an increased prevalence of obesity which constitutes a major risk factor for several co-morbidities including type 2 diabetes and cardiovascular diseases. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Factors like health concerns, environmental issues, and ethics have driven the rapid rise in veganism's popularity over the last decade. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
A total of eight studies were included from 1,384 search results, reviewing data from 10,449 cognitively unimpaired older adults. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Dietary supplement silver nanoparticles have recently drawn attention following reports of hazards associated with long-term use. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
35/100
Age-related cognitive decline, characterized by memory loss, attention deficits, and reduced executive function, remains a major public health challenge, with limited pharmaceutical interventions offering symptomatic relief. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Five themes emerged. Both older adults and adult children had partial knowledge of dementia and were able to list learning new things and social activities as cognitively stimulating activities. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Dietary intake moderated the association between several cSVD biomarkers and MoCA scores such that the expected negative association between cSVD biomarkers and cognition was seen at low levels of healthy dietary intake, but not at medium or high levels. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Practical implications With 100 percent foreign direct investment permitted in the F&G category in India, the research outcomes will be useful to all food retailers (prospective and current) interested in this retail market. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
34/100
This may be due to caregiving challenges associated with the behavioral symptoms PWD exhibit and their reduced capacities to perform daily tasks. 5 key findings →
Participants: 3,366 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Research participants enrolled in Falls Prevention EBPs reported decreased levels of loneliness and social isolation and were referred by physicians, social workers, and pharmacists using an order in the electronic medical record (EMR). 2 key findings →
Participants: 382 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
CD28 molecule expression on the surface of T cells plays a critical role in upregulation of various cytokines synthesis and T-helper (Th) cell proliferation and differentiation. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Mean activity from actigraphy did not differ within dyad members. 5 key findings →
Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
While both caregivers participated in physical activity, their case studies reveal opportunities to optimize physical activity interventions to support members of the caregiving dyad: (1) targeting mitochondrial fitness—the ability of mitochondria to maintain energy homeostasis with aging—so participants can mitigate the onset of NCDs, fatigue, and overall health outcomes; (2) promoting the self-care and psychological benefits of physical activity such as improved mood and social connectedness; and (3) improving the accurate perceptions of participants’ health and physical activity with specific measurable markers of physical activity. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Univariate analysis revealed that smoking, moderate aerobic exercise and smartphone use were positively correlated with MMSE score. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
34/100
Recent discoveries indicating that the brain retains its ability to adapt and change throughout life have sparked interest in cognitive training (CT) as a possible means to postpone the development of dementia. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
=3.40; P=.04). Greater cognitive improvements were associated with younger age, higher functional status, and lower baseline cognitive function. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Multidomain lifestyle interventions can improve cognitive function and mobile health technologies can deliver cost-effective interventions. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The very long chain polyunsaturated fatty acids (PUFAs) (C18–C22) and n‐3 Omega PUFAs are apparently widely accepted as a part of modern nutrition because of their beneficial effects on metabolism. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
From across this tag
10 of the 1,888 studies in this tag that have a study page, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Cognitive training and cognitive rehabilitation for persons with mild to moderate dementia of the Alzheimer's or vascular type: a review
- Boosting Cognitive Training through Social Engagement: Impacts on Older Adults With Subjective Cognitive Decline
- Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease
- Enhancing memory in late-life depression: the effects of a combined psychoeducation and cognitive training program
- Editorial: Social Determinants of Maintaining Nutrition in Older Adults with Advanced Dementia
- Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases
- Joggin' the Noggin: Towards a Physiological Understanding of Exercise-Induced Cognitive Benefits
- A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children
- Effects of multisite anodal transcranial direct current stimulation combined with cognitive stimulation in patients with Alzheimer's disease and its neurophysiological correlates: A double-blind randomized clinical trial
- Relation of late-life social activity with incident disability among community-dwelling older adults
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,580 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,580 records, built mostly from automated pulls of Europe PMC (62.2% of the library) and OpenAlex (17.8%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.6% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →