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Effects of Chronic REM Sleep Restriction on D 1 Receptor and Related Signal Pathways in Rat Prefrontal Cortex
Yan Han, Xiaosa Wen, Fei Rong, Xinmin Chen, Ruying Ouyang, Shuai Wu, Hua Nian, Wenling Ma. BioMed Research International, 2015
Topic: Gut, metabolism and diet
The prefrontal cortex (PFC) mediates cognitive function that is sensitive to disruption by sleep loss, and molecular mechanisms regulating neural dysfunction induced by chronic sleep restriction (CSR), particularly in the PFC, have yet to be completely understood. The aim of the present study was to investigate the effect of chronic REM sleep restriction (REM-CSR) on the D 1 receptor (D 1 R) and key molecules in D 1 R’ signal pathways in PFC. We employed the modified multiple platform method to create the REM-CSR rat model. The ultrastructure of PFC was observed by electron microscopy. HPLC was performed to measure the DA level in PFC. The expressions of genes and proteins of related molecules were assayed by real-time PCR and Western blot, respectively. The general state and morphology of PFC in rats were changed by CSR, and DA level and the expression of D 1 R in PFC were markedly decreased ( P < 0.01 , P < 0.05 ); the expression of phosphor-PKAc α was significantly lowered in CSR rats ( P < 0.05 ). The present results suggested that the alteration of neuropathology and D 1 R expression in PFC may be associated with CSR induced cognitive dysfunction, and the PKA pathway of D 1 R may play an important role in the impairment of advanced neural function.
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APA 7th
Han, Y., Wen, X., Rong, F., Chen, X., Ouyang, R., Wu, S., et al. (2015). Effects of Chronic REM Sleep Restriction on D 1 Receptor and Related Signal Pathways in Rat Prefrontal Cortex. BioMed Research International. https://doi.org/10.1155/2015/978236
Vancouver
Han Y, Wen X, Rong F, Chen X, Ouyang R, Wu S, et al. Effects of Chronic REM Sleep Restriction on D 1 Receptor and Related Signal Pathways in Rat Prefrontal Cortex. BioMed Research International. 2015. doi:10.1155/2015/978236.
BibTeX
@article{han2015-464f827d,
author = {Han, Yan and Wen, Xiaosa and Rong, Fei and Chen, Xinmin and Ouyang, Ruying and Wu, Shuai and Nian, Hua and Ma, Wenling},
title = {{Effects of Chronic REM Sleep Restriction on D 1 Receptor and Related Signal Pathways in Rat Prefrontal Cortex}},
journal = {BioMed Research International},
year = {2015},
doi = {10.1155/2015/978236},
url = {https://doi.org/10.1155/2015/978236}
}
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Key findings
- The general state and morphology of PFC in rats were changed by CSR, and DA level and the expression of D 1 R in PFC were markedly decreased ( P < 0.01 , P < 0.05 ); the expression of phosphor-PKAc α was significantly lowered in CSR rats ( P < 0.05 ).
- The present results suggested that the alteration of neuropathology and D 1 R expression in PFC may be associated with CSR induced cognitive dysfunction, and the PKA pathway of D 1 R may play an important role in the impairment of advanced neural function.
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Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 20 of the 56 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (BioMed Research International) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “rat”) — scores zero |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 20 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 20 of the 56 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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