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Newest in this topic

  1. Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease 2026-09-14
  2. Cerebral Small Vessel Disease and Risk of Cardiovascular Events and All-Cause Mortality: The Framingham Heart Study 2026-09-07
  3. Regional Distribution of Mineralized Blood Vessels in Alzheimer Disease and Clinicopathological Associations: A Multicenter Autopsy Study 2026-09-01

Studies

903 studies carry this tag.

Date range

1975 to 2026

Top journals

  • Neurology 93
  • Stroke 61
  • Alzheimer s & Dementia 31
  • Brain : a journal of neurology 20
  • Annals of neurology 19

342 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. The lancet. Diabetes & endocrinology 2014-08-24 Risk factors

    Type 2 diabetes is associated with cognitive dysfunction and structural brain changes.

  2. Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2014-08-15 Cognitive tests and assessment

    Delirium is a profound neuropsychiatric disturbance precipitated by acute illness.

  3. Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Molecular psychiatry 2014-08-05 Digital health tools

    Cognitive impairment is highly prevalent among individuals with late-life depression (LLD) and tends to persist even after successful treatment.

  4. Intracranial hypotension: clinical presentation, imaging findings, and imaging-guided therapy

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current opinion in neurology 2014-08-01 Digital health tools

    Recent findings Intracranial hypotension occurs spontaneously, following (lumbar) dural puncture, accidental dural opening, or excessive surgical cerebrospinal fluid drainage.

  5. Regular fish consumption and age-related brain gray matter loss

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. American journal of preventive medicine 2014-07-29 Brain scans and imaging

    Dietary consumption of baked or broiled fish is related to larger gray matter volumes independent of omega-3 fatty acid content.

  6. Reconsidering harbingers of dementia: progression of parietal lobe white matter hyperintensities predicts Alzheimer's disease incidence

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neurobiology of aging 2014-07-21 Vascular contributions

    Accumulating evidence implicates small vessel cerebrovascular disease, visualized as white matter hyperintensities (WMH) on T2-weighted magnetic resonance imaging, in the pathogenesis and diagnosis of Alzheimer's disease (AD).

  7. Multiple or mixed cerebral microbleeds and dementia in patients with vascular risk factors

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurology 2014-07-11 Genetics

    Multiple CMBs or mixed CMBs independently showed higher risk of all-cause dementia.

  8. Diagnostic criteria for vascular cognitive disorders: a VASCOG statement

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer disease and associated disorders 2014-07-01 Getting a diagnosis

    The proposed criteria for VCD provide a coherent approach to the diagnosis of this diverse group of disorders, with a view to stimulating clinical and pathologic validation studies.

  9. Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI?

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Diabetes 2014-06-15 Caregiving

    Diabetes is associated with cognitive dysfunction and an increased risk of dementia.

  10. Vascular risk and Aβ interact to reduce cortical thickness in AD vulnerable brain regions

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Neurology 2014-06-06 Brain scans and imaging

    Aβ and vascular risk interact to enhance cortical thinning in posterior brain regions that are particularly vulnerable to AD.

  11. Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of pharmacovigilance 2014-06-01 Disease mechanisms

    A host of diabetes-related insults to the central nervous system (CNS) have been clearly documented in type-1 and -2 diabetic patients as well as experimental animal models.

  12. Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of neurotrauma 2014-05-08 Inflammation and the immune system

    Traumatic brain injury (TBI) is a significant risk factor for chronic traumatic encephalopathy (CTE), Alzheimer's disease (AD), and Parkinson's disease (PD).

  13. Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Stroke 2014-04-29 Risk genes beyond APOE

    Accumulation of amyloid-β in cerebral blood vessels occurs in familial and sporadic forms of cerebral amyloid angiopathy and is a prominent feature of Alzheimer disease.

  14. Synergistic effects of ischemia and β-amyloid burden on cognitive decline in patients with subcortical vascular mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. JAMA psychiatry 2014-04-01 Brain scans and imaging

    Most patients with svMCI do not exhibit substantial amyloid burden, and CVD does not increase β-amyloid burden as measured by amyloid imaging.

  15. Aberrant brain functional connectivity related to insulin resistance in type 2 diabetes: a resting-state fMRI study

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Diabetes care 2014-03-21 Brain scans and imaging

    Type 2 diabetic patients develop aberrant functional connectivity of the PCC, which is associated with insulin resistance in selected brain regions.

  16. Association of type 2 diabetes with brain atrophy and cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neurology 2014-03-19 Hippocampus size on brain scans

    Midlife onset of diabetes may affect late-life cognition through loss of brain volume.

  17. Incidence of cerebral microbleeds in preclinical Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurology 2014-03-12 Genetics

    This should be considered when designing protocols for amyloid-modifying clinical trials.

  18. Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Neurology 2014-03-12 Vascular contributions

    The small effect of VRFs and LAD on WMH suggests that WMH have a large "nonvascular," nonatheromatous etiology.

  19. Network dysfunction after traumatic brain injury

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature reviews. Neurology 2014-02-11 Brain scans and imaging

    Diffuse axonal injury after traumatic brain injury (TBI) produces neurological impairment by disconnecting brain networks.

  20. Incidence of idiopathic normal pressure hydrocephalus (iNPH): a 10-year follow-up study of a rural community in Japan

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of the neurological sciences 2014-02-03 Disparities

    The estimated incidence of iNPH in a community was higher than those estimated by previous studies where they collected patients at hospitals.

  21. Prevalence of cortical superficial siderosis in a memory clinic population

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Neurology 2014-01-29 Brain scans and imaging

    Agreement for detection of SS was excellent (unweighted κ of 0.81).

  22. Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Frontiers in neurology 2014-01-06 Caregiving

    Cerebral microbleeds (microbleeds) are small, punctuate hypointense lesions seen in T2* Gradient-Recall Echo (GRE) and Susceptibility-Weighted (SWI) Magnetic Resonance Imaging (MRI) sequences, corresponding to areas of hemosiderin breakdown products from prior microscopic hemorrhages.

  23. Hypertension, brain damage and cognitive decline

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Current hypertension reports 2013-12-01 Prevention and risk

    Loss of cognitive function is one the most devastating manifestations of ageing and vascular disease.

  24. Loss of fornix white matter volume as a predictor of cognitive impairment in cognitively normal elderly individuals

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. JAMA neurology 2013-11-01 Hippocampus size on brain scans

    Fornix body volume and axial diffusivity were highly significant predictors (P = .02 and .005, respectively) of cognitive decline from normal cognition.

  25. The microglial sensome revealed by direct RNA sequencing

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Nature Neuroscience 2013-10-27 Inflammation and the immune system

    This study used direct RNA sequencing without amplification or cDNA synthesis to analyze the quantitative transcriptomes of microglia in healthy adult and aged mice.

  26. Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults

    ✓ Peer-reviewed alzhub usefulness score 68 out of 100. Neurology 2013-10-16 Caregiving

    Arterial stiffness was associated with Aβ plaque deposition in the brain, independent of BP and APOE ε4 allele.

  27. Controlled cortical impact results in an extensive loss of dendritic spines that is not mediated by injury-induced amyloid-beta accumulation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurotrauma 2013-10-12 Disease mechanisms

    The clinical manifestations that occur after traumatic brain injury (TBI) include a wide range of cognitive, emotional, and behavioral deficits.

  28. Reliability of two-dimensional and three-dimensional pseudo-continuous arterial spin labeling perfusion MRI in elderly populations: comparison with 15O-water positron emission tomography

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Journal of magnetic resonance imaging : JMRI 2013-09-13 Mild cognitive impairment

    The 3D GRASE pCASL offers better repeatability than 2D EPI pCASL, thereby may provide a reliable imaging marker for the evaluation of disease progression and treatment effects in MCI and early AD subjects.

  29. Multivariate classification of blood oxygen level-dependent FMRI data with diagnostic intention: a clinical perspective

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. AJNR. American journal of neuroradiology 2013-09-12 Digital health tools

    There has been a recent upsurge of reports about applications of pattern-recognition techniques from the field of machine learning to functional MR imaging data as a diagnostic tool for systemic brain disease or psychiatric disorders.

  30. Targeting the neural extracellular matrix in neurological disorders

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience 2013-09-04 Vascular contributions

    The extracellular matrix (ECM) is known to regulate important processes in neuronal cell development, activity and growth.

  31. Neuropsychological assessment and cerebral vascular disease: the new standards

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. Revue neurologique 2013-08-30 Biomarkers

    The adaption of the battery for French-speaking subjects is reported as well as preliminary results of the on-going validation study of the GRECOG-VASC group [Clinical Trial NCT01339195].

  32. Brain atrophy in type 2 diabetes: regional distribution and influence on cognition

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Diabetes care 2013-08-12 Brain scans and imaging

    Neurodegeneration rather than cerebrovascular lesions may play a key role in T2DM-related cognitive impairment.

  33. Neuropathologic basis of white matter hyperintensity accumulation with advanced age

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Neurology 2013-08-09 Brain scans and imaging

    Accumulating white matter changes in advanced age are likely driven by small-vessel ischemic disease.

  34. Relations of arterial stiffness and endothelial function to brain aging in the community

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Neurology 2013-08-09 Brain scans and imaging

    Greater arterial stiffness and pressure pulsatility are associated with brain aging, MRI vascular insults, and memory deficits typically seen in Alzheimer dementia.

  35. The stress response to surgery and postoperative delirium: evidence of hypothalamic-pituitary-adrenal axis hyperresponsiveness and decreased suppression of the GH/IGF-1 Axis

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Journal of geriatric psychiatry and neurology 2013-07-17 Clinical safety

    Hypothalamic-pituitary-adrenal axis hyperresponsiveness and a less frequent suppression of the GH/IGF-1 axis in response to acute stress are possibly involved in delirium pathophysiology.

  36. Going beyond inferior prefrontal involvement in semantic control: evidence for the additional contribution of dorsal angular gyrus and posterior middle temporal cortex

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Journal of cognitive neuroscience 2013-07-16 Vascular contributions

    Semantic cognition requires a combination of semantic representations and executive control processes to direct activation in a task- and time-appropriate fashion [Jefferies, E., & Lambon Ralph, M. A. Semantic impairment in stroke aphasia versus semantic dementia: A case-series comparison.

  37. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. The Lancet Neurology 2013-07-15 Vascular contributions

    An international working group from the Centres of Excellence in Neurodegeneration completed a structured process to develop definitions and imaging standards for markers and consequences of cerebral small vessel disease (SVD).

  38. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Brain : a journal of neurology 2013-07-10 Getting a diagnosis

    Cerebrovascular disease and vascular risk factors are associated with Alzheimer's disease, but the evidence for their association with other neurodegenerative disorders is limited.

  39. Molecular mechanisms of cognitive dysfunction following traumatic brain injury

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Frontiers in aging neuroscience 2013-07-09 Disease mechanisms

    Traumatic brain injury (TBI) results in significant disability due to cognitive deficits particularly in attention, learning and memory, and higher-order executive functions.

  40. Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Acta neuropathologica 2013-07-02 Brain tissue and pathology

    The interstitial fluid (ISF) drainage pathway has been hypothesized to underlie the clearance of solutes and metabolites from the brain.

  41. Primary progressive aphasia and the language network: the 2013 H. Houston Merritt Lecture

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurology 2013-07-01 Digital health tools

    Review of clinical and biological features of primary progressive aphasia (PPA).

  42. Influence of comorbidities in idiopathic normal pressure hydrocephalus - research and clinical care. A report of the ISHCSF task force on comorbidities in INPH

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Fluids and barriers of the CNS 2013-06-10 Vascular contributions

    Idiopathic normal pressure hydrocephalus (INPH) is a syndrome of ventriculomegaly, gait impairment, cognitive decline and incontinence that occurs in an elderly population prone to many types of comorbidities.

  43. Heightened emotional contagion in mild cognitive impairment and Alzheimer's disease is associated with temporal lobe degeneration

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2013-05-28 Mild cognitive impairment

    Emotional changes are common in mild cognitive impairment (MCI) and Alzheimer's disease (AD).

  44. Absence of chronic traumatic encephalopathy in retired football players with multiple concussions and neurological symptomatology

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Frontiers in human neuroscience 2013-05-24 Disease mechanisms

    Our case studies highlight that not all athletes with history of repeated concussions and neurological symptomology present neuropathological changes of CTE.

  45. Enlarged perivascular spaces and cerebral small vessel disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. International journal of stroke : official journal of the International Stroke Society 2013-05-22 Vascular contributions

    Enlarged perivascular spaces are associated with age, lacunar stroke subtype and white matter lesions and should be considered as another magnetic resonance imaging marker of cerebral small vessel disease.

  46. Low cerebral blood flow is associated with lower memory function in metabolic syndrome

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Obesity (Silver Spring, Md.) 2013-05-19 Prevention and risk

    The results underscore the importance of reducing the number of cardiovascular risk factors for maintaining CBF and cognition in an aging population.

  47. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. The Lancet. Neurology 2013-05-01 Caregiving

    The term cerebral small vessel disease (SVD) describes a range of neuroimaging, pathological, and associated clinical features.

  48. Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Sleep 2013-05-01 Vascular contributions

    Study objective Obstructive sleep apnea (OSA) contributes to the development of systemic hypertension, and hypertension strongly predicts the development of white matter change (WMC).

  49. The effects of hypertension on the cerebral circulation

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. American journal of physiology. Heart and circulatory physiology 2013-04-12 How common it is

    Maintenance of brain function depends on a constant blood supply.

  50. Perivascular spaces are associated with atherosclerosis: an insight from the Northern Manhattan Study

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. AJNR. American journal of neuroradiology 2013-04-04 Disparities

    These results suggest that mechanisms leading to atherosclerosis might also lead to an increased number of perivascular spaces.

From across this tag

8 of the 902 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.

All topic tags with their study counts