tau-deposition

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

1. 74/100

   Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer's Disease

   ✓ Peer-reviewed alzhub usefulness score 74 out of 100. Molecular neurodegeneration · 2024-02-17 · Biomarkers

   However, because these biomarkers are strongly associated with the emergence of Aβ pathology, it is difficult to determine the contribution of insoluble tau aggregates to the plasma p-tau signal in blood.

   • Biomarkers
2. 59/100

   White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease

   ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Neurology · 2023-04-17 · Brain scans and imaging

   We found spatially dependent WM degeneration associated with regional flortaucipir SUVRs in Braak stages, suggesting a spatial pattern in WM damage.

   • Brain Scans
3. 48/100

   The association between white matter hyperintensities and amyloid and tau deposition

   ✓ Peer-reviewed alzhub usefulness score 48 out of 100. NeuroImage. Clinical · 2023-03-20 · Brain scans and imaging

   As secondary analyses, we observed effects of age and sex differences, atrophy, cognitive scores, and APOE genotype.

   • Brain Scans
4. 67/100

   Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer's disease

   ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Alzheimer's research & therapy · 2023-02-07 · Brain scans and imaging

   These findings offer novel perspectives to the design of AD clinical trials and aid in understanding the tau accumulation inside and outside MTL in AD.

   • Brain Biology
5. 47/100

   Role of tau deposition in early cognitive decline in Down syndrome

   ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) · 2022-04-01 · Brain scans and imaging

   Similar to late-onset and autosomal dominant Alzheimer's disease (AD), high tau was an indicator of early prodromal AD in DS.

   • Brain Scans
   • Down Syndrome
6. 40/100

   Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease

   ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurobiology of aging · 2021-11-20 · Brain scans and imaging

   Sites of early neuropathologic change provide important clues regarding the initial clinical features of Alzheimer's disease (AD).

   • Brain Biology
7. 47/100

   Sex modifies APOE ε4 dose effect on brain tau deposition in cognitively impaired individuals

   ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain : a journal of neurology · 2021-11-01 · Brain scans and imaging

   Recent studies in cognitively unimpaired elderly individuals suggest that the APOE ε4 allele exerts a dosage-dependent effect on brain tau deposition.

   • Genetics
8. 71/100

   Interactive rather than independent effect of APOE and sex potentiates tau deposition in women

   ✓ Peer-reviewed alzhub usefulness score 71 out of 100. Brain communications · 2021-06-07 · Brain scans and imaging

   The apolipoprotein E gene ( APOE ) is the most important genetic risk factor for sporadic Alzheimer disease, with the ε4 allele being associated with increased cerebral amyloid-β and tau pathologies.

   • Genetics
   • Brain Scans
9. 52/100

   Association of enlarged perivascular spaces with Aβ and tau deposition in cognitively normal older population

   ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Neurobiology of aging · 2020-12-19 · Brain scans and imaging

   The relationship between magnetic resonance imaging (MRI)-visible enlarged perivascular spaces (EPVS) and Aβ and tau deposition is poorly investigated in cognitively normal older population.

   • Brain Scans
   • Early Stage
   • Brain Biology
10. 52/100

    Visual contrast sensitivity is associated with the presence of cerebral amyloid and tau deposition

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Brain communications · 2020-02-26 · Brain scans and imaging

    Visual deficits are common in neurodegenerative diseases including Alzheimer's disease.

    • Brain Scans
    • Early Stage
11. 41/100

    Sex modulates the ApoE ε4 effect on brain tau deposition measured by 18F-AV-1451 PET in individuals with mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Theranostics · 2019-07-09 · Brain scans and imaging

    After applying PVC and controlling for age, education level and global cortical 18 F-AV-45 SUVR, we found that the entorhinal cortex, amygdala, parahippocampal gyrus, posterior cingulate, and occipital ROIs exhibited a significant ApoE ε4 by sex interaction effect (false discovery rate P < 0.1) among MCI individuals.

    • Brain Scans
    • Early Stage
    • Genetics
12. 48/100

    Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) · 2018-03-24 · Brain scans and imaging

    Quantitative assessment of perceived memory functioning may be useful for screening older adults at risk for Alzheimer's disease.

    • Brain Scans

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