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The association between white matter hyperintensities and amyloid and tau deposition
Alban SL, Lynch KM, Ringman JM, Toga AW, Chui HC, Sepehrband F, Choupan J, Alzheimer's Disease Neuroimaging Initiative.. NeuroImage. Clinical, 2023-03-20
Topic: Brain proteins, microglia and lab models
As secondary analyses, we observed effects of age and sex differences, atrophy, cognitive scores, and APOE genotype. WMH volume percent was significantly associated with global β-amyloid (r = 0.28, p < 0.001), but not tau (r = 0.05, p = 0.25). WMH volume percent was higher in individuals with either A + or T + pathology compared to controls, particularly within in the A+/T + group (p = 0.007, Cohen's d = 0.4, t = -2.5). Individual CVRFs nor cumulative CVRF scores were associated with increased WMH volume. These findings highlight potential causes and mechanisms of AD as targets for future preventions and treatments.
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APA 7th
Alban, S. L., Lynch, K. M., Ringman, J. M., Toga, A. W., Chui, H. C., Sepehrband, F., et al. (2023). The association between white matter hyperintensities and amyloid and tau deposition. NeuroImage. Clinical. https://doi.org/10.1016/j.nicl.2023.103383
Vancouver
Alban SL, Lynch KM, Ringman JM, Toga AW, Chui HC, Sepehrband F, et al. The association between white matter hyperintensities and amyloid and tau deposition. NeuroImage. Clinical. 2023. doi:10.1016/j.nicl.2023.103383. PMID: 36965457.
BibTeX
@article{alban2023-36965457,
author = {Alban, S. L. and Lynch, K. M. and Ringman, J. M. and Toga, A. W. and Chui, H. C. and Sepehrband, F. and Choupan, J. and {Alzheimer's Disease Neuroimaging Initiative}},
title = {{The association between white matter hyperintensities and amyloid and tau deposition}},
journal = {NeuroImage. Clinical},
year = {2023},
doi = {10.1016/j.nicl.2023.103383},
pmid = {36965457},
url = {https://doi.org/10.1016/j.nicl.2023.103383}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- As secondary analyses, we observed effects of age and sex differences, atrophy, cognitive scores, and APOE genotype.
- WMH volume percent was significantly associated with global β-amyloid (r = 0.28, p < 0.001), but not tau (r = 0.05, p = 0.25).
- WMH volume percent was higher in individuals with either A + or T + pathology compared to controls, particularly within in the A+/T + group (p = 0.007, Cohen's d = 0.4, t = -2.5).
- Individual CVRFs nor cumulative CVRF scores were associated with increased WMH volume.
- These findings highlight potential causes and mechanisms of AD as targets for future preventions and treatments.
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Study details
- Participants287
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 28 of the 58 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (NeuroImage. Clinical) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 287 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36965457) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 28 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 28 of the 58 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
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