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Home › Research › Topics › r47h

r47h

363 studies tagged r47h, dated 2000-05-01 to 2026-06-02. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies 2026-06-02
  2. The TREM2 agonistic antibody AL002 in early Alzheimer's disease: a phase 2 randomized trial 2026-03-05
  3. Decoding TREM2 Signaling Pathways 2026-01-09

Studies

363 studies carry this tag.

Date range

2000 to 2026

Top journals

  • Molecular neurodegeneration 26
  • Neurobiology of aging 16
  • Neuron 10
  • The Journal of experimental medicine 10
  • Acta neuropathologica 9

147 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. The Lancet. Neurology 2018-07-17 TREM2 and immune genetics

    Alzheimer's disease is a genetically complex disorder; rare variants in the triggering receptor expressed on myeloid cells 2 (TREM2) gene have been shown to as much as triple an individual's risk of developing Alzheimer's disease.

  2. TREM2-Dependent Effects on Microglia in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Frontiers in aging neuroscience 2018-07-09 TREM2 and immune genetics

    Alzheimer's disease (AD) is a late-onset dementia characterized by the deposition of amyloid plaques and formation of neurofibrillary tangles (NFTs) which lead to neuronal loss and cognitive deficits.

  3. The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Science translational medicine 2018-06-20 Tau biomarkers

    Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) levels in the cerebrospinal fluid (CSF) have been associated with Alzheimer disease (AD) status.

  4. The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Molecular neurodegeneration 2018-06-01 TREM2 and immune genetics

    The R47H variant of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) confers greatly increased risk for Alzheimer's disease (AD), reflective of a central role for myeloid cells in neurodegeneration.

  5. TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Inflammation 2018-06-01 TREM2 and immune genetics

    As a recently identified susceptibility gene for Alzheimer's disease (AD), triggering receptor expressed on myeloid cells 2 (TREM2) encodes an immune receptor that is uniquely expressed on microglia, functioning as a modulator of microglial functions including phagocytosis and inflammatory response.

  6. Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The Journal of biological chemistry 2018-05-24 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor expressed on the surface of microglia, macrophages, dendritic cells, and osteoclasts.

  7. TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Cell biology international 2018-05-10 TREM2 and immune genetics

    This study aimed to investigate the effects of triggering receptor expressed on myeloid cell-2 (TREM2) on the production of pro-inflammatory mediators and cytokines induced by lipopolysaccharide (LPS) in BV2 microglia.

  8. The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Immunity 2018-05-08 TREM2 and immune genetics

    The triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial innate immune receptor associated with a lethal form of early, progressive dementia, Nasu-Hakola disease, and with an increased risk of Alzheimer's disease.

  9. TREM2 regulates innate immunity in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neuroinflammation 2018-04-14 TREM2 and immune genetics

    Recent research has shown that the triggering receptor expressed on myeloid cells 2 (TREM2) in microglia is closely related to the pathogenesis of Alzheimer's disease (AD).

  10. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Biochemical and biophysical research communications 2018-04-04 TREM2 and immune genetics

    Neuroinflammation and overactivated microglia underlies the pathogenesis of Parkinson's disease (PD).

  11. Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Stem cell reports 2018-03-29 TREM2 and immune genetics

    The derivation of microglia from human stem cells provides systems for understanding microglial biology and enables functional studies of disease-causing mutations.

  12. TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of biological chemistry 2018-03-29 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is an orphan immune receptor expressed on cells of myeloid lineage such as macrophages and microglia.

  13. Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Molecular neurodegeneration 2018-03-27 TREM2 and immune genetics

    TREM2 is an innate immune receptor specifically expressed in microglia.

  14. Increased expression of TREM2 in peripheral cells from mild cognitive impairment patients who progress into Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. European journal of neurology 2018-03-26 TREM2 and immune genetics

    Neuroinflammation plays a role in the aetiopathogenesis of Alzheimer's disease (AD).

  15. Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Journal of neuroimmunology 2018-03-20 TREM2 and immune genetics

    Alzheimer's disease (AD) has been genetically and pathologically associated with neuroinflammation.

  16. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neuron 2018-03-01 TREM2 and immune genetics

    Variants of TREM2 are associated with Alzheimer's disease (AD).

  17. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neuron 2018-03-01 TREM2 and immune genetics

    Mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to increased Alzheimer's disease (AD) risk.

  18. TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Experimental neurology 2018-02-03 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells-2 (TREM2) was a newly identified receptor expressed on microglia.

  19. Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. International journal of molecular sciences 2018-01-22 TREM2 and immune genetics

    Depending on the species, microglial cells represent 5-20% of glial cells in the adult brain.

  20. Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. The Journal of experimental medicine 2018-01-10 TREM2 and immune genetics

    Alzheimer's disease (AD) is a neurodegenerative disease that causes late-onset dementia.

  21. The rs75932628 and rs2234253 polymorphisms of the TREM2 gene were associated with susceptibility to frontotemporal lobar degeneration in Caucasian populations

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Annals of human genetics 2018-01-10 TREM2 and immune genetics

    Polymorphisms of the triggering receptor expressed on myeloid cells 2 (TREM2) gene have been reported to be potentially associated with the risks of developing frontotemporal lobar degeneration (FTLD), with inconsistent conclusions.

  22. Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Human molecular genetics 2018-01-01 TREM2 and immune genetics

    It is clear that innate immune system status is altered in numerous neurodegenerative diseases.

  23. High TREM2 expression correlates with poor prognosis in gastric cancer

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Human pathology 2017-11-02 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is a member of the immunoglobulin superfamily and associates with TYRO protein tyrosine kinase-binding protein at the cell membrane to form a receptor signaling complex.

  24. TREM2 expression in the human brain: a marker of monocyte recruitment?

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain pathology (Zurich, Switzerland) 2017-10-30 TREM2 and immune genetics

    Mutation in the triggering receptor expressed on myeloid cells (TREM) 2 gene has been identified as a risk factor for several neurodegenerative diseases including Alzheimer's disease (AD).

  25. TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Molecular neurodegeneration 2017-10-16 TREM2 and immune genetics

    Here we report that TREM2 deficiency leads to accelerated and exacerbated hyperphosphorylation and aggregation of tau in a humanized mouse model of tauopathy.

  26. Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain, behavior, and immunity 2017-10-16 TREM2 and immune genetics

    Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse side effect of many antineoplastic agents.

  27. Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Biological psychiatry 2017-10-14 TREM2 and immune genetics

    Recent genetic studies have provided overwhelming evidence of the involvement of microglia-related molecular networks in the pathophysiology of Alzheimer's disease (AD).

  28. TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2017-10-09 TREM2 and immune genetics

    Variants in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) were recently found to increase the risk for developing Alzheimer's disease (AD).

  29. An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. EMBO molecular medicine 2017-10-01 Risk genes beyond APOE

    Sequence variations occurring in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) support an essential function of microglia and innate immunity in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders.

  30. TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. EMBO molecular medicine 2017-10-01 TREM2 and immune genetics

    We have characterised the proteolytic cleavage events responsible for the shedding of triggering receptor expressed on myeloid cells 2 (TREM2) from primary cultures of human macrophages, murine microglia and TREM2-expressing human embryonic kidney (HEK293) cells.

  31. ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Neuroscience letters 2017-09-18 TREM2 and immune genetics

    Triggering receptor expressed in myeloid cells (TREM2) is a member of the immunoglobulin superfamily and is expressed in macrophages, dendritic cells, microglia, and osteoclasts.

  32. TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Scientific reports 2017-09-11 TREM2 and immune genetics

    TREM2 plays a critical role in the alleviation of Alzheimer's disease by promoting Aβ phagocytosis by microglia, but the detailed molecular mechanism underlying TREM2-induced direct phagocytic activity of Aβ remains to be revealed.

  33. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Immunity 2017-09-01 TREM2 and immune genetics

    Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders.

  34. TREM2 in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Molecular neurodegeneration 2017-08-02 TREM2 and immune genetics

    TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other neurodegenerative diseases (NDDs).

  35. TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Cell 2017-08-01 TREM2 and immune genetics

    Elevated risk of developing Alzheimer's disease (AD) is associated with hypomorphic variants of TREM2, a surface receptor required for microglial responses to neurodegeneration, including proliferation, survival, clustering, and phagocytosis.

  36. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 82 out of 100. Nature genetics 2017-07-17 TREM2 and immune genetics

    We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects.

  37. TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Frontiers in aging neuroscience 2017-06-21 TREM2 and immune genetics

    DNAX-activating protein of 12 kDa (DAP12) is a signaling adapter protein expressed in cells that participate in innate immune responses.

  38. Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Acta neuropathologica 2017-06-13 TREM2 and immune genetics

    Conventional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of late onset sporadic Alzheimer's disease (LOAD).

  39. TREM2 protects against cerebral ischemia/reperfusion injury

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Molecular brain 2017-06-07 TREM2 and immune genetics

    Although post-ischemic inflammation induced by the innate immune response is considered an essential step in the progression of cerebral ischemia injury, the role of triggering receptor expressed on myeloid cells 2 (TREM2) in the pathogenesis of ischemic stroke remains to be elucidated.

  40. The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. The EMBO journal 2017-05-30 TREM2 and immune genetics

    Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk for several neurodegenerative diseases including Alzheimer's disease and frontotemporal dementia (FTD).

  41. Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurobiology of disease 2017-05-11 TREM2 and immune genetics

    Traumatic brain injury (TBI) is strongly linked to an increased risk of developing dementia, including chronic traumatic encephalopathy and possibly Alzheimer's disease (AD).

  42. TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. EMBO reports 2017-05-08 Lewy body dementia

    Sequence variations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to an increased risk for neurodegenerative disorders such as Alzheimer's disease and frontotemporal lobar degeneration.

  43. TREM2, Microglia, and Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Trends in molecular medicine 2017-04-22 TREM2 and immune genetics

    Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US.

  44. TREM2-Ligand Interactions in Health and Disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Journal of molecular biology 2017-04-19 TREM2 and immune genetics

    The protein triggering receptor expressed on myeloid cells-2 (TREM2) is an immunomodulatory receptor with a central role in myeloid cell activation and survival.

  45. DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of psychiatric research 2017-04-11 TREM2 and immune genetics

    Recent genome-wide association studies revealed that Triggering receptor expressed on myeloid cells 2 (TREM2) was associated with Alzheimer's disease (AD) and other neurodegenerative diseases.

  46. Elucidating the Role of TREM2 in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neuron 2017-04-01 TREM2 and immune genetics

    Alzheimer's disease (AD) is the sixth leading cause of death in the United States and the most common cause of dementia in the elderly.

  47. The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of neuroinflammation 2017-03-21 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) and apolipoprotein E (APOE) are genetically linked to Alzheimer's disease.

  48. Soluble TREM2 induces inflammatory responses and enhances microglial survival

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. The Journal of experimental medicine 2017-02-16 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed in microglia in the brain.

  49. Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Frontiers in aging neuroscience 2017-01-31 TREM2 and immune genetics

    Heterozygous missense mutations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been reported to significantly increase the risk of developing Alzheimer's disease (AD).

  50. A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Neurobiology of aging 2017-01-20 TREM2 and immune genetics

    Nasu-hakola disease (NHD) is a rare disease characterized by bone cysts and fractures, frontal lobe syndrome, and progressive presenile dementia.

From across this tag

9 of the 363 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts