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TREM2 expression in the human brain: a marker of monocyte recruitment?
Fahrenhold M, Rakic S, Classey J, Brayne C, Ince PG, Nicoll JAR, Boche D, MRC-CFAS.. Brain pathology (Zurich, Switzerland), 2017-10-30
Topic: Brain proteins, microglia and lab models
Mutation in the triggering receptor expressed on myeloid cells (TREM) 2 gene has been identified as a risk factor for several neurodegenerative diseases including Alzheimer's disease (AD). Experimental studies using animal models of AD have highlighted a number of functions associated with TREM2 and its expression by microglial cells. It has therefore been assumed that this is also the case in humans.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Fahrenhold, M., Rakic, S., Classey, J., Brayne, C., Ince, P. G., Nicoll, J. A. R., et al. (2018). TREM2 expression in the human brain: a marker of monocyte recruitment? Brain pathology (Zurich, Switzerland). https://doi.org/10.1111/bpa.12564
Vancouver
Fahrenhold M, Rakic S, Classey J, Brayne C, Ince PG, Nicoll JAR, et al. TREM2 expression in the human brain: a marker of monocyte recruitment? Brain pathology (Zurich, Switzerland). 2018. doi:10.1111/bpa.12564. PMID: 28987033.
BibTeX
@article{fahrenhold2018-28987033,
author = {Fahrenhold, M. and Rakic, S. and Classey, J. and Brayne, C. and Ince, P. G. and Nicoll, J. A. R. and Boche, D. and MRC-CFAS},
title = {{TREM2 expression in the human brain: a marker of monocyte recruitment?}},
journal = {Brain pathology (Zurich, Switzerland)},
year = {2018},
doi = {10.1111/bpa.12564},
pmid = {28987033},
url = {https://doi.org/10.1111/bpa.12564}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Experimental studies using animal models of AD have highlighted a number of functions associated with TREM2 and its expression by microglial cells.
- It has therefore been assumed that this is also the case in humans.
- However, there is very limited information concerning the cellular expression of TREM2 in the human brain.
- As part of investigations of microglia using post-mortem resources provided by the Medical Research Council Cognitive Function and Ageing Studies (MRC-CFAS), we immunostained the cerebral cortex of 299 participants for TREM2 using the Sigma antibody HPA010917 and compared with the macrophage/microglial markers Iba1 and CD68.
Why it matters
This study examined where TREM2 is expressed in human brain tissue and questioned the assumption that findings from animal models apply directly to humans. It is descriptive human tissue research and does not test a treatment.
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Study details
- Participants299
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 46 of the 96 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain pathology (Zurich, Switzerland)) |
| Journal's citation record | 2 / 4 | Brain Pathology: journal h-index 183 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 299 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 76 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.6 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 2 / 6 | Cited 2.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 9 other studies in this library |
| Still being cited | 1 / 4 | Cited 12 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 2 / 3 | University of Cambridge: institution h-index 1,973 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28987033) |
| Free to read | 2 / 2 | Free to read |
| Points | 46 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 46 of the 96 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
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